Results 91 to 100 of about 453,877 (390)
Serafino Zappacosta: An Enlightened Mentor and Educator. [PDF]
, 2020 With this article, the authors aim to honor the memory of Serafino Zappacosta, who had been their mentor during the early years of their career in science.
Carbone, Ennio +10 more
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Involvement of Mhc Loci in immune responses that are not Ir-gene-controlled [PDF]
, 1982 Twenty-nine randomly chosen, soluble antigens, many of them highly complex, were used to immunize mice of two strains, C3H and B10.RIII. Lymphnode cells from the immunized mice were restimulated in vitro with the priming antigens and the proliferative ...
C. J. Kreo +28 more
core +1 more source
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Revista Portuguesa de Nefrologia e Hipertensão, 2022 For patients with end stage renal disease, kidney transplant offers significant survival and quality-of-life advantages compared with dialysis. But for patients seeking transplant who are highly sensitized, waiting times have traditionally been long and
Daniela Alfere +6 more
doaj +1 more source
AVIDa-hIL6: A Large-Scale VHH Dataset Produced from an Immunized Alpaca for Predicting Antigen-Antibody Interactions [PDF]
arXiv, 2023 Antibodies have become an important class of therapeutic agents to treat human diseases. To accelerate therapeutic antibody discovery, computational methods, especially machine learning, have attracted considerable interest for predicting specific interactions between antibody candidates and target antigens such as viruses and bacteria.
arxiv
Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies
Aging and Cancer, EarlyView.This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal +8 more
wiley +1 more source
BMC Genomics, 2018 Background Mutant peptides presented by MHC (major histocompatibility complex) Class II in cancer are important targets for cancer immunotherapy. Both animal studies and clinical trials in cancer patients showed that CD4 T cells specific to tumor-derived
Weijing Cai +6 more
doaj +1 more source
Expression of MHC II genes [PDF]
Current topics in microbiology and immunology. 290 (2005) Pages
147-70, Accession Number 16480042, 2006 Innate and adaptive immunity are connected via antigen processing and presentation (APP), which results in the presentation of antigenic peptides to T cells in the complex with the major histocompatibility (MHC) determinants. MHC class II (MHC II) determinants present antigens to CD4+ T cells, which are the main regulators of the immune response. Their
arxiv
A dynamical model of the adaptive immune system: effects of cells promiscuity, antigens and B-B interactions [PDF]
, 2015 We analyse a minimal model for the primary response in the adaptive immune system comprising three different players: antigens, T and B cells. We assume B-T interactions to be diluted and sampled locally from heterogeneous degree distributions, which mimic B cells receptors' promiscuity.
arxiv +1 more source
Sequence of the mouse Q4 class I gene and characterization of the gene product [PDF]
, 1988 The Q4 class I gene has been shown to participate in gene conversion events within the mouse major histocompatibility complex. Its complete genomic nucleotide sequence has been determined.
Bevec, Dorian +3 more
core +1 more source