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Mechanism of activation and autophosphorylation of a histidine kinase. [PDF]
Commun ChemAbstractHistidine kinases (HK) are one of the main prokaryotic signaling systems. Two structurally conserved catalytic domains inside the HK enable autokinase, phosphotransfer, and phosphatase activities. Here, we focus on a detailed mechanistic understanding of the functional cycle of the WalK HK by a multi-scale simulation approach, consisting of ...
Kansari M +4 more
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Acid-Sensing Histidine Kinase With a Redox Switch. [PDF]
Front Microbiol, 2021 The EvgS/EvgA two-component signal transduction system inEscherichia coliis activated under mildly acidic pH conditions. Upon activation, this system induces the expression of a number of genes that confer acid resistance. The EvgS histidine kinase sensor has a large periplasmic domain that is required for perceiving acidic signals.
Inada S, Okajima T, Utsumi R, Eguchi Y.
europepmc +6 more sources
[Roles of Histidine Kinases and Histidine Phosphatases in Cancer].
Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2021 Phosphorylation is the most common and important post-translational modification of proteins, which plays an important role in the regulation of cell proliferation, differentiation, development and metabolism, and is closely related to the tumorigenesis and metastasis of cancer.
Lili Guo +3 more
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Determinants of Homodimerization Specificity in Histidine Kinases [PDF]
Journal of Molecular Biology, 2011 Two-component signal transduction pathways consisting of a histidine kinase and a response regulator are used by prokaryotes to respond to diverse environmental and intracellular stimuli. Most species encode numerous paralogous histidine kinases that exhibit significant structural similarity.
Ashenberg, Orr +3 more
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A Transmembrane Histidine Kinase Functions as a pH Sensor [PDF]
Biomolecules, 2020 The two-component system DesK-DesR regulates the synthesis of unsaturated fatty acids in the soil bacteria Bacillus subtilis. This system is activated at low temperature and maintains membrane lipid fluidity upon temperature variations. Here, we found that DesK—the transmembrane histidine kinase—also responds to pH and studied the mechanism of pH ...
Ana Bortolotti +8 more
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Phytochrome: If It Looks and Smells Like a Histidine Kinase, Is It a Histidine Kinase? [PDF]
Cell, 1997 That's all fine and good for cyanobacterial phytochrome, but the real excitement has to do with potential functional homology of plant phytochromes. Specifically, do plant phytochromes possess histidine kinase activity and what then do we make of phytochrome-associated serine kinase activity? As discussed by Quail 1997xQuail, P.H. BioEssay.
Tedd D. Elich, Joanne Chory
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Visualizing autophosphorylation in histidine kinases [PDF]
Nature Communications, 2014 Reversible protein phosphorylation is the most widespread regulatory mechanism in signal transduction. Autophosphorylation in a dimeric sensor histidine kinase is the first step in two-component signalling, the predominant signal-transduction device in bacteria.
Casino, Patricia +2 more
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Hybrid histidine kinases in pathogenic fungi [PDF]
Molecular Microbiology, 2015 SummaryHistidine kinases (HK) sense and transduce via phosphorylation events many intra‐ and extracellular signals in bacteria, archaea, slime moulds and plants. HK are also widespread in the fungal kingdom, but their precise roles in the regulation of physiological processes remain largely obscure.
Defosse, Tatiana +9 more
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Mechanism of Regulation of Receptor Histidine Kinases [PDF]
Structure, 2012 Bacterial transmembrane receptors regulate an intracellular catalytic output in response to extracellular sensory input. To investigate the conformational changes that relay the regulatory signal, we have studied the HAMP domain, a ubiquitous intracellular module connecting input to output domains.
Ferris, Hedda U. +8 more
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A Unique Sensor Histidine Kinase [PDF]
Journal of Bacteriology, 2009 Sporulation initiation in Bacillus species is controlled by an extended version of two-component signal transduction systems, termed phosphorelay ([4][1]). The cascade of His→Asp→His→Asp phosphotransfer is typically initiated by the ATP-dependent autophosphorylation of the histidine ...
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