Results 51 to 60 of about 570,523 (273)
Chaperones and Beyond as Key Players in Pluripotency Maintenance
Frontiers in Cell and Developmental Biology, 2019 Pluripotency is orchestrated by distinct players and chaperones and their partners have emerged as pivotal molecules in proteostasis control to maintain stemness.
Camila Felix de Lima Fernandes +4 more
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A computational model for histone mark propagation reproduces the distribution of heterochromatin in different human cell types [PDF]
PLoS ONE 8(9): e73818, 2013 Chromatin is a highly compact and dynamic nuclear structure that consists of DNA and associated proteins. The main organizational unit is the nucleosome, which consists of a histone octamer with DNA wrapped around it. Histone proteins are implicated in the regulation of eukaryote genes and they carry numerous reversible post-translational modifications
arxiv +1 more source
Role of histone tyrosines in nucleosome formation and histone-histone interaction.
Journal of Biological Chemistry, 1984 We have studied the functional properties of iodinated histones. Isolated, denatured histones were iodinated at trace levels and then renatured together with carrier histones and high molecular weight DNA to form nucleohistone. Nucleosomes were prepared from the reconstitute using micrococcal nuclease, and the relative representations of the individual
H G Martinson, A M Kleinschmidt
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Cell Reports, 2017 Set2-mediated histone methylation at H3K36 regulates diverse activities, including DNA repair, mRNA splicing, and suppression of inappropriate (cryptic) transcription.
Stephen L. McDaniel +7 more
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A short guide to histone deacetylases including recent progress on class II enzymes
Experimental and Molecular Medicine, 2020 The interaction between histones and DNA is important for eukaryotic gene expression. A loose interaction caused, for example, by the neutralization of a positive charge on the histone surface by acetylation, induces a less compact chromatin structure ...
Suk‐Youl Park, Jeong-Sun Kim
semanticscholar +1 more source
Histones and histone variant families in prokaryotes
Nature CommunicationsAbstractHistones are important chromatin-organizing proteins in eukaryotes and archaea. They form superhelical structures around which DNA is wrapped. Recent studies have shown that some archaea and bacteria contain alternative histones that exhibit different DNA binding properties, in addition to highly divergent sequences.
Samuel Schwab +8 more
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Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11
FEBS Open Bio, 2020 Ferroptosis is a type of adaptive cell death driven by cellular metabolism and iron‐dependent lipid peroxidation. Though multiple genes (including SLC7A11 and GPX4) have been demonstrated to play key roles in ferroptosis, little is known about the ...
Yishu Wang +7 more
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Journal of Developmental Biology, 2021 Epigenetic modifications regulate gene expression for development, immune response, disease, and other processes. A major role of epigenetics is to control the dynamics of chromatin structure, i.e., the condensed packaging of DNA around histone proteins ...
Rwik Sen, Christopher Barnes
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Pharmacological Inhibition of LSD1 for Cancer Treatment
Molecules, 2018 Lysine-specific demethylase 1A (LSD1, also named KDM1A) is a demethylase that can remove methyl groups from histones H3K4me1/2 and H3K9me1/2. It is aberrantly expressed in many cancers, where it impedes differentiation and contributes to cancer cell ...
Guan-Jun Yang +4 more
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Early Life Stress- and Drug-Induced Histone Modifications Within the Ventral Tegmental Area
Frontiers in Cell and Developmental Biology, 2020 Psychiatric illnesses are a major public health concern due to their prevalence and heterogeneity of symptom presentation resulting from a lack of efficacious treatments.
Ryan D. Shepard, Fereshteh S. Nugent
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