Results 31 to 40 of about 35,308 (311)
Antihistaminergics and inverse agonism. Potential therapeutic applications [PDF]
, 2013 The accurate characterization of the molecular mechanisms involved in the action of receptor ligands is important for their appropriate therapeutic use and safety.
Davio, Carlos Alberto +4 more
core +8 more sources
Influence of mirtazapine on salivary cortisol in depressed patients [PDF]
, 2003 Unlike other antidepressants, mirtazapine does not inhibit the reuptake of norepinephrine or serotonin but acts as an antagonist at presynaptic alpha(2)-receptors, at postsynaptic 5-HT2 and 5-HT3 receptors, and at histaminergic H1 receptors. Furthermore,
Baghai, Thomas C. +3 more
core +1 more source
Histamine and Delirium: Current Opinion
Frontiers in Pharmacology, 2019 Delirium is a very common, but refractory clinical state, notably present in intensive care and in the growing aging community. It is characterized by fluctuating disturbances in a number of key behavioral features, namely cognition, mood, attention ...
Paul L. Chazot +3 more
doaj +1 more source
Histamine stimulates the proliferation of small and large cholangiocytes by activation of both IP3/Ca2+ and cAMP-dependent signaling mechanisms [PDF]
, 2012 Although large cholangiocytes exert their functions by activation of cyclic adenosine 3',5'-monophosphate (cAMP), Ca(2+)-dependent signaling regulates the function of small cholangiocytes. Histamine interacts with four receptors, H1-H4HRs.
Fanyin Meng +15 more
core +1 more source
Percolation on interacting, antagonistic networks [PDF]
J. Stat. Mech. (2013) P05005, 2012 Recently, new results on percolation of interdependent networks have shown that the percolation transition can be first order. In this paper we show that, when considering antagonistic interactions between interacting networks, the percolation process might present a bistability of the equilibrium solution.
arxiv +1 more source
Improved survival in several cancers with use of H1-antihistamines desloratadine and loratadine
Translational Oncology, 2021 Background: We have previously shown an association with substantially improved survival in breast cancer and melanoma for desloratadine and loratadine users, and set out to find whether an improved survival can be seen in tumors with and without a known
Ildikó Fritz +2 more
doaj
Percolation on interdependent networks with a fraction of antagonistic interactions [PDF]
Journal of Statistical Physics, 152,1069 (2013), 2013 Recently, the percolation transition has been characterized on interacting networks both in presence of interdependent and antagonistic interactions. Here we characterize the phase diagram of the percolation transition in two Poisson interdependent networks with a percentage q of antagonistic nodes. We show that this system can present a bistability of
arxiv +1 more source
Effects of H1–receptor antagonists in antidepressant tests in rats [PDF]
Al Ameen Journal of Medical Sciences, 2008 : Considering the vast data suggesting the role of brain histamine(HA) in behaviour,emotions,anxiety and depression;four H1-receptor antagonists; promethazine, diphenhydramine, cyclizine and pheniramine were subjected to antidepressant tests in rats ...
Chitra C.Khanwelkar
doaj
Frontiers in Immunology, 2022 BackgroundSystemic allergic reaction is characterized by vasodilation and vascular leakage, which causes a rapid, precipitous and sustained decrease in arterial blood pressure with a concomitant decrease of cardiac output.
Shangze Gao +9 more
doaj +1 more source
Pepducins as a potential treatment strategy for asthma and COPD. [PDF]
, 2018 Current therapies to treat asthma and other airway diseases primarily include anti-inflammatory agents and bronchodilators. Anti-inflammatory agents target trafficking and resident immunocytes and structural cells, while bronchodilators act to prevent or
Benovic, Jeffrey L. +4 more
core +2 more sources