Sequential conformational transitions and α-helical supercoiling regulate a sensor histidine kinase [PDF]
Nature Communications, 2017 Sensor histidine kinases (SHK) consist of sensor, linker and kinase modules and different models for SHK signal transduction have been proposed. Here the authors present nano- to millisecond time-resolved X-ray scattering measurements, which reveal a ...
Oskar Berntsson +19 more
doaj +2 more sources
Split histidine kinases enable ultrasensitivity and bistability in two-component signaling networks. [PDF]
PLoS Computational Biology, 2013 Bacteria sense and respond to their environment through signaling cascades generally referred to as two-component signaling networks. These networks comprise histidine kinases and their cognate response regulators.
Munia Amin +2 more
doaj +6 more sources
Structural Insights into the HWE Histidine Kinase Family: The Brucella Blue Light-Activated Histidine Kinase Domain [PDF]
Journal of Molecular Biology, 2016 In response to light, as part of a two-component system, the Brucella blue light-activated histidine kinase (LOV-HK) increases its autophosphorylation, modulating the virulence of this microorganism. The Brucella histidine kinase (HK) domain belongs to the HWE family, for which there is no structural information.
Rinaldi, Jimena Julieta +9 more
openaire +7 more sources
The Brown Algal Virus EsV-1 Particle Contains a Putative Hybrid Histidine Kinase [PDF]
, 2000 The Ectocarpus siliculosus virus, EsV-1, occurs worldwide in all populations of the filamentous marine brown alga E. siliculosus. We have screened an expression library of EsV-1 restriction fragments and identified a DNA clone with the potential to code ...
Delaroque, Nicolas +3 more
core +2 more sources
An Arabidopsis histidine kinase is essential for megagametogenesis [PDF]
Proceedings of the National Academy of Sciences, 2002 C yto k inin- I ndependent 1 (CKI1) belongs to a group of putative plant histidine kinases whose members do not appear to act as ethylene receptors. The deduced protein structure, combined with the observation that Arabidopsis callus cultures overexpressing
Linda G. Jones +5 more
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Cytokinin receptor: Just another histidine kinase [PDF]
Current Biology, 2001 The cytokinin family of plant hormones is involved in diverse aspects of plant growth and development in vivo and in culture. Two groups have recently shown that a two-component histidine kinase functions as a cytokinin receptor specifically required for vascular development.
Mark Estelle
openaire +4 more sources
Identification of histidine kinase inhibitors through screening of natural compounds to combat mastitis caused by Streptococcus agalactiae in dairy cattle. [PDF]
J Biol Eng, 2023 Background Mastitis poses a major threat to dairy farms globally; it results in reduced milk production, increased treatment costs, untimely compromised genetic potential, animal deaths, and economic losses.
Pathak RK, Kim JM.
europepmc +2 more sources
The role of polyproline motifs in the histidine kinase EnvZ [PDF]
PLOS ONE, 2018 Although distinct amino acid motifs containing consecutive prolines (polyP) cause ribosome stalling, which necessitates recruitment of the translation elongation factor P (EF-P), they occur strikingly often in bacterial proteomes. For example, polyP motifs are found in more than half of all histidine kinases in Escherichia coli K-12, which raises the ...
Magdalena Motz, Kirsten Jung
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KdpD is a tandem serine histidine kinase that controls K+ pump KdpFABC transcriptionally and post-translationally. [PDF]
Nat CommunTwo-component systems, consisting of a histidine kinase and a response regulator, serve signal transduction in bacteria, often regulating transcription in response to environmental stimuli.
Silberberg JM +6 more
europepmc +2 more sources
Bacterial Histidine Kinase and the Development of Its Inhibitors in the 21st Century. [PDF]
Antibiotics (Basel)Bacterial histidine kinase (BHK) is a constituent of the two-component signaling (TCS) pathway, which is responsible for the regulation of a number of processes connected to bacterial pathogenicity, virulence, biofilm development, antibiotic resistance ...
Ahsan R +7 more
europepmc +2 more sources