Results 101 to 110 of about 235,257 (355)

ANTI-INFLAMMATORY AND ANTI-ALLERGIC FEATURES OF ANTIBODIES TO HISTAMINE IN RELEASE-ACTIVE FORM: REVIEW OF EXPERIMENTAL AND CLINICAL RESEARCHES

Детские инфекции (Москва), 2015
Preclinical and clinical studies of medical preparations (rengalin, ergoferon) containing release-active (P-A) antibodies to histamine confirmed their ability to provide anti-inflammatory and anti-allergic effect.
E. S. Zhavbert, Yu. L. Dugina, O. I. Epshtein   +2 more
doaj   +1 more source

Validation of the European Society of Cardiology Ischemic and Bleeding Risk Criteria for Risk Stratification After Endovascular Therapy in Japanese Patients With Lower Extremity Artery Disease

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background The European Society of Cardiology (ESC) guidelines for peripheral artery disease recommend antithrombotic strategies based on high ischemic risk (HIR) and high bleeding risk (HBR) criteria. However, their prognostic value in patients with lower extremity artery disease (LEAD) undergoing endovascular therapy (EVT) remains unclear ...
Hirokazu Shimono, Daisuke Kanda, Akihiro Tokushige, Nobuhiro Ito, Yutaro Nomoto, Hiroyuki Tabata, Kenta Ohmure, Takuro Kubozono, Mitsuru Ohishi   +8 more
wiley   +1 more source

Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation

Journal of Neuroinflammation, 2016
BackgroundHistamine is an amine widely known as a peripheral inflammatory mediator and as a neurotransmitter in the central nervous system. Recently, it has been suggested that histamine acts as an innate modulator of microglial activity.
S. M. Rocha, Tatiana Saraiva, A. Cristóvão, R. Ferreira, T. Santos, Marta Esteves, Cláudia Saraiva, Goun Je, L. Cortes, J. Valero, G. Alves, A. Klibanov, Yoon-Seong Kim, L. Bernardino   +13 more
semanticscholar   +1 more source

Effects of Trimethoprim on Three Previously Proposed Putative Biomarkers for OCT2/MATE‐Mediated Renal Drug‐Drug Interactions in Healthy Volunteers

Clinical Pharmacology &Therapeutics, EarlyView.
Regulatory agencies request the assessment of the potential of new drugs to cause transporter‐mediated drug‐drug interactions (DDI). This assessment can be improved by integrating endogenous biomarkers during drug development. Regarding the renal excretion of drugs such as metformin, the organic cation transporter (OCT) 2 and multidrug and toxin ...
Jana Picurová, Fabian Müller, Daniel Auge, Jörg König, Martin F. Fromm, Arne Gessner   +5 more
wiley   +1 more source

Structure of the human histamine H1 receptor complex with doxepin

Nature, 2011
The biogenic amine histamine is an important pharmacological mediator involved in pathophysiological processes such as allergies and inflammations. Histamine H1 receptor (H1R) antagonists are very effective drugs alleviating the symptoms of allergic ...
T. Shimamura, M. Shiroishi, S. Weyand, Hirokazu Tsujimoto, G. Winter, V. Katritch, R. Abagyan, V. Cherezov, Wei Liu, G. Han, Takuya Kobayashi, R. Stevens, S. Iwata   +12 more
semanticscholar   +1 more source

Associations Between Microbial Depletion and Autonomic Dysregulation in Binge‐Eating Disorder

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective The interplay between the gut microbiome and autonomic nervous system remains unexplored in binge‐eating disorder (BED). We aimed to explore specific microbial alterations in BED and examine their potential association with cardiac vagal tone as a distinct bio‐behavioral phenotype.
Shuang Liang, Esben Strodl, Leanne Barron, Matthew Bambling, Luis Vitetta   +4 more
wiley   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, EarlyView.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Symptoms of pseudoallergy and histamine metabolism disorders [PDF]

, 2016
Histamine intolerance is a poorly investigated type of hypersensitivity responsible for a number of often serious symptoms, erroneously interpreted as food allergy.
Agata Wawrzyniak, Wawrzyniak, Agata, Kacik, Joanna, Kalicki, Bolesław, Joanna Kacik, Bolesław Kalicki, Magda Rakowska, Rakowska, Magda   +7 more
core   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock

Nature Communications, 2015
Histamine-induced vascular leakage is an integral component of many highly prevalent human diseases, including allergies, asthma and anaphylaxis. Yet, how histamine induces the disruption of the endothelial barrier is not well defined.
Constantinos M Mikelis, M. Simaan, Koji Ando, S. Fukuhara, A. Sakurai, Panomwat Amornphimoltham, Andrius Masedunskas, R. Weigert, T. Chavakis, R. Adams, S. Offermanns, N. Mochizuki, Yi Zheng, J. Gutkind   +13 more
semanticscholar   +1 more source