Results 221 to 230 of about 82,686 (281)

Role of N‐glycosylation as a determinant of ATG9A conformations and activity

Protein Science, Volume 35, Issue 1, January 2026.
Abstract Here, we investigate the effects of glycosylation at position N99 on the structural dynamics and lipid scrambling activity of ATG9A, a key autophagy protein, using microsecond all‐atom molecular dynamics simulations. ATG9A is an integral membrane protein involved in autophagosome biogenesis, and glycosylation at N99 has previously been ...
Mattia Utichi, Matteo Lambrughi, Henri‐Baptiste Marjault, Christian B. Borg, Sergio Esteban Echeverría, Kenji Maeda, Nicholas M. I. Taylor, Anders Gorm Pedersen, Elisa Fadda, Marja Jäättelä, Elena Papaleo   +10 more
wiley   +1 more source

Structural basis of molecular logic OR in a dual-sensor histidine kinase

, 2019
Heewhan Shin, Zhong Ren, Xiaoli Zeng, Sepalika Bandara, Xiaojing Yang   +4 more
openalex   +2 more sources

Activity‐restoring mutations in the histamine H3 receptor increase constitutive activity and reduce structural stability

Protein Science, Volume 35, Issue 1, January 2026.
Abstract The histamine H3 receptor (H3R) is a class A G protein‐coupled receptor (GPCR) that regulates neurotransmitter release in the central nervous system. Although structures of H3R in both inactive and active states have been elucidated, the functional roles of specific residues remain unclear.
Ami Nakajima, Hiroto Kaneko, Kosuke Oyama, Misumi Kuchiji, Ayane Itakura, Chiaki Arai, Mitsunori Shiroishi   +6 more
wiley   +1 more source

Phosphorylation induces altered protonation states and allosterically regulates Rac1–RhoGDI complex

Protein Science, Volume 35, Issue 1, January 2026.
Abstract Rho GTPases, critical for cellular functions like motility, are sequestered in an inactive GDP‐bound state by RhoGDI. While site‐specific RhoGDI phosphorylation is known to trigger selective GTPase release, the precise mechanisms remain elusive.
Krishnendu Sinha, Amit Kumawat, Hyunbum Jang, Ruth Nussinov, Suman Chakrabarty   +4 more
wiley   +1 more source

The histidine kinase NahK regulates pyocyanin production through the PQS system. [PDF]

J Bacteriol
Mendoza AG, Guercio D, Smiley MK, Sharma GK, Withorn JM, Hudson-Smith NV, Ndukwe C, Dietrich LEP, Boon EM.   +8 more
europepmc   +1 more source

Co-crystallization of a Histidine Kinase with Newly Discovered Inhibitors

, 2015
Francis Roushar
openalex   +1 more source

The BRAF‐specific region suppresses cysteine‐rich domain–lipid interaction independently of canonical autoinhibition by the 14‐3‐3 dimer

Protein Science, Volume 35, Issue 1, January 2026.
Abstract BRAF is a serine/threonine kinase and a central effector of the mitogen‐activated protein kinase (MAPK) signaling pathway, frequently mutated in cancer. Its activation is tightly controlled by autoinhibitory mechanisms that regulate membrane recruitment and dimerization.
Vasili Revazishvili, Alexia Morales, Bryn Baxter, Julian Grim, Ani Chakhrakia, Andres Jimenez Salinas, Kesaria Tevdorashvili, Angelica M. Riestra, Young Kwang Lee   +8 more
wiley   +1 more source

Probing bacterial transmembrane histidine kinase receptor–ligand interactions with natural and synthetic molecules

, 2010
Wai‐Leung Ng, Yunzhou Wei, Lark J. Perez, Jian-Ping Cong, Long Tao, Matthew Koch, M. F. SEMMELHACK, Ned S. Wingreen, Bonnie L. Bassler   +8 more
openalex   +1 more source

The structural heterogeneity of AKT autoinhibition

Protein Science, Volume 35, Issue 1, January 2026.
Abstract AKT is key to controlling cell growth through the PI3K/AKT/mTOR pathway. In the cytosol, in the absence of stimulus, AKT is autoinhibited to prevent uncontrolled activation. Increased AKT activity contributes to tumor growth by phosphorylating numerous downstream targets.
Liang Xu, Meryem Eren, Jackson Weako, Hyunbum Jang, Ozlem Keskin, Attila Gursoy, Ruth Nussinov   +6 more
wiley   +1 more source

Regulatory T Cells and Nanomaterials: Dual Perspectives in Therapeutics and Immunomodulation

Small Science, Volume 6, Issue 1, January 2026.
Tregs control immune tolerance but can also enable tumor escape. Nanomaterials can now expand or stabilize Tregs to treat autoimmunity and support transplantation or conversely disrupt tumor Tregs to boost antitumor immunity. We also discuss unintended Treg modulation by nanoparticles, safety and manufacturing challenges, and future translational ...
Yiyin Chen, Haibo Huang, Xiang Wang, Xinghao Yu, Ziyan Huang, Zhou Jin, Chen Chen, Yan Chen, Bruce R. Blazar, Yang Xu, Yunjie Lu   +10 more
wiley   +1 more source