Sequential conformational transitions and α-helical supercoiling regulate a sensor histidine kinase [PDF]
Nature Communications, 2017 Sensor histidine kinases (SHK) consist of sensor, linker and kinase modules and different models for SHK signal transduction have been proposed. Here the authors present nano- to millisecond time-resolved X-ray scattering measurements, which reveal a ...
Oskar Berntsson +19 more
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Recent Advances in Histidine Kinase-Targeted Antimicrobial Agents [PDF]
Frontiers in Chemistry, 2022 The prevalence of antimicrobial-resistant pathogens significantly limited the number of effective antibiotics available clinically, which urgently requires new drug targets to screen, design, and develop novel antibacterial drugs.
Hongtong Chen +11 more
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Structural mechanism of signal transduction in a phytochrome histidine kinase [PDF]
Nature Communications, 2022 In this study, authors have solved cryo-EM structures of a bacteriophytochrome in its dark-adapted and illuminated states. The structures reveal the structural mechanism for photoactivation of the phytochrome.
Weixiao Yuan Wahlgren +7 more
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PKM2 functions as a histidine kinase to phosphorylate PGAM1 and increase glycolysis shunts in cancer [PDF]
The EMBO JournalPhosphoglycerate mutase 1 (PGAM1) is a key node enzyme that diverts the metabolic reactions from glycolysis into its shunts to support macromolecule biosynthesis for rapid and sustainable cell proliferation.
Yang Wang +18 more
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Roles of Histidine Kinases and Histidine Phosphatases in Cancer
Chinese Journal of Lung Cancer, 2021 Phosphorylation is the most common and important post-translational modification of proteins, which plays an important role in the regulation of cell proliferation, differentiation, development and metabolism, and is closely related to the tumorigenesis ...
Yafang DONG +3 more
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Identification of histidine kinase inhibitors through screening of natural compounds to combat mastitis caused by Streptococcus agalactiae in dairy cattle [PDF]
Journal of Biological Engineering, 2023 Background Mastitis poses a major threat to dairy farms globally; it results in reduced milk production, increased treatment costs, untimely compromised genetic potential, animal deaths, and economic losses.
Rajesh Kumar Pathak, Jun-Mo Kim
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Bacterial Histidine Kinase and the Development of Its Inhibitors in the 21st Century [PDF]
AntibioticsBacterial histidine kinase (BHK) is a constituent of the two-component signaling (TCS) pathway, which is responsible for the regulation of a number of processes connected to bacterial pathogenicity, virulence, biofilm development, antibiotic resistance ...
Ragib Ahsan +7 more
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KdpD is a tandem serine histidine kinase that controls K+ pump KdpFABC transcriptionally and post-translationally [PDF]
Nature CommunicationsTwo-component systems, consisting of a histidine kinase and a response regulator, serve signal transduction in bacteria, often regulating transcription in response to environmental stimuli.
Jakob M. Silberberg +6 more
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Mechanism of activation and autophosphorylation of a histidine kinase [PDF]
Communications ChemistryHistidine kinases (HK) are one of the main prokaryotic signaling systems. Two structurally conserved catalytic domains inside the HK enable autokinase, phosphotransfer, and phosphatase activities. Here, we focus on a detailed mechanistic understanding of
Mayukh Kansari +4 more
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Atypical modes of bacterial histidine kinase signaling [PDF]
Molecular Microbiology, 2017 SummaryThe environment of a cell has a profound influence on its physiology, development and evolution. Accordingly, the capacity to sense and respond to physical and chemical signals in the environment is an important feature of cellular biology. In bacteria, environmental sensory perception is often regulated by two‐component signal transduction ...
Jonathan W Willett, S. Crosson
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