Manipulating IL-2 availability amid presentation of donor MHC antigens suppresses murine alloimmune responses by inducing regulatory T cells. [PDF]
BACKGROUND: Major histocompatibility complex (MHC) antigens are important for alloimmune responses as well as immune tolerance. Previous studies have shown that presentation of donor MHC antigens by donor-specific transfusion prior to or upon ...
Shuzi Zhang +4 more
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Frequency of Major Histocompatibility Antigens Class I in Mazandaran Province
Background and purpose: Major histocompatibility antigens are the most polymorphic components of the immune system. The purpose of this study was to determine the frequency of human leukocyte antigens (HLA) in a population in Mazandaran province, Iran ...
Fatemeh Toghani Hulari +4 more
doaj
Dendritic cells crosspresent antigens from live B16 cells more efficiently than from apoptotic cells and protect from melanoma in a therapeutic model. [PDF]
Dendritic cells (DC) are able to elicit anti-tumoral CD8(+) T cell responses by cross-presenting exogenous antigens in association with major histocompatibility complex (MHC) class I molecules.
Diana Matheoud +8 more
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Escape from the phagosome: the explanation for MHC-I processing of mycobacterial antigens?
Mycobacterium tuberculosis (Mtb) is thought to live in an altered phagosomal environment. In this setting, the mechanisms by which mycobacterial antigens access the major histocompatibility class I (MHC-I) processing machinery remain incompletely ...
Melanie eHarriff +5 more
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Aim. Human major histocompatibility complex class I antigens (HLA-A, -B, and -C) are heterodimetric molecules composed of a heavy chain non covalently associated with an invariant protein known as B2-microglobulin. Besides being expressed on the membrane
G. Murdaca, P. Cagnati, F. Puppo
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Structure and function of major histocompatibility complex class I antigens [PDF]
Major histocompatibility complex (MHC) class I molecules control the repertoire and function of CD8 T cells and NK cells, and both cell types are involved in transplant rejection. Understanding the regulatory role of MHC class I molecules is important in the design of better therapies.
Xian C, Li, Malini, Raghavan
openaire +2 more sources
Infectious Diseases and Immunity: Special Reference to Major Histocompatibility Complex
Human leukocyte antigens (HLAs) are an inherent system of alloantigens, which are the products of genes of the major histocompatibility complex (MHC).
Neeloo Singh, S. Agrawal, A.K. Rastogi
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Differential phosphorylation of murine class I major histocompatibility antigens
Recent studies have shown that the H-2K and H-2D transplantation antigens are expressed differentially in different tissues of mouse. Our previous investigations also established that in thioglycolate-stimulated peritoneal macrophages the H-2Dk antigen exists in distinct cell surface and intracellular forms. These two forms are glycosylated differently.
W J, Hong, A, Van Le, D, Doyle
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BACKGROUND: As being the first bacteria determined to be carcinogenic, Helicobacter pylori (H. pylori) is a pathogen localized in the stomach in more than half of the world population.
Sevim GÖNEN +4 more
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Antigen-induced suppression: The role of Class I major histocompatibility antigens
The role of Class I major histocompatibility (MHC) antigens in the induction of specific suppression of graft rejection has been investigated. Two experimental transplantation models have been used ’ fully vascularized heterotopic Cardiac altografts in the mouse and fully vascularized orthotopic renal allografts in the rat.
K J, Wood, P J, Morris
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