Results 31 to 40 of about 64,134 (148)

Expression of CD163 and major histocompatibility complex class I as diagnostic markers for idiopathic inflammatory myopathies

Arthritis Research & Therapy
Background To develop an inflammation-related immunohistochemistry marker-based algorithm that confers higher diagnostic ability for idiopathic inflammatory myopathies (IIMs) than IIM-related histopathologic features.
Byeongzu Ghang, So Hye Nam, Wonho Choi, Hwa Jung Kim, Jungsun Lee, Doo-Ho Lim, Soo Min Ahn, Ji Seon Oh, Seokchan Hong, Yong-Gil Kim, Chang-Keun Lee, Jinseok Kim, Bin Yoo, Soo Jeong Nam   +13 more
doaj   +1 more source

Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules

Frontiers in Immunology, 2023
Major Histocompatibility Complex class I (MHC-I) molecules display self, viral or aberrant epitopic peptides to T cell receptors (TCRs), which employ interactions between complementarity-determining regions with both peptide and MHC-I heavy chain ...
Georgia F. Papadaki, Georgia F. Papadaki, Omar Ani, Tyler J. Florio, Tyler J. Florio, Michael C. Young, Michael C. Young, Julia N. Danon, Julia N. Danon, Yi Sun, Yi Sun, Devin Dersh, Nikolaos G. Sgourakis, Nikolaos G. Sgourakis   +13 more
doaj   +1 more source

Antigen processing for MHC class II presentation via autophagy

Frontiers in Immunology, 2012
T cells recognize proteolytic fragments of antigens that are presented to them on major histocompatibility complex (MHC) molecules. MHC class I molecules present primarily products of proteasomal proteolysis to CD8+ T cells, while MHC class II molecules ...
Christian eMunz
doaj   +1 more source

HLA‐A*24:02 increase the risk of allopurinol‐induced drug reaction with eosinophilia and systemic symptoms in HLA‐B*58:01 carriers in a Korean population; a multicenter cross‐sectional case‐control study

Clinical and Translational Allergy, 2022
Background HLA‐B*58:01 is a well‐known risk factor for allopurinol‐induced severe cutaneous adverse reactions (SCARs). However, only a minority of HLA‐B*58:01 carriers suffer SCARs after taking allopurinol.
Mi‐Yeong Kim, James Yun, Dong‐Yoon Kang, Tae Hee Kim, Min‐Kyung Oh, Sunggun Lee, Min‐Gyu Kang, Young‐Hee Nam, Jeong‐Hee Choi, Min‐Suk Yang, Seung Seok Han, Hajeong Lee, Hyun‐Jai Cho, Jaeseok Yang, Kook‐Hwan Oh, Yon Su Kim, Jae Woo Jung, Kye Hwa Lee, Hye‐Ryun Kang   +18 more
doaj   +1 more source

Natural Killer Cells in Antibody Independent and Antibody Dependent HIV Control

Frontiers in Immunology, 2022
Infection with the human immunodeficiency virus (HIV), when left untreated, typically leads to disease progression towards acquired immunodeficiency syndrome.
Nicole F. Bernard, Nicole F. Bernard, Nicole F. Bernard, Nicole F. Bernard, Sanket Kant, Sanket Kant, Sanket Kant, Zahra Kiani, Zahra Kiani, Zahra Kiani, Cécile Tremblay, Cécile Tremblay, Franck P. Dupuy, Franck P. Dupuy   +13 more
doaj   +1 more source

A platform for mapping reactive cysteines within the immunopeptidome

Nature Communications
The major histocompatibility complex class I antigen presentation pathways play pivotal roles in orchestrating immune responses. Recent studies have begun to explore the therapeutic potential of cysteines within the immunopeptidome, such as the use of ...
Chenlu Zhang, Chen Zhou, Assa Magassa, Xiaokang Jin, Deyu Fang, Xiaoyu Zhang   +5 more
doaj   +1 more source

Sequences, annotation and single nucleotide polymorphism of the major histocompatibility complex in the domestic cat.

PLoS ONE, 2008
Two sequences of major histocompatibility complex (MHC) regions in the domestic cat, 2.976 and 0.362 Mbps, which were separated by an ancient chromosome break (55-80 MYA) and followed by a chromosomal inversion were annotated in detail.
Naoya Yuhki, James C Mullikin, Thomas Beck, Robert Stephens, Stephen J O'Brien   +4 more
doaj   +1 more source

Immunological Response during Pregnancy in Humans and Mares

Agriculture, 2022
The immunology of pregnancy deals with the immune responses of a mother and her fetus to each other. More knowledge has been acquired over the last decade to give insight into the complicated immunological processes that help the developing fetus to ...
Aleksandra Figarska, Olga Witkowska-Piłaszewicz   +1 more
doaj   +1 more source

Direct visualization of peptide/MHC complexes at the surface and in the intracellular compartments of cells infected in vivo by Leishmania major.

PLoS Pathogens, 2010
Protozoa and bacteria infect various types of phagocytic cells including macrophages, monocytes, dendritic cells and eosinophils. However, it is not clear which of these cells process and present microbial antigens in vivo and in which cellular ...
Eric Muraille, Pierre Gounon, Julie Cazareth, Johan Hoebeke, Christoph Lippuner, Ana Davalos-Misslitz, Toni Aebischer, Sylviane Muller, Nicolas Glaichenhaus, Evelyne Mougneau   +9 more
doaj   +1 more source

CD1-mediated immune responses in mucosal tissues: molecular mechanisms underlying lipid antigen presentation system

Experimental and Molecular Medicine, 2023
The cluster of differentiation 1 (CD1) molecule differs from major histocompatibility complex class I and II because it presents glycolipid/lipid antigens. Moreover, the CD1-restricted T cells that recognize these self and foreign antigens participate in
Seohyun Kim, Sumin Cho, Ji Hyung Kim
doaj   +1 more source