Results 31 to 40 of about 570,523 (273)

Metabolic regulation of gene expression by histone lactylation

Nature, 2019
The Warburg effect, which originally described increased production of lactate in cancer, is associated with diverse cellular processes such as angiogenesis, hypoxia, polarization of macrophages and activation of T cells.
Di Zhang, Zhanyun Tang, He Huang, He Huang, Guolin Zhou, Chang Cui, Yejing Weng, Wenchao Liu, Sunjoo Kim, Sangkyu Lee, Mathew Perez-Neut, Jun Ding, Daniel M. Czyż, Rong Hu, Z. Ye, Maomao He, Y. G. Zheng, H. Shuman, Lunzhi Dai, Lunzhi Dai, B. Ren, R. Roeder, L. Becker, Yingming Zhao   +23 more
semanticscholar   +1 more source

Cryo-EM structure of the nucleosome containing the ALB1 enhancer DNA sequence [PDF]

Open Biology, 2018
Pioneer transcription factors specifically target their recognition DNA sequences within nucleosomes. FoxA is the pioneer transcription factor that binds to the ALB1 gene enhancer in liver precursor cells, and is required for liver differentiation in ...
Yoshimasa Takizawa, Hiroki Tanaka, Shinichi Machida, Masako Koyama, Kazumitsu Maehara, Yasuyuki Ohkawa, Paul A. Wade, Matthias Wolf, Hitoshi Kurumizaka   +8 more
doaj   +1 more source

Nucleosome sliding can influence the spreading of histone modifications [PDF]

, 2021
Nucleosomes are the fundamental building blocks of chromatin that not only help in the folding of chromatin but also in carrying epigenetic information. It is known that nucleosome sliding is responsible for dynamically organizing chromatin structure and the resulting gene regulation.
arxiv   +1 more source

A length-dynamic Tonks gas theory of histone isotherms [PDF]

Europhysics Letters, 62, 753-759, (2003), 2002
We find exact solutions to a new one-dimensional (1D) interacting particle theory and apply the results to the adsorption and wrapping of polymers (such as DNA) around protein particles (such as histones). Each adsorbed protein is represented by a Tonks gas particle.
arxiv   +1 more source

Similarities between the Epstein-Barr Virus (EBV) Nuclear Protein EBNA1 and the Pioneer Transcription Factor FoxA: Is EBNA1 a “Bookmarking” Oncoprotein that Alters the Host Cell Epigenotype?

Pathogens, 2012
EBNA1, a nuclear protein expressed in all EBV-associated neoplasms is indispensable for the maintenance of the viral episomes in latently infected cells.
Hans Helmut Niller, Janos Minarovits
doaj   +1 more source

Involvement of HDAC1 and HDAC3 in the Pathology of Polyglutamine Disorders: Therapeutic Implications for Selective HDAC1/HDAC3 Inhibitors

Pharmaceuticals, 2014
Histone deacetylases (HDACs) enzymes, which affect the acetylation status of histones and other important cellular proteins, have been recognized as potentially useful therapeutic targets for a broad range of human disorders.
Elizabeth A. Thomas
doaj   +1 more source

Stochastic nucleosome disassembly mediated by remodelers and histone fragmentation [PDF]

arXiv, 2023
We construct and analyze monomeric and multimeric models of the stochastic disassembly of a single nucleosome. Our monomeric model predicts the time needed for a number of histone-DNA contacts to spontaneously break, leading to dissociation of a non-fragmented histone from DNA.
arxiv  

Histone acetyltransferase 1 is a succinyltransferase for histones and non‐histones and promotes tumorigenesis

EMBO reports, 2020
Lysine succinylation (Ksucc) is an evolutionarily conserved and widespread post-translational modification. Histone acetyltransferase 1 (HAT1) is a type B histone acetyltransferase, regulating the acetylation of both histone and non-histone proteins. However, the role of HAT1 in succinylation modulation remains unclear.
Guang Yang, Ying Yuan, Hongfeng Yuan, Jiapei Wang, Haolin Yun, Yu Geng, Man Zhao, Linhan Li, Yejing Weng, Zixian Liu, Jinyan Feng, Yanan Bu, Lei Liu, Bingnan Wang, Xiaodong Zhang   +14 more
openaire   +3 more sources

Accelerated Deficits of Spatial Learning and Memory Resulting From Prenatal Inflammatory Insult Are Correlated With Abnormal Phosphorylation and Methylation of Histone 3 in CD-1 Mice

Frontiers in Aging Neuroscience, 2019
Gestational infection causes various neurological deficits in offspring, such as age-related spatial learning and memory (SLM) decline. How inflammation causes age-related SLM dysfunction remains unknown.
Zi-Xing Wu, Zi-Xing Wu, Lei Cao, Xue-Wei Li, Wei Jiang, Xue-Yan Li, Jing Xu, Fang Wang, Gui-Hai Chen   +8 more
doaj   +1 more source

Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

Science, 2010
A Lot of HOTAIR The roles of several classes of small (
Miao-Chih Tsai, Ohad Manor, Y. Wan, N. Mosammaparast, Jordon K. Wang, F. Lan, Yang Shi, E. Segal, Howard Y. Chang   +8 more
semanticscholar   +1 more source