Results 1 to 10 of about 115,135 (343)

Determining the Quantitative Principles of T Cell Response to Antigenic Disparity in Stem Cell Transplantation [PDF]

Frontiers in Immunology, 2018
Alloreactivity compromising clinical outcomes in stem cell transplantation is observed despite HLA matching of donors and recipients. This has its origin in the variation between the exomes of the two, which provides the basis for minor ...
Ali Salman, Vishal Koparde, Charles E. Hall, Max Jameson-Lee, Catherine Roberts, Myrna Serrano, Badar AbdulRazzaq, Jeremy Meier, Caleb Kennedy, Masoud H. Manjili, Stephen R. Spellman, Dayanjan Wijesinghe, Shahrukh Hashmi, Greg Buck, Rehan Qayyum, Michael Neale, Jason Reed, Amir A. Toor   +17 more
doaj   +3 more sources

Canonical and Non-Canonical Functions of the Autophagy Machinery in MHC Restricted Antigen Presentation

Frontiers in Immunology, 2022
Macroautophagy delivers cytoplasmic constituents for lysosomal degradation. Since major histocompatibility complex (MHC) class II molecules sample peptides after lysosomal degradation for presentation to CD4+ T cells, it was originally described that ...
Christian Münz
doaj   +1 more source

Current research status of HLA in immune‐related diseases

Immunity, Inflammation and Disease, 2021
Human leukocyte antigen (HLA), also known as human major histocompatibility complex (MHC), is encoded by the HLA gene complex, and is currently known to have the highest gene density and the most polymorphisms among human chromosomal areas.
Bingnan Liu, Yuanyuan Shao, Rong Fu
doaj   +1 more source

Optimized Whole Genome Association Scanning for Discovery of HLA Class I-Restricted Minor Histocompatibility Antigens

Frontiers in Immunology, 2020
Patients undergoing allogeneic stem cell transplantation as treatment for hematological diseases face the risk of Graft-versus-Host Disease as well as relapse. Graft-versus-Host Disease and the favorable Graft-versus-Leukemia effect are mediated by donor
Kyra J. Fuchs, M. Willy Honders, Edith D. van der Meijden, Edith D. van der Meijden, Alwin E. Adriaans, Dyantha I. van der Lee, Margot J. Pont, Margot J. Pont, Ramin Monajemi, Szymon M. Kielbasa, Peter A. C. ’t Hoen, Peter A. C. ’t Hoen, Cornelis A. M. van Bergen, J. H. Frederik Falkenburg, Marieke Griffioen   +14 more
doaj   +1 more source

Comparative Reverse Vaccinology of Piscirickettsia salmonis, Aeromonas salmonicida, Yersinia ruckeri, Vibrio anguillarum and Moritella viscosa, Frequent Pathogens of Atlantic Salmon and Lumpfish Aquaculture

Vaccines, 2022
Marine finfish aquaculture is affected by diverse infectious diseases, and they commonly occur as co-infection. Some of the most frequent and prevalent Gram-negative bacterial pathogens of the finfish aquaculture include Piscirickettsia salmonis ...
Joy Chukwu-Osazuwa, Trung Cao, Ignacio Vasquez, Hajarooba Gnanagobal, Ahmed Hossain, Vimbai Irene Machimbirike, Javier Santander   +6 more
doaj   +1 more source

Assessment of roles for calreticulin in the cross-presentation of soluble and bead-associated antigens. [PDF]

PLoS ONE, 2012
Antigen cross-presentation involves the uptake and processing of exogenously derived antigens and their assembly with major histocompatibility complex (MHC) class I molecules.
Natasha Del Cid, Lianjun Shen, Janice Belleisle, Malini Raghavan   +3 more
doaj   +1 more source

Minors come of age: minor histocompatibility antigens and graft-versus-host disease [PDF]

, 2004
Minor histocompatibility antigens (miHA) are responsible for the occurrence of graft-versus-host disease in the setting of a major histocompatibility complex matched sibling allogeneic stem cell transplantation.
Chao, Nelson J
core   +1 more source

Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA [PDF]

, 1986
Transformation of murine thymocytes by radiation leukemia virus is associated with reduced expression of the class I antigens encoded in the major histocompatibility complex (MHC) and increased methylation and altered restriction enzyme patterns of MHC ...
Boral, Anthony, Buxbaum, Joel, Devlin, J., Flavell, Richard A., Kornreich, Ruth, Mellor, Andrew L., Meruelo, Daniel, Pampeno, Christine, Pellicer, Angel, Rossomando, Anthony, Silver, Jack L., Weiss, Elisabeth H.   +11 more
core   +1 more source

Antigen processing and presentation in cancer immunotherapy

Journal for ImmunoTherapy of Cancer, 2020
Background Knowledge about and identification of T cell tumor antigens may inform the development of T cell receptor-engineered adoptive cell transfer or personalized cancer vaccine immunotherapy.
Maxwell Y Lee, Cem Sievers, Clint T Allen, Jun W Jeon   +3 more
doaj   +1 more source

Immunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I

eLife, 2023
CD8+ T cell recognition of Mycobacterium tuberculosis (Mtb)-specific peptides presented on major histocompatibility complex class I (MHC-I) contributes to immunity to tuberculosis (TB), but the principles that govern presentation of Mtb antigens on MHC-I
Owen Leddy, Forest M White, Bryan D Bryson   +2 more
doaj   +1 more source