Results 11 to 20 of about 64,134 (148)

Canonical and Non-Canonical Functions of the Autophagy Machinery in MHC Restricted Antigen Presentation

Frontiers in Immunology, 2022
Macroautophagy delivers cytoplasmic constituents for lysosomal degradation. Since major histocompatibility complex (MHC) class II molecules sample peptides after lysosomal degradation for presentation to CD4+ T cells, it was originally described that ...
Christian Münz
doaj   +1 more source

Current research status of HLA in immune‐related diseases

Immunity, Inflammation and Disease, 2021
Human leukocyte antigen (HLA), also known as human major histocompatibility complex (MHC), is encoded by the HLA gene complex, and is currently known to have the highest gene density and the most polymorphisms among human chromosomal areas.
Bingnan Liu, Yuanyuan Shao, Rong Fu
doaj   +1 more source

Optimized Whole Genome Association Scanning for Discovery of HLA Class I-Restricted Minor Histocompatibility Antigens

Frontiers in Immunology, 2020
Patients undergoing allogeneic stem cell transplantation as treatment for hematological diseases face the risk of Graft-versus-Host Disease as well as relapse. Graft-versus-Host Disease and the favorable Graft-versus-Leukemia effect are mediated by donor
Kyra J. Fuchs, M. Willy Honders, Edith D. van der Meijden, Edith D. van der Meijden, Alwin E. Adriaans, Dyantha I. van der Lee, Margot J. Pont, Margot J. Pont, Ramin Monajemi, Szymon M. Kielbasa, Peter A. C. ’t Hoen, Peter A. C. ’t Hoen, Cornelis A. M. van Bergen, J. H. Frederik Falkenburg, Marieke Griffioen   +14 more
doaj   +1 more source

Comparative Reverse Vaccinology of Piscirickettsia salmonis, Aeromonas salmonicida, Yersinia ruckeri, Vibrio anguillarum and Moritella viscosa, Frequent Pathogens of Atlantic Salmon and Lumpfish Aquaculture

Vaccines, 2022
Marine finfish aquaculture is affected by diverse infectious diseases, and they commonly occur as co-infection. Some of the most frequent and prevalent Gram-negative bacterial pathogens of the finfish aquaculture include Piscirickettsia salmonis ...
Joy Chukwu-Osazuwa, Trung Cao, Ignacio Vasquez, Hajarooba Gnanagobal, Ahmed Hossain, Vimbai Irene Machimbirike, Javier Santander   +6 more
doaj   +1 more source

Antigenic peptide binding by class I and class II histocompatibility proteins [PDF]

Structure, 1994
The recent determination of the structure of a class II MHC molecule complexed to a specific peptide reveals both similarities and differences with peptide binding by class I MHC.
L J, Stern, D C, Wiley
openaire   +3 more sources

Assessment of roles for calreticulin in the cross-presentation of soluble and bead-associated antigens. [PDF]

PLoS ONE, 2012
Antigen cross-presentation involves the uptake and processing of exogenously derived antigens and their assembly with major histocompatibility complex (MHC) class I molecules.
Natasha Del Cid, Lianjun Shen, Janice Belleisle, Malini Raghavan   +3 more
doaj   +1 more source

Antigen processing and presentation in cancer immunotherapy

Journal for ImmunoTherapy of Cancer, 2020
Background Knowledge about and identification of T cell tumor antigens may inform the development of T cell receptor-engineered adoptive cell transfer or personalized cancer vaccine immunotherapy.
Maxwell Y Lee, Cem Sievers, Clint T Allen, Jun W Jeon   +3 more
doaj   +1 more source

Immunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I

eLife, 2023
CD8+ T cell recognition of Mycobacterium tuberculosis (Mtb)-specific peptides presented on major histocompatibility complex class I (MHC-I) contributes to immunity to tuberculosis (TB), but the principles that govern presentation of Mtb antigens on MHC-I
Owen Leddy, Forest M White, Bryan D Bryson   +2 more
doaj   +1 more source

Homotypic and heterotypic in cis associations of MHC class I molecules at the cell surface

Current Research in Immunology, 2022
Through the presentation of peptide antigens to cytotoxic T lymphocytes, major histocompatibility complex (MHC) class I molecules mediate the adaptive immune response against tumors and viruses.
Fernando M. Ruggiero, Sebastian Springer
doaj   +1 more source

The newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer

eLife, 2018
Devil Facial Tumour 2 (DFT2) is a recently discovered contagious cancer circulating in the Tasmanian devil (Sarcophilus harrisii), a species which already harbours a more widespread contagious cancer, Devil Facial Tumour 1 (DFT1).
Alison Caldwell, Rachel Coleby, Cesar Tovar, Maximilian R Stammnitz, Young Mi Kwon, Rachel S Owen, Marios Tringides, Elizabeth P Murchison, Karsten Skjødt, Gareth J Thomas, Jim Kaufman, Tim Elliott, Gregory M Woods, Hannah VT Siddle   +13 more
doaj   +1 more source