Split histidine kinases enable ultrasensitivity and bistability in two-component signaling networks. [PDF]
PLoS Computational Biology, 2013 Bacteria sense and respond to their environment through signaling cascades generally referred to as two-component signaling networks. These networks comprise histidine kinases and their cognate response regulators.
Munia Amin +2 more
doaj +11 more sources
Structural Insights into the HWE Histidine Kinase Family: The Brucella Blue Light-Activated Histidine Kinase Domain. [PDF]
Journal of Molecular Biology, 2016 In response to light, as part of a two-component system, the Brucella blue light-activated histidine kinase (LOV-HK) increases its autophosphorylation, modulating the virulence of this microorganism.
J. Rinaldi +9 more
semanticscholar +3 more sources
Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking [PDF]
Science Advances, 2016 Multidisciplinary study reveals the mechanism for second messenger–mediated regulation of a central bacterial cell cycle kinase. Histidine kinases are key components of regulatory networks in bacteria.
B. Dubey +6 more
semanticscholar +4 more sources
Small Molecules from Medicinal Plant Iris tectorum as Histidine Kinase Inhibitor to Resensitize β-Lactam-Resistant Escherichia coli [PDF]
MoleculesBackground: Due to the widespread use of broad-spectrum antibiotics, the problem of antibiotic resistance has become an increasingly serious global threat.
Youqi Ji +8 more
doaj +2 more sources
Determinants of Homodimerization Specificity in Histidine Kinases [PDF]
Journal of Molecular Biology, 2011 Two-component signal transduction pathways consisting of a histidine kinase and a response regulator are used by prokaryotes to respond to diverse environmental and intracellular stimuli. Most species encode numerous paralogous histidine kinases that exhibit significant structural similarity.
Ashenberg, Orr +3 more
openaire +7 more sources
The sensor histidine kinase PhcS participates in the regulation of quorum sensing-dependent virulence genes in Ralstonia pseudosolanacearum strain OE1-1 [PDF]
Microbiology SpectrumRalstonia pseudosolanacearum strain OE1-1 secretes methyl 3-hydroxymyristate (3-OH MAME) as a quorum-sensing (QS) signal. Strain OE1-1 senses the chemical by the sensor histidine kinase PhcS, leading to the activation of the LysR family transcriptional ...
Wakana Senuma +7 more
doaj +2 more sources
Segmental helical motions and dynamical asymmetry modulate histidine kinase autophosphorylation.
PLoS Biology, 2014 Histidine kinases (HKs) are dimeric receptors that participate in most adaptive responses to environmental changes in prokaryotes. Although it is well established that stimulus perception triggers autophosphorylation in many HKs, little is known on how ...
Ariel E Mechaly +3 more
doaj +2 more sources
A Dual Regulatory Role of the PhoU Protein in Salmonella Typhimurium
mBio, 2022 Bacteria utilize two-component regulatory systems to sense and respond to their surroundings. Unlike other two-component systems that directly sense through a sensory domain in the histidine kinase (HK), the PhoB/PhoR two-component system requires ...
Soomin Choi +3 more
doaj +1 more source
Acid-Sensing Histidine Kinase With a Redox Switch
Frontiers in Microbiology, 2021 The EvgS/EvgA two-component signal transduction system in Escherichia coli is activated under mildly acidic pH conditions. Upon activation, this system induces the expression of a number of genes that confer acid resistance.
Shinya Inada +3 more
doaj +1 more source
Histidine kinase MHZ1/OsHK1 interacts with ethylene receptors to regulate root growth in rice
Nature Communications, 2020 Ethylene plays essential roles during adaptive responses to water-saturating environments in rice, but knowledge of its signaling mechanism remains limited.
He Zhao +16 more
semanticscholar +1 more source