Recent Advances in Histidine Kinase-Targeted Antimicrobial Agents. [PDF]
Front Chem, 2022 The prevalence of antimicrobial-resistant pathogens significantly limited the number of effective antibiotics available clinically, which urgently requires new drug targets to screen, design, and develop novel antibacterial drugs.
Chen H +8 more
europepmc +2 more sources
Small Molecules from Medicinal Plant <i>Iris tectorum</i> as Histidine Kinase Inhibitor to Resensitize β-Lactam-Resistant <i>Escherichia coli</i>. [PDF]
MoleculesBackground: Due to the widespread use of broad-spectrum antibiotics, the problem of antibiotic resistance has become an increasingly serious global threat.
Ji Y +8 more
europepmc +2 more sources
How Can a Histidine Kinase Respond to Mechanical Stress? [PDF]
Front Microbiol, 2021 Bacteria respond to physical forces perceived as mechanical stress as part of their comprehensive environmental sensing strategy. Histidine kinases can then funnel diverse environmental stimuli into changes in gene expression through a series of ...
Kenney LJ.
europepmc +2 more sources
A Dual Regulatory Role of the PhoU Protein in Salmonella Typhimurium
mBio, 2022 Bacteria utilize two-component regulatory systems to sense and respond to their surroundings. Unlike other two-component systems that directly sense through a sensory domain in the histidine kinase (HK), the PhoB/PhoR two-component system requires ...
Soomin Choi +3 more
doaj +1 more source
Time-reversal symmetry breaking in the chemosensory array reveals mechanisms for dissipation-enhanced cooperative sensing [PDF]
Nature Communications 15, 8892 (2024), 2023 The Escherichia coli chemoreceptors form an extensive array that achieves cooperative and adaptive sensing of extracellular signals. The receptors control the activity of histidine kinase CheA, which drives a nonequilibrium phosphorylation-dephosphorylation reaction cycle for response regulator CheY.
arxiv +1 more source
Structural mechanism of signal transduction in a phytochrome histidine kinase. [PDF]
Nat Commun, 2022 In this study, authors have solved cryo-EM structures of a bacteriophytochrome in its dark-adapted and illuminated states. The structures reveal the structural mechanism for photoactivation of the phytochrome.
Wahlgren WY +7 more
europepmc +2 more sources
Cell fate regulation governed by a repurposed bacterial histidine kinase. [PDF]
PLoS Biology, 2014 One of the simplest organisms to divide asymmetrically is the bacterium Caulobacter crescentus. The DivL pseudo-histidine kinase, positioned at one cell pole, regulates cell-fate by controlling the activation of the global transcription factor CtrA via ...
W Seth Childers +6 more
doaj +1 more source
Inferring Compensatory Kinase Networks in Yeast using Prolog [PDF]
EPTCS 385, 2023, pp. 260-273, 2023 Signalling pathways are conserved across different species, therefore making yeast a model organism to study these via disruption of kinase activity. Yeast has 159 genes that encode protein kinases and phosphatases, and 136 of these have counterparts in humans.
arxiv +1 more source
The sensor histidine kinase PhcS participates in the regulation of quorum sensing-dependent virulence genes in <i>Ralstonia pseudosolanacearum</i> strain OE1-1. [PDF]
Microbiol SpectrRalstonia pseudosolanacearum strain OE1-1 secretes methyl 3-hydroxymyristate (3-OH MAME) as a quorum-sensing (QS) signal. Strain OE1-1 senses the chemical by the sensor histidine kinase PhcS, leading to the activation of the LysR family transcriptional ...
Senuma W +7 more
europepmc +2 more sources
Identification of a novel response regulator, Crr1, that is required for hydrogen peroxide resistance in Candida albicans [PDF]
, 2011 Peer ...
Bruce, Catherine R +6 more
core +9 more sources