Results 131 to 140 of about 291,783 (305)
Advanced Science, EarlyView.A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa +8 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2015 The success of siRNA-based therapeutics highly depends on a safe and efficient delivery of siRNA into the cytosol. In this study, we post-modified the primary amines on dendritic polyglycerolamine (dPG-NH2) with different ratios of two relevant amino ...
Fatemeh Sheikhi Mehrabadi +5 more
doaj +1 more source
Histidine and carnosine alleviated hepatic steatosis in mice consumed high saturated fat diet. European Journal of Pharmacology [PDF]
, 2012 [[abstract]]The effects of histidine, alanine and carnosine on activity and/or mRNA expression of lipogenic enzymes and sterol regulatory element-binding proteins (SREBPs) in liver and adipose tissue from high fat diet treated mice were examined ...
蒙美津;Mong, Mei-Chin;趙哲毅;Chao, Che-Yi;殷梅津;YIN, MEI-CHIN*
core
Advanced Science, EarlyView.Engineered phage‐based trifunctional nanofibers are developed for synergistic biofilm eradication. Biofilm‐binding phages, armed with AuNPs and TCPP, serve as both warheads and scaffolds, endowing the phototherapy agents with biofilm‐anchoring ability. Upon light irradiation, AuNPs induce photothermal therapy, while TCPP generates 1O2 for photodynamic ...
Ying Cao +9 more
wiley +1 more source
Synthesis of a HDC-GFP Promoter-Gene Fusion as a Tool to Identify Histaminergic Cells and Examine HDC Regulation [PDF]
, 2007 The promoter region for the Histidine decarboxylase gene (pHdc), which is required for synthesis of the neurotransmitter histamine, has been functionally identified in Drosophila melanogaster.
Anderson, Erik R
core +1 more source
Harnessing Phase Separation for the Development of High‐Performance Hydrogels
Advanced Science, EarlyView.ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao +3 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin +16 more
wiley +1 more source
Disruption of histidine and energy homeostasis in chronic obstructive pulmonary disease
International Journal of COPD, 2019 Wenqi Diao1, Wassim W Labaki2, MeiLan K Han2, Larisa Yeomans3, Yihan Sun4, Zyad Smiley4, Jae Hyun Kim3, Cora McHugh4, Pingchao Xiang5, Ning Shen6, Xiaoyan Sun6, Chenxia Guo6, Ming Lu6, Theodore J Standiford2, Bei He*,7, Kathleen A Stringer*,2,4 ...
Diao W +15 more
doaj
Advanced Science, EarlyView.Hollow Co3O4/TiO2 heterojunctions are engineered for high‐throughput laser desorption/ionization mass spectrometry. The built‐in electric field drives efficient charge separation and photothermal conversion, while the hierarchical mesoporous network enables robust salt and protein tolerance.
Junyu Chen +8 more
wiley +1 more source
Histidine Targeting Heterobimetallic Ruthenium(II)-Gold(I) Complexes [PDF]
Inspired by the preferential, allosteric binding of RAPTA-T and auranofin to the nucleosome core particle, we describe the design and synthesis of a series of heterobimetallic ruthenium(II)-gold(I) complexes with varying spacer lengths ranging from four ...
Ortiz, Daniel +2 more
core +1 more source