Results 51 to 60 of about 617,156 (199)

Epigenetic modification in chromatin machinery and its deregulation in pediatric brain tumors: Insight into epigenetic therapies

Epigenetics, 2017
Malignancies are characterized by the reprogramming of epigenetic patterns. This reprogramming includes gains or losses in DNA methylation and disruption of normal patterns of covalent histone modifications, which are associated with changes in chromatin
Eleonore Maury, Rintaro Hashizume
doaj   +1 more source

Multiple Site-Specific One-Pot Synthesis of Two Proteins by the Bio-Orthogonal Flexizyme System

Frontiers in Bioengineering and Biotechnology, 2020
Lysine acetylation is a reversible post-translational modification (PTM) vastly employed in many biological events, including regulating gene expression and dynamic transitions in chromatin remodeling.
Qiuyun Xiao, Qiuyun Xiao, Zihan Liu, Xuan Zhao, Hai Xiong   +4 more
doaj   +1 more source

Involvement of HDAC1 and HDAC3 in the Pathology of Polyglutamine Disorders: Therapeutic Implications for Selective HDAC1/HDAC3 Inhibitors

Pharmaceuticals, 2014
Histone deacetylases (HDACs) enzymes, which affect the acetylation status of histones and other important cellular proteins, have been recognized as potentially useful therapeutic targets for a broad range of human disorders.
Elizabeth A. Thomas
doaj   +1 more source

Combination Therapy With Histone Deacetylase Inhibitors (HDACi) for the Treatment of Cancer: Achieving the Full Therapeutic Potential of HDACi

Frontiers in Oncology, 2018
Genetic and epigenetic changes in DNA are involved in cancer development and tumor progression. Histone deacetylases (HDACs) are key regulators of gene expression that act as transcriptional repressors by removing acetyl groups from histones.
Amila Suraweera, K. O'Byrne, D. Richard
semanticscholar   +1 more source

Lysine methyltransferase SETD6 modifies histones on a glycine-lysine motif

Epigenetics, 2020
Although central to regulating the access to genetic information, most lysine methyltransferases remain poorly characterised relative to other family of enzymes. Herein, I report new substrates for the lysine methyltransferase SETD6.
Olivier Binda
doaj   +1 more source

The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy

Frontiers in Cell and Developmental Biology, 2020
Genetic mutations and abnormal gene regulation are key mechanisms underlying tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores, represent the basic units of chromatin. The fifth amino group (Nε) of histone lysine residues is a
Guo Li, Yuan Tian, Wei-Guo Zhu
semanticscholar   +1 more source

H3K36 Methylation Regulates Nutrient Stress Response in Saccharomyces cerevisiae by Enforcing Transcriptional Fidelity

Cell Reports, 2017
Set2-mediated histone methylation at H3K36 regulates diverse activities, including DNA repair, mRNA splicing, and suppression of inappropriate (cryptic) transcription.
Stephen L. McDaniel, Austin J. Hepperla, Jie Huang, Raghuvar Dronamraju, Alexander T. Adams, Vidyadhar G. Kulkarni, Ian J. Davis, Brian D. Strahl   +7 more
doaj   +1 more source

Extraction, Identification, Modification, and Antibacterial Activity of Histone from Immature Testis of Atlantic salmon

Marine Drugs, 2020
In the present study, histone from immature testis of Atlantic salmon was extracted and identified, and its antibacterial activity after enzymolysis was investigated.
Boyu Fu, Hong Lin, Tushar Ramesh Pavase, Nasha Mi, Jianxin Sui   +4 more
doaj   +1 more source

Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

Nature Communications, 2018
The recently discovered histone post-translational modification crotonylation connects cellular metabolism to gene regulation. Its regulation and tissue-specific functions are poorly understood.
R. Fellows, J. Denizot, Claudia Stellato, A. Cuomo, Payal Jain, E. Stoyanova, Szabina Balázsi, Zoltán Hajnády, A. Liebert, Juri Kazakevych, Hector Blackburn, R. Corrêa, J. Fachi, F. T. Sato, W. R. Ribeiro, C. Ferreira, Hélène Perée, M. Spagnuolo, Raphaël Mattiuz, Csaba Matolcsi, Joana Guedes, J. Clark, M. Veldhoen, T. Bonaldi, M. Vinolo, P. Varga-Weisz   +25 more
semanticscholar   +1 more source

The embryonic linker histone dBigH1 alters the functional state of active chromatin [PDF]

, 2020
Paula Climent‐Cantó, Albert Carbonell, Miloš Tatarski, Óscar Reina, Paula Bujosa, Jofre Font-Mateu, Jordi Bernués, Miguel Beato, Fernando Azorı́n   +8 more
openalex   +1 more source