Results 71 to 80 of about 235,257 (355)

Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

open access: yesAdvanced Science, EarlyView.
NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao   +8 more
wiley   +1 more source

Mucoadhesive Peptide‐Catalase Self‐Assembled Nano‐Formulation for Effective Treatment of Mucosal Inflammatory Diseases

open access: yesAdvanced Science, EarlyView.
CR8L10 is self‐assembled with catalase (CAT) to form CR8L10@CAT nanocomplexes, which can anchor to mucosal surfaces via thiol‐disulfide exchange with mucin, thereby enhancing their mucosal retention. The efficient reactive oxygen species (ROS) scavenging at inflamed sites would then result in successful treatment in both the intravesical IC/BPS model ...
Xinzhu Li   +13 more
wiley   +1 more source

好塩基球からのヒスタミン遊離に関する研究. 1 自動分析装置による全血からのヒスタミン遊離の測定 [PDF]

open access: yes, 1983
Histamine released from whole blood was determined by an automated fiuorometric histamine analysis system. The increased release of histamine from basophils by anti-IgE was observed in ten healthy subjects and 12 extrinsic asthma patients, while the ...
Tanizaki, Yoshiro   +9 more
core   +1 more source

Histamine Induces Bovine Rumen Epithelial Cell Inflammatory Response via NF-κB Pathway

open access: yesCellular Physiology and Biochemistry, 2017
Background/Aims: Subacute ruminal acidosis (SARA) is a common disease in high-producing lactating cows. Rumenitis is the initial insult of SARA and is associated with the high concentrations of histamine produced in the rumen of dairy cows during SARA ...
Xudong Sun   +8 more
semanticscholar   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

open access: yesAdvanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori   +10 more
wiley   +1 more source

Study of Histamine Detection using Liquid Chromatography and Gas Chromatography [PDF]

open access: yes, 2021
Histamine is a heterocyclic amine shaped by decarboxylation of the histidine. It is a compound that lack chromophore and involatile. However, the detection of histamine is imperative due to the characteristic of histamine has given several disadvantages ...
Muhammad Mukram, Mohamed Mackeen   +3 more
core   +1 more source

HISTAMIN EVALUATION ON FROZEN TUNA LOINS (THUNNUS SP.) AS AN EXPORT REQUIREMENT STANDARD IN DENPASAR LABORATORY, BALI, INDONESIA

open access: yesRussian Journal of Agricultural and Socio-Economic Sciences, 2021
Tuna is one of the essential export commodities in Indonesia. Histamine in this species can cause a food safety hazard. Therefore, a maximum standard of histamine content must be applied to frozen loin tuna products to reduce food safety risks.
Budiadnyani I G.A.   +4 more
doaj   +1 more source

A Supramolecular Thermal Switch for Precision Pyroptosis via Host−Guest Recognition and Electrostatic Interactions

open access: yesAdvanced Science, EarlyView.
A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu   +8 more
wiley   +1 more source

Identification of Histidine Decarboxylase Expression using a Histamine Antibody Staining Technique [PDF]

open access: yes, 2004
Cells containing histamine were identified in a third instar brain of a normal Drosophila melanogaster larva using a whole-mount staining technique that detects histamine.
Kroodsma, Derrick
core   +1 more source

Exogenous Histamine Stimulates Colorectal Cancer Implant Growth via Immunosuppression in Mice

open access: yesJournal of Pharmacological Sciences, 2005
Results from a limited number of studies suggest a potential role for endogenous histamine in regulating tumor growth in immunocompetent cells. The present study examined the effects of exogenous histamine on colorectal cancer growth and the immune ...
Kazuyoshi Tomita, Susumu Okabe
doaj   +1 more source

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