Results 281 to 290 of about 453,877 (390)

Efficacy of immunotherapy remained in patients with recurrent/metastatic non‐small‐cell lung cancer after surgery with or without postoperative thoracic radiotherapy: a bi‐center retrospective study

Thoracic Cancer, EarlyView.
At some point after undergoing radical surgery for lung cancer with or without thoracic radiation therapy afterwards, the patient experienced disease progression. Response was observed after receiving immunotherapy. Abstract Purpose Since mediastinal lymph node dissection and radiotherapy (RT) have potential unclear impacts on pulmonary lymphatic ...
Yuqi Wu, Renda Li, Fengwei Tan, Jianzhong Cao, Nan Bi   +4 more
wiley   +1 more source

Nobiletin restores the intestinal barrier of HFD-induced obese mice by promoting MHC-II expression and lipid metabolism. [PDF]

Mol Med
Yang N, Pang YS, Zheng Y, Gong YJ, Ding WJ.   +4 more
europepmc   +1 more source

Disease Aggravation With Age in an Experimental Model of Multiple Sclerosis: Role of Immunosenescence

Aging Cell, Volume 24, Issue 5, May 2025.
Age‐related differences in EAE outcomes stem from combined peripheral and CNS factors. Key peripheral adaptive immunity changes include altered naïve/memory T cell ratios, Th1 skewing, increased suppressive Tregs, CD4+ T cell exhaustion, enhanced B cell antigen presentation, and reduced NK cell cytotoxicity.
María Dema, Herena Eixarch, Arnau Hervera, Mireia Castillo, Luisa M. Villar, Xavier Montalban, Carmen Espejo   +6 more
wiley   +1 more source

Influence of MyD88 and αβ T cells on mesenteric lymph node innate lymphoid cell populations during Toxoplasma gondii infection. [PDF]

PLoS One
Belmares-Ortega J, Zara Issoufou Kapran F, Denkers EY.   +2 more
europepmc   +1 more source

Characterization and evolution of MHC II genes in the European eel (Anguilla anguilla) [PDF]

, 2013
Bracamonte, Seraina E.
core  

Opportunities and Challenges of Population Pharmacogenomics

Annals of Human Genetics, EarlyView.
ABSTRACT Pharmacological responses can vary significantly among patients from different ethnogeographic backgrounds. This variability can, at least in part, be attributed to population‐specific genetic patterns in genes involved in drug absorption, distribution, metabolism, and excretion, as well as in genes associated with drug‐induced toxicity ...
Yitian Zhou, Yoomi Park, Mahamadou D. Camara, Volker M. Lauschke   +3 more
wiley   +1 more source

Glia Modulates Immune Responses in the Retina Through Distinct MHC Pathways. [PDF]

Glia
Intonti S, Kokona D, Zinkernagel MS, Enzmann V, Stein JV, Conedera FM.   +5 more
europepmc   +1 more source

Feedback regulation of VISTA and Treg by TNF‐α controls T cell responses in drug allergy

Allergy, EarlyView.
TNF‐α breaks immune tolerance by regulating the VISTA at early stage of the drug‐specific T‐cell response. The response of drug‐responsive effector T cells was negative feedback regulated by increasing Treg cells. This indicates that Treg agonists, rather than TNF‐α antagonists, could be used to treat patients with progressive SCARs.
Lele Sun, Qing Zhao, Suiting Ao, Tingting Liu, Zhenzhen Wang, Jiabao You, Zihao Mi, Yonghu Sun, Xiaotong Xue, Monday O. Ogese, Joshua Gardner, Xiaoli Meng, Dean J. Naisbitt, Hong Liu, Furen Zhang   +14 more
wiley   +1 more source

IFNγ Signaling Impairs Regulatory B Cell Function Resulting in Worse Control of Esophageal Food Allergy

Allergy, EarlyView.
We used patient samples and a murine model to understand the contribution of Bregs to EoE immunopathology. We find that Breg‐derived IL‐10 is important for controlling EoE, but that Breg expansion and function are impaired in this condition. We identify IFNγ as a key negative regulator of Breg function in mice and patients with EoE. Bregs, regulatory B
Rachel L. Clement, Julie Dilollo, Eric M. Rodríguez‐López, Cleandre M. Guerrier, David A. Hill   +4 more
wiley   +1 more source

Progesterone receptor-dependent downregulation of MHC class I promotes tumor immune evasion and growth in breast cancer. [PDF]

J Immunother Cancer
Tinoco JC, Saunders HI, Werner LR, Sun X, Chowanec EI, Heard A, Chalise P, Vahrenkamp JM, Wilson AE, Liu CX, Lei G, Wei J, Cros H, Mohammed H, Troester M, Perou C, Markiewicz MA, Gertz J, Balko JM, Hartman ZC, Hagan CR.   +20 more
europepmc   +1 more source