Results 81 to 90 of about 13,549 (209)

Effects of administration of histamine and its H1, H2, and H3 receptor antagonists into the primary somatosensory cortex on inflammatory pain in rats [PDF]

Iranian Journal of Basic Medical Sciences, 2014
Objective(s): The present study investigated the effects of microinjection of histamine and histamine H1, H2, and H3 receptor antagonists, chlorpheniramine, ranitidine and thioperamide, respectively into the primary somatosensory cortex (PSC) on ...
Esmaeal Tamaddonfard, Nasrin Hamzeh Gooshchi   +1 more
doaj  

Fluoxetine: a case history of its discovery and preclinical development [PDF]

, 2014
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N, Bergstrom RF, Bravo L, Bremner JD, Burrows GD, Chouinard G, Datla KP, Esther Berrocoso, Juan Antonio Mico, Kreiss DS, Laura Perez-Caballero, Lemberger L, Li Q, Lidia Bravo, Maj J, Nibuya M, Owens MJ, Rutter JJ, Sonia Torres-Sanchez, Stevens JC, Wong DT   +20 more
core   +2 more sources

Chemical Genetic Identification of the Histamine H1 Receptor as a Stimulator of Insulin-Induced Adipogenesis [PDF]

, 2004
A large collection of bioactive compounds with diverse biological effects can be used as probes to elucidate new biological mechanisms that influence a particular cellular process.
Yoshinori Kawazoe, Satoshi Tanaka, Motonari Uesugi, Green, Green, Rosen, MacDougald, Zhang, Dowell, Font de Mora, Engelman, Ho, Ohtsu, Hill, Hill, Nakamura, Hiroi, Elbashir, Brummelkamp, Beaven, Beaven, White, Barocelli, Schwartz, Simons, Huang, Masaki, Morimoto, Fulop, Laurier, Ishikawa, Choi, Schreiber, Stockwell, Peterson, Crews, Root, Schreiber, Kuruvilla, Ohmori, Shore   +40 more
core   +3 more sources

Molecular Determinants Responsible for Sedative and Non-sedative Properties of Histamine H1–Receptor Antagonists

Journal of Pharmacological Sciences, 2014
There is argument whether non-sedative properties of histamine H1–receptor antagonists (antihistamines) are determined by their active extrusions from the brain via P-glycoprotein or their restricted penetration through the blood-brain barrier.
Yoshihiro Uesawa, Shigeru Hishinuma, Masaru Shoji   +2 more
doaj   +1 more source

Histamine H4 receptor regulates IL-6 and INF-γ secretion in native monocytes from healthy subjects and patients with allergic rhinitis

Clinical and Translational Allergy, 2019
Histamine H1 receptor (H1R) and histamine H4 receptor (H4R) are essential in allergic inflammation. The roles of H4R have been characterized in T cell subsets, whereas the functional properties of H4R in monocytes remain unclear.
Hua Peng, Jian Wang, Xiao Yan Ye, Jie Cheng, Cheng Zhi Huang, Li Yue Li, Tian Ying Li, Chun Wei Li   +7 more
doaj   +1 more source

Protective effects of exogenous and endogenous hydrogen sulfide in mast cell-mediated pruritus and cutaneous acute inflammation in mice. [PDF]

, 2016
Published onlineJournal ArticleThis is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.The recently described 'gasomediator' hydrogen sulfide (H2S) has been involved in pain mechanisms, but its ...
Cerqueira, AR, Costa, SK, De Nucci, G, Ekundi-Valentim, E, Florenzano, J, Muscará, MN, Ribela, MT, Rodrigues, L, Santos, KT, Schmidt, TP, Soares, AG, Teixeira, SA, Whiteman, M, Wood, M   +13 more
core   +1 more source

Evaluation of the Histamine H1-Antagonist-Induced Place Preference in Rats

Japanese Journal of Pharmacology, 1999
The place preferences by some histamine H1 antagonists, such as tripelennamine, optical isomers of chlorpheniramine (dl-, d- and l-forms) and pyrilamine, in rats were evaluated with the conditioned place preference paradigm. In the present study, tripelennamine and all of the optical isomers of chlorpheniramine, but not pyrilamine, produced a ...
T, Suzuki, T, Mori, M, Tsuji, M, Nomura, M, Misawa, K, Onodera   +5 more
openaire   +2 more sources

Activation of Microglia by Histamine and Substance P

Cellular Physiology and Biochemistry, 2014
Background: Activated microglia perform many of the immune effector functions typically associated with macrophages. However, the regulators involved in microglial activation are not well defined.
Jin Zhu, Chen Qu, Xiang Lu, Shu Zhang
doaj   +1 more source

Randomized placebo-controlled trial comparing desloratadine and montelukast in monotherapy and desloratadine plus montelukast in combined therapy for chronic idiopathic urticaria [PDF]

, 2004
BACKGROUND: H 1 -receptor antagonists are considered to be particularly effective in reducing pruritus, and they are therefore recommended as first-line treatment in patients with chronic idiopathic urticaria (CIU).
DI LORENZO, G., Ditta, V., ESPOSITO PELLITTERI, M., LO BIANCO, C., Mansueto, P., Martinelli, N., Pacor, M., Rini, G.   +7 more
core   +1 more source

Cutaneous manifestations due to histamine H1 antagonist [PDF]

World Allergy Organization Journal, 2020
Flore Kurihara, Tullia De Risi Pugliese, Emmanuelle Amsler, Jean Eric Autegarden, Olivier Bayrou, Hafida Gaouar, catherine Pecquet, Annick Barbaud, Angele Soria   +8 more
openaire   +2 more sources