Antigenic peptide binding by class I and class II histocompatibility proteins [PDF]
The recent determination of the structure of a class II MHC molecule complexed to a specific peptide reveals both similarities and differences with peptide binding by class I MHC.
L J, Stern, D C, Wiley
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Minors come of age: minor histocompatibility antigens and graft-versus-host disease [PDF]
Minor histocompatibility antigens (miHA) are responsible for the occurrence of graft-versus-host disease in the setting of a major histocompatibility complex matched sibling allogeneic stem cell transplantation.
Chao, Nelson J
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Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA [PDF]
Transformation of murine thymocytes by radiation leukemia virus is associated with reduced expression of the class I antigens encoded in the major histocompatibility complex (MHC) and increased methylation and altered restriction enzyme patterns of MHC ...
Boral, Anthony +11 more
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Structure and function of major histocompatibility complex class I antigens [PDF]
Major histocompatibility complex (MHC) class I molecules control the repertoire and function of CD8 T cells and NK cells, and both cell types are involved in transplant rejection. Understanding the regulatory role of MHC class I molecules is important in the design of better therapies.
Xian C, Li, Malini, Raghavan
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Recognition of major histocompatibility complex antigens on cultured human biliary epithelial cells by alloreactive lymphocytes [PDF]
We have developed an in vitro system to study the interactions between biliary epithelium and lymphocytes using cultured human biliary epithelial cells.
Demetris, AJ +5 more
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Differential phosphorylation of murine class I major histocompatibility antigens
Recent studies have shown that the H-2K and H-2D transplantation antigens are expressed differentially in different tissues of mouse. Our previous investigations also established that in thioglycolate-stimulated peritoneal macrophages the H-2Dk antigen exists in distinct cell surface and intracellular forms. These two forms are glycosylated differently.
W J, Hong, A, Van Le, D, Doyle
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Determination of a predictive cleavage motif for eluted major histocompatibility complex class II ligands [PDF]
CD4+ T cells have a major role in regulating immune responses. They are activated by recognition of peptides mostly generated from exogenous antigens through the major histocompatibility complex (MHC) class II pathway.
Dhanda, Sandeep Kumar +7 more
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Antigen-induced suppression: The role of Class I major histocompatibility antigens
The role of Class I major histocompatibility (MHC) antigens in the induction of specific suppression of graft rejection has been investigated. Two experimental transplantation models have been used ’ fully vascularized heterotopic Cardiac altografts in the mouse and fully vascularized orthotopic renal allografts in the rat.
K J, Wood, P J, Morris
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Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6 [PDF]
Gene cloning and sequencing of the HLA-B locus split antigens B38 (B16.1) and B39 (B16.2) allowed localization of their subtypic as well as their public specificities HLA-Bw4 or -Bw6 to the c~-helical region of the c~ 1 domain flanked by the amino acid ...
Engler-Blum, G. +5 more
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Mother-child histocompatibility and risk of rheumatoid arthritis and systemic lupus erythematosus among mothers. [PDF]
The study objective was to test the hypothesis that having histocompatible children increases the risk of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), possibly by contributing to the persistence of fetal cells acquired during ...
Barcellos, Lisa F +16 more
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