Results 61 to 70 of about 7,687 (206)
Frontiers in Pharmacology, 2020 Many behavioral and psychological symptoms of dementia (BPSD) share similarities in executive functioning and communication deficits with those described in several neuropsychiatric disorders, including Alzheimer’s disease (AD), epilepsy, schizophrenia ...
Nermin Eissa +5 more
doaj +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.Pitolisant, an FDA‐approved H3R antagonist, counteracts the rewarding and sedative effects of ethanol, reduces alcohol intake, and alleviates the negative affect during withdrawal. This might occur via the antagonism of presynaptic autoreceptors and heteroreceptors H3Rs in the lateral habenula, thereby activating the H2R/p‐CREB/BDNF signaling and ...
Yan Zhao +13 more
wiley +1 more source
Natural Sciences, Volume 6, Issue 1, January 2026.Magnetic mg‐Fe3O4‐APTES nanoparticle‐doped p(HEMA)‐phenylboronic acid cryogel membranes are developed for the efficient removal of dopamine from pharmaceutical wastewater. Utilizing boronate affinity interactions, the system demonstrates a high adsorption capacity of 1969.1 mg/g and eliminates 81.3% of the target molecule within 15 minutes.
Cansu İlke Kuru‐Sumer +2 more
wiley +1 more source
Histamine and migraine revisited: mechanisms and possible drug targets
The Journal of Headache and Pain, 2019 Objective To review the existing literature on histamine and migraine with a focus on the molecule, its receptors, its use in inducing migraine, and antihistamines in the treatment of migraine. Background Histamine has been known to cause a vascular type
Jacob Worm +2 more
doaj +1 more source
Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry
ChemistryOpen, Volume 15, Issue 1, January 2026.Piperazine‐based bioactive molecules represent a versatile class of compounds with broad therapeutic potential. Structural modification of the piperazine scaffold governs key structure–activity relationships, enabling antibacterial, antifungal, antitumor, neuroactive, and anti‐inflammatory activities.
Assel Ten +5 more
wiley +1 more source
Allergology International, 2014 Histamine plays important roles in inflammation and nervous irritability in allergic disorders, including atopic dermatitis (AD). It has been shown to regulate the expression of pruritic factors, such as nerve growth factor and semaphorin 3A, in skin ...
Yusuke Ohsawa, Noriyasu Hirasawa
doaj +1 more source
Frontiers in Pharmacology, 2020 The involvement of spinal release of histamine in the nociceptive behaviors induced by cholecystokinin-8 (CCK-8) was investigated in mice. Intrathecal (i.t.) injection of CCK-8 elicited the nociceptive behaviors consisting of biting and licking.
Takafumi Hayashi +7 more
doaj +1 more source
Journal of Translational Medicine, 2007 Background Medical implants often fail as a result of so-called foreign body reactions during which inflammatory cells are recruited to implant surfaces.
Eaton John W +2 more
doaj +1 more source
Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 1, January/March 2026.Abstract INTRODUCTION Repurposing Food and Drug Administration (FDA)‐approved drugs could accelerate treatment development for Alzheimer's disease (AD). METHODS Using the MarketScan claims database (2011 to 2020), we applied a trial emulation approach in two base cohorts: (1) individuals with mild cognitive impairment (MCI cohort) and (2) individuals ...
Reina Tonegawa‐Kuji +10 more
wiley +1 more source
Histamine H1 receptor antagonists enhance the efficacy of antibacterials against Escherichia coli
BMC Veterinary Research, 2019 Background H1 receptor antagonists are commonly used for the treatment of allergic diseases. The aim of this study was to find out, if antihistaminic compounds like mepyramine have the ability to influence the activity of antibacterials.
G. G. Bruer +7 more
doaj +1 more source