Results 21 to 30 of about 1,192,564 (261)
Interaction of vitamin D, homocystein and dental diseases
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020 The 1,2,4-triazole nucleus is resistant to metabolism and is an important pharmacophore; it can increase solubility and improve the pharmacokinetic and pharmacodynamic profile of drugs.
Ye. O. Karpun +3 more
doaj +1 more source
Cell fate regulation governed by a repurposed bacterial histidine kinase. [PDF]
PLoS Biology, 2014 One of the simplest organisms to divide asymmetrically is the bacterium Caulobacter crescentus. The DivL pseudo-histidine kinase, positioned at one cell pole, regulates cell-fate by controlling the activation of the global transcription factor CtrA via ...
W Seth Childers +6 more
doaj +1 more source
Regulation of the chemotaxis histidine kinase CheA: A structural perspective.
Biochimica et Biophysica Acta - Biomembranes, 2020 Bacteria sense and respond to their environment through a highly conserved assembly of transmembrane chemoreceptors (MCPs), the histidine kinase (CheA), and the coupling protein CheW, hereafter termed "the chemosensory array".
A. Muok, A. Briegel, B. Crane
semanticscholar +1 more source
Nature Communications, 2020 Vibrio parahaemolyticus is the leading cause of seafood-borne diarrheal diseases. Experimental overproduction of a type 3 secretion system (T3SS1) in this pathogen leads to decreased intestinal colonization, which suggests that T3SS1 repression is ...
D. Gu +3 more
semanticscholar +1 more source
The Potential Functional Roles of NME1 Histidine Kinase Activity in Neuroblastoma Pathogenesis
International Journal of Molecular Sciences, 2020 Neuroblastoma is the most common extracranial solid tumor in childhood. Gain of chromosome 17q material is found in >60% of neuroblastoma tumors and is associated with poor patient prognosis.
K. Adam +3 more
semanticscholar +1 more source
Visualizing autophosphorylation in histidine kinases [PDF]
Nature Communications, 2014 Reversible protein phosphorylation is the most widespread regulatory mechanism in signal transduction. Autophosphorylation in a dimeric sensor histidine kinase is the first step in two-component signalling, the predominant signal-transduction device in bacteria.
Casino, Patricia +2 more
openaire +3 more sources
Interaction Analysis of a Two-Component System Using Nanodiscs. [PDF]
PLoS ONE, 2016 Two-component systems are the major means by which bacteria couple adaptation to environmental changes. All utilize a phosphorylation cascade from a histidine kinase to a response regulator, and some also employ an accessory protein.
Patrick Hörnschemeyer +4 more
doaj +1 more source
Activation of tyrosine kinases by mutation of the gatekeeper threonine. [PDF]
, 2008 Protein kinases targeted by small-molecule inhibitors develop resistance through mutation of the gatekeeper threonine residue of the active site. Here we show that the gatekeeper mutation in the cellular forms of c-ABL, c-SRC, platelet-derived growth ...
Azam, Mohammad +4 more
core +1 more source
Structure and dynamics of the E. coli chemotaxis core signaling complex by cryo-electron tomography and molecular simulations [PDF]
, 2020 To enable the processing of chemical gradients, chemotactic bacteria possess large arrays of transmembrane chemoreceptors, the histidine kinase CheA, and the adaptor protein CheW, organized as coupled core-signaling units (CSU). Despite decades of study,
Cassidy, Keith +8 more
core +1 more source
FEBS Open Bio, 2014 Two-component signal transduction systems (TCS), consisting of a sensor histidine protein kinase and its cognate response regulator, are an important mode of environmental sensing in bacteria.
Alisha Dhiman +3 more
doaj +1 more source