Results 21 to 30 of about 82,686 (281)

Functional characterization of WalRK: A two-component signal transduction system from Bacillus anthracis

open access: yesFEBS Open Bio, 2014
Two-component signal transduction systems (TCS), consisting of a sensor histidine protein kinase and its cognate response regulator, are an important mode of environmental sensing in bacteria.
Alisha Dhiman   +3 more
doaj   +1 more source

Comparative analysis of two paradigm bacteriophytochromes reveals opposite functionalities in two-component signaling

open access: yesNature Communications, 2021
The bacteriophytochrome DrBphP from Deinococcus radiodurans shows high sequence homology to the histidine kinase Agp1 from Agrobacterium fabrum but lacks kinase activity.
Elina Multamäki   +12 more
doaj   +1 more source

Histidine residue 94 is involved in pH sensing by histidine kinase ArsS of Helicobacter pylori. [PDF]

open access: yesPLoS ONE, 2009
The ArsRS two-component system is the master regulator of acid adaptation in the human gastric pathogen Helicobacter pylori. Low pH is supposed to trigger the autophosphorylation of the histidine kinase ArsS and the subsequent transfer of the phosphoryl ...
Stefanie Müller   +2 more
doaj   +1 more source

How Can a Histidine Kinase Respond to Mechanical Stress?

open access: yesFrontiers in Microbiology, 2021
Bacteria respond to physical forces perceived as mechanical stress as part of their comprehensive environmental sensing strategy. Histidine kinases can then funnel diverse environmental stimuli into changes in gene expression through a series of ...
Linda J. Kenney
doaj   +1 more source

NikA/TcsC histidine kinase is involved in conidiation, hyphal morphology, and responses to osmotic stress and antifungal chemicals in Aspergillus fumigatus. [PDF]

open access: yesPLoS ONE, 2013
The fungal high osmolarity glycerol (HOG) pathway is composed of a two-component system (TCS) and Hog1-type mitogen-activated protein kinase (MAPK) cascade.
Daisuke Hagiwara   +7 more
doaj   +1 more source

Design, characterization and in vivo functioning of a light-dependent histidine protein kinase in the yeast Saccharomyces cerevisiae

open access: yesAMB Express, 2018
Helical alignment of the α-helical linker of the LOV (light-oxygen-voltage) domain of YtvA from Bacillus subtilis with the α-helical linker of the histidine-protein kinase domain of the Sln1 kinase of the phospho-relay system for osmoregulation of ...
Aleksandra Bury, Klaas J. Hellingwerf
doaj   +1 more source

Split histidine kinases enable ultrasensitivity and bistability in two-component signaling networks. [PDF]

open access: yesPLoS Computational Biology, 2013
Bacteria sense and respond to their environment through signaling cascades generally referred to as two-component signaling networks. These networks comprise histidine kinases and their cognate response regulators.
Munia Amin   +2 more
doaj   +1 more source

HAMP Domain Rotation and Tilting Movements Associated with Signal Transduction in the PhoQ Sensor Kinase

open access: yesmBio, 2015
HAMP domains are α-helical coiled coils that often transduce signals from extracytoplasmic sensing domains to cytoplasmic domains. Limited structural information has resulted in hypotheses that specific HAMP helix movement changes downstream enzymatic ...
Susana Matamouros   +2 more
doaj   +1 more source

NM23-H1: a Metastasis-Associated Gene

open access: yesTaiwanese Journal of Obstetrics & Gynecology, 2006
The protein product of nm23-H1 gene has activity of nucleoside diphosphate (NDP) kinase, which catalyzes the phosphorylation of nucleoside diphosphates to the corresponding nucleoside triphosphates.
Yi-Torng Tee   +4 more
doaj   +1 more source

Alterations in reversible protein histidine phosphorylation as intracellular signals in cardiovascular disease

open access: yesFrontiers in Pharmacology, 2015
Reversible phosphorylation of amino acid side chains in proteins is a frequently used mechanism in cellular signal transduction and alterations of such phosphorylation patterns are very common in cardiovascular diseases.
Thomas Wieland, Paul V. Attwood
doaj   +1 more source

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