Histamine H1 antagonists and clinical characteristics of febrile seizures [PDF]
International Journal of General Medicine, 2012 Mohammed A ZolalyDepartment of Pediatrics, College of Medicine, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi ArabiaBackground: The purpose of this study was to determine whether seizure susceptibility due to antihistamines is provoked in ...
Zolaly MA
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The Impact of H1–H4 Receptor Antagonists on the Levels of Selected Oxidative Stress Markers in Liver and Muscle Tissue in an Animal Model of Colitis [PDF]
PharmaceuticalsBackground/Objectives: The global prevalence and incidence of inflammatory bowel diseases have risen in the past two decades. Among them, Crohn’s disease and ulcerative colitis are still challenging to treat due to vascular and proliferative alterations.
Bartosz Bogielski +16 more
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Screening and identification of the H1R antagonists from natural products by BODIPY FL histamine recognition and DPHD-anchored bombardment coupled with target cell extraction [PDF]
Frontiers in PharmacologyIntroductionHistamine is an important mediator of allergy, and inhibiting its binding to H1 receptors (H1R) is a key method to alleviate allergic diseases.
Xinqi Li +5 more
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Delineating the role of histamine-1- and -4-receptors in a mouse model of Th2-dependent antigen-specific skin inflammation. [PDF]
PLoS ONE, 2014 BACKGROUND: Histamine drives pruritus in allergic skin diseases which clinically constitutes a most disruptive symptom. Skin pathology in allergic skin diseases is crucially influenced by different T-helper subsets. However, the contribution of different
Subhashree Mahapatra +10 more
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Improved survival in several cancers with use of H1-antihistamines desloratadine and loratadine
Translational Oncology, 2021 Background: We have previously shown an association with substantially improved survival in breast cancer and melanoma for desloratadine and loratadine users, and set out to find whether an improved survival can be seen in tumors with and without a known
Ildikó Fritz +2 more
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Suppression of wheal and flare in histamine test by the main H1 antihistamines commercialized in Brazil [PDF]
Anais Brasileiros de Dermatologia, 2018 : Background: Several dermatoses are mediated by histamine, such as urticaria, angioedema, and papular urticaria. There are no Brazilian studies comparing the potency of antihistamines.
Helena Maciel-Guerra +6 more
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Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells
Scientific Reports, 2021 Cancer therapy is often hampered by the disease’s development of resistance to anticancer drugs. We previously showed that the autonomously upregulated product of fibroblast growth factor 13 gene (FGF13; also known as FGF homologous factor 2 (FHF2)) is ...
Nobuki Matsumoto +5 more
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The Roles of Cardiovascular H2-Histamine Receptors Under Normal and Pathophysiological Conditions
Frontiers in Pharmacology, 2021 This review addresses pharmacological, structural and functional relationships among H2-histamine receptors and H1-histamine receptors in the mammalian heart.
Joachim Neumann +4 more
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Antihistaminergics and inverse agonism. Potential therapeutic applications [PDF]
, 2013 The accurate characterization of the molecular mechanisms involved in the action of receptor ligands is important for their appropriate therapeutic use and safety.
Davio, Carlos Alberto +4 more
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Journal of Pharmacological Sciences, 2008 We evaluated changes in the binding properties of sedative and non-sedative histamine H1–receptor antagonists induced by internalization of H1 receptors in intact human U373 MG astrocytoma cells.
Shigeru Hishinuma +4 more
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