Results 111 to 120 of about 308,029 (295)
OrganicsHeterocycle cores are widely used in medicinal chemistry for developing bioactive compounds. In this scenario, using cheap and accessible starting material to build these heterocycles is desirable to obtain new drug candidates for cost-efficient ...
Isis Apolo Silveira de Borba +3 more
doaj +1 more source
Fluorometric Determination of Histidine
Clinical Chemistry, 1969 Abstract An accurate and precise fluorometric procedure was developed for the determination of histidine based on the observation that o-phthalaldehyde forms a fluorophor with the analogous compound, histamine. The precision of the method was improved, and the fluorophor was stabilized for days by the addition of a phosphoric acid ...
J A, Ambrose +4 more
openaire +2 more sources
Harnessing Phase Separation for the Development of High‐Performance Hydrogels
Advanced Science, EarlyView.ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao +3 more
wiley +1 more source
A novel two-component signal transduction system in propionibacterium acnes and its association with a putative extracellular signalling peptide [PDF]
, 2011 Propionibacterium acnes, a resident micro-organism of human skin, is thought to be involved in the development of inflammatory acne, which is an exclusive human disease affecting more than 80% of the whole population. Quorum sensing is the regulation of
Guan, Shuang
core +3 more sources
Microbial CellTrypanosoma cruzi, the causing agent of Chagas disease, is the only known trypanosomatid pathogenic to humans having a complete histidine to glutamate pathway, which involves a series of four enzymatic reactions that convert histidine into downstream ...
Janaína de Freitas Nascimento +7 more
doaj +1 more source
Differences between β-Ala and Gly-Gly in the design of amino acids-based hydrogels
Beilstein Journal of Organic Chemistry, 2010 Despite the continuous interest in organogels and hydrogels of low molecular weight gelators (LMWG), establishing the relationship between the molecular structure and the gelation mechanism is still a challenge.
Andreea Pasc +3 more
doaj +1 more source
Mechanistic Understanding of Protein–MOF Integration Through Surfactant‐Driven Interfacial Design
Advanced Science, EarlyView.This study reveals how surfactant‐driven interfacial design governs the assembly and stability of protein@MOF composites. Using lipid‐based nonionic surfactants, we modulate protein–MOF interactions to improve encapsulation efficiency, MOF crystallization, and catalytic performance.
Ehsan Rashidniyaghi +4 more
wiley +1 more source
pKa Determination of a Histidine Residue in a Short Peptide Using Raman Spectroscopy
Molecules, 2019 Determining the pKa of key functional groups is critical to understanding the pH-dependent behavior of biological proteins and peptide-based biomaterials.
Brett H. Pogostin +3 more
doaj +1 more source
Nickel complexes of peptides containing histidine in the third position
, 2023 In this work, the combined applications of potentiometric, UV-vis and CD spectroscopy measurements on the Ni(II) complexes of GlyGlyHisGly and GlyGlyHisAla tetrapeptides were studied, in samples containing metal ions and ligand in equimolar ratio.
Verma, Bhavika
core
Advanced Science, EarlyView.SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio +6 more
wiley +1 more source