Roles of Histidine Kinases and Histidine Phosphatases in Cancer
Chinese Journal of Lung Cancer, 2021 Phosphorylation is the most common and important post-translational modification of proteins, which plays an important role in the regulation of cell proliferation, differentiation, development and metabolism, and is closely related to the tumorigenesis ...
Yafang DONG +3 more
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Identification of histidine kinase inhibitors through screening of natural compounds to combat mastitis caused by Streptococcus agalactiae in dairy cattle [PDF]
Journal of Biological Engineering, 2023 Background Mastitis poses a major threat to dairy farms globally; it results in reduced milk production, increased treatment costs, untimely compromised genetic potential, animal deaths, and economic losses.
Rajesh Kumar Pathak, Jun-Mo Kim
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Bacterial Histidine Kinase and the Development of Its Inhibitors in the 21st Century [PDF]
AntibioticsBacterial histidine kinase (BHK) is a constituent of the two-component signaling (TCS) pathway, which is responsible for the regulation of a number of processes connected to bacterial pathogenicity, virulence, biofilm development, antibiotic resistance ...
Ragib Ahsan +7 more
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Histidine Phosphorylation: Protein Kinases and Phosphatases [PDF]
International Journal of Molecular SciencesPhosphohistidine (pHis) is a reversible protein post-translational modification (PTM) that is currently poorly understood. The P-N bond in pHis is heat and acid-sensitive, making it more challenging to study than the canonical phosphoamino acids pSer, pThr, and pTyr. As advancements in the development of tools to study pHis have been made, the roles of
Jia Ning +5 more
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KdpD is a tandem serine histidine kinase that controls K+ pump KdpFABC transcriptionally and post-translationally [PDF]
Nature CommunicationsTwo-component systems, consisting of a histidine kinase and a response regulator, serve signal transduction in bacteria, often regulating transcription in response to environmental stimuli.
Jakob M. Silberberg +6 more
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Recent Advances in Histidine Kinase-Targeted Antimicrobial Agents [PDF]
Frontiers in Chemistry, 2022 The prevalence of antimicrobial-resistant pathogens significantly limited the number of effective antibiotics available clinically, which urgently requires new drug targets to screen, design, and develop novel antibacterial drugs.
Hongtong Chen +11 more
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Conformational sampling of CpxA: Connecting HAMP motions to the histidine kinase function.
PLoS ONE, 2018 In the histidine kinase family, the HAMP and DHp domains are considered to play an important role into the transmission of signal arising from environmental conditions to the auto-phosphorylation site and to the binding site of response regulator ...
Nathalie Duclert-Savatier +3 more
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Small Molecules from Medicinal Plant Iris tectorum as Histidine Kinase Inhibitor to Resensitize β-Lactam-Resistant Escherichia coli [PDF]
MoleculesBackground: Due to the widespread use of broad-spectrum antibiotics, the problem of antibiotic resistance has become an increasingly serious global threat.
Youqi Ji +8 more
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Mechanism of activation and autophosphorylation of a histidine kinase [PDF]
Communications ChemistryHistidine kinases (HK) are one of the main prokaryotic signaling systems. Two structurally conserved catalytic domains inside the HK enable autokinase, phosphotransfer, and phosphatase activities. Here, we focus on a detailed mechanistic understanding of
Mayukh Kansari +4 more
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Structural mechanism of signal transduction in a phytochrome histidine kinase [PDF]
Nature Communications, 2022 In this study, authors have solved cryo-EM structures of a bacteriophytochrome in its dark-adapted and illuminated states. The structures reveal the structural mechanism for photoactivation of the phytochrome.
Weixiao Yuan Wahlgren +7 more
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