Results 41 to 50 of about 64,134 (148)

A step-by-step overview of the dynamic process of epitope selection by major histocompatibility complex class II for presentation to helper T cells [version 1; referees: 4 approved]

F1000Research, 2016
T cell antigen receptors (TCRs) expressed on cytotoxic or helper T cells can only see their specific target antigen as short sequences of peptides bound to the groove of proteins of major histocompatibility complex (MHC) class I, and class II ...
Scheherazade Sadegh-Nasseri
doaj   +1 more source

Transmembrane Helices Are an Overlooked Source of Major Histocompatibility Complex Class I Epitopes

Frontiers in Immunology, 2017
About a fourth of the human proteome is anchored by transmembrane helices (TMHs) to lipid membranes. TMHs require multiple hydrophobic residues for spanning membranes, and this shows a striking resemblance with the requirements for peptide binding to ...
Frans Bianchi, Johannes Textor, Geert van den Bogaart   +2 more
doaj   +1 more source

Kinetics of Major Histocompatibility Class I Antigen Presentation in Acute Infection [PDF]

The Journal of Immunology, 2009
Abstract Ag presentation within the regional lymph node is crucial for the initiation of CD8+ T cell responses following viral infection. The magnitude and quality of the CD8+ T cell response are regulated by the interplay between the size of the APC population and duration of Ag presentation.
Lay, Matthew D. H., Zhang, Lei, Ribeiro, Ruy M., Mueller, Scott N., Belz, Gabrielle T., Davenport, Miles P.   +5 more
openaire   +3 more sources

Non-canonical Functions of Macroautophagy Proteins During Endocytosis by Myeloid Antigen Presenting Cells

Frontiers in Immunology, 2018
Endocytosis by myeloid antigen presenting cells such as dendritic cells and macrophages regulates both antigen processing and major histocompatibility complex (MHC) molecule trafficking during antigen presentation.
Christian Münz
doaj   +1 more source

In silico and in vivo analysis of Toxoplasma gondii epitopes by correlating survival data with peptide–MHC-I binding affinities

International Journal of Infectious Diseases, 2016
Background: Protein antigens comprising peptide motifs with high binding affinity to major histocompatibility complex class I (MHC-I) molecules are expected to induce a stronger cytotoxic T-lymphocyte response and thus provide better protection against ...
Si-Yang Huang, Maria Risager Jensen, Carina Agerbo Rosenberg, Xing-Quan Zhu, Eskild Petersen, Thomas Vorup-Jensen   +5 more
doaj   +1 more source

Determining the Quantitative Principles of T Cell Response to Antigenic Disparity in Stem Cell Transplantation

Frontiers in Immunology, 2018
Alloreactivity compromising clinical outcomes in stem cell transplantation is observed despite HLA matching of donors and recipients. This has its origin in the variation between the exomes of the two, which provides the basis for minor ...
Ali Salman, Vishal Koparde, Charles E. Hall, Max Jameson-Lee, Catherine Roberts, Myrna Serrano, Badar AbdulRazzaq, Jeremy Meier, Caleb Kennedy, Masoud H. Manjili, Stephen R. Spellman, Dayanjan Wijesinghe, Shahrukh Hashmi, Greg Buck, Rehan Qayyum, Michael Neale, Jason Reed, Amir A. Toor   +17 more
doaj   +1 more source

Associative link of clinical manifestations of the secondary syphilis of skin and mucosa with histocompatibility antigens Class I

Vestnik Dermatologii i Venerologii, 2017
Sixty patients with different clinical symptoms of secondary syphilis (ulcer chancres, pustular syphilis, hypertrophic papules, widespread leukoderma and alopecia) were examined in order to study the distribution pattern of histocompatibility antigens of
S. V. Koshkin, T. V. Chermnyh, G. A. Zajceva, A. L. Evseeva, V. V. Ryabova   +4 more
doaj   +1 more source

Research Progress on Dendritic Cells in Hepatocellular Carcinoma Immune Microenvironments

Biomolecules
Dendritic cells (DCs) are antigen-presenting cells that play a crucial role in initiating immune responses by cross-presenting relevant antigens to initial T cells. The activation of DCs is a crucial step in inducing anti-tumor immunity. Upon recognition
Wenya Li, Guojie Chen, Hailin Peng, Qingfang Zhang, Dengyun Nie, Ting Guo, Yinxing Zhu, Yuhan Zhang, Mei Lin   +8 more
doaj   +1 more source

Endocytic Recycling of MHC Class I Molecules in Non-professional Antigen Presenting and Dendritic Cells

Frontiers in Immunology, 2019
Major histocompatibility complex class I (MHC I) molecules are glycoproteins that display peptide epitopes at the cell surface of nucleated cells for recognition by CD8+ T cells.
Sebastian Montealegre, Sebastian Montealegre, Sebastian Montealegre, Peter M. van Endert, Peter M. van Endert, Peter M. van Endert   +5 more
doaj   +1 more source

Pro-inflammatory responses after peptide-based cancer immunotherapy

Heliyon
Therapeutic vaccinations are designed to prevent cancer by inducing immune responses against tumor antigens. in cancer cells, tumor-associated antigens (TAA) or tumor-specific (mutated) derived peptides are presented within the clefts of main ...
Hanie Mahaki, Hassan Ravari, Gholamhossein Kazemzadeh, Elham Lotfian, Rahele Amir Daddost, Amir Avan, Hamed Manoochehri, Mohsen Sheykhhasan, Reihaneh Alsadat Mahmoudian, Hamid Tanzadehpanah   +9 more
doaj   +1 more source