Results 81 to 90 of about 28,670 (268)
Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry
ChemistryOpen, Volume 15, Issue 1, January 2026.Piperazine‐based bioactive molecules represent a versatile class of compounds with broad therapeutic potential. Structural modification of the piperazine scaffold governs key structure–activity relationships, enabling antibacterial, antifungal, antitumor, neuroactive, and anti‐inflammatory activities.
Assel Ten +5 more
wiley +1 more source
The Effects of Histaminergic Agents in the Nucleus ccumbens of Rats in the Elevated Plus-Maze Test of Anxiety [PDF]
Iranian Journal of Psychiatry, 2010 "n Objective: "n The nucleus accumbens (NAc) receive histaminergic neurons from tuberomammillary nuclei. There are reports indicating that central histamine systems are involved in many physiological behavioral processes, including anxiety.
Ameneh Rezayof +2 more
doaj
Predictors of Response to Oral Medications and Low-Histamine Diet in Patients with Chronic Urticaria
Journal of Immunology Research, 2022 Background. Chronic urticaria (CU) is comprised of diverse phenotypes, and thus, a shift towards a precision medical approach is warranted in its management. Methods. This study enrolled 78 patients with CU.
Hui-Ling Chiang +4 more
doaj +1 more source
A Mechanism‐Based Multi‐Level Population PK/PD Model for Potassium‐Competitive Acid Blockers
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.Schematic overview of a mechanism‐based, multi‐level population model for potassium‐competitive acid blockers. ABSTRACT Potassium‐competitive acid blockers (PCABs) are emerging alternatives to proton pump inhibitors for the treatment of acid‐related diseases.
Woojin Jung +6 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 316-323, January 2026.Abstract Aims While discontinuation of glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) before esophagogastroduodenoscopy (EGD) is not universally mandated, safety concerns persist. Evidence remains insufficient for managing specific patient subgroups, particularly in Asian populations. We aimed to provide evidence for stratified risk assessment in
Hiroyuki Hisada +13 more
wiley +1 more source
Львівський клінічний вісник, 2019 Introduction. Antisecretory drugs are commonly used in the complex treatment of most diseases of the upper gastrointestinal tract. Today, proton pomp inhibitors (PPI) have a priority in the basic treatment for acid-dependent diseases of the ...
Pliatsko M.
doaj +1 more source
Histamine and migraine revisited: mechanisms and possible drug targets
The Journal of Headache and Pain, 2019 Objective To review the existing literature on histamine and migraine with a focus on the molecule, its receptors, its use in inducing migraine, and antihistamines in the treatment of migraine. Background Histamine has been known to cause a vascular type
Jacob Worm +2 more
doaj +1 more source
, 1988 Updates on research conducted by the Boston University School of ...
Boston University School of Medicine
core
Analgesic effect of hystamine H2 receptor antagonists in formalin-induced pain model in rats [PDF]
, 2011 JUSTIFICATIVA E OBJETIVOS: Antagonistas de receptor de histamina apresentam efeitos sobre a dor. Antagonistas de receptor H1 apresentam efeito analgésico local, o papel de antagonistas de receptor H2 sobre a dor no sistema nervoso periférico ainda não ...
ASHMAWI, Hazem Adel +3 more
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Expanding the Immunologic and Neuronal Landscape of IgE‐Mediated Anaphylaxis
Immunological Reviews, Volume 337, Issue 1, January 2026.ABSTRACT Anaphylaxis is a life‐threatening immunoglobulin E (IgE)‐mediated type I hypersensitivity reaction with rising prevalence and burden. It involves mast cell degranulation upon cross‐linking of antigen on mast cell‐bound IgE. Mechanisms of IgE‐mediated anaphylaxis remain incompletely understood, particularly the induction of systemic symptoms ...
Ruchi Biswas +2 more
wiley +1 more source