Results 161 to 170 of about 115,732 (260)

High glucose-induced PLCG1 histone acetylation to promote ferroptosis by LAMP2A/HSPA8 in a diabetic nephropathy model. [PDF]

Front Pharmacol
Ge J, Wang Z, Xu T, Jiang R, Zhang X.
europepmc   +1 more source

On the biological role of histone acetylation [PDF]

Biochemical Journal, 1990
openaire   +2 more sources

KAT2A Promotes the Progression of Renal Cell Carcinoma by Regulating the Succinylation of SERPINE2

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Epithelial‐mesenchymal transition (EMT) and angiogenesis are critical drivers of renal cell carcinoma (RCC) progression, yet their upstream regulatory mechanisms remain incompletely understood. This study aimed to investigate the role of KAT2A in RCC and elucidate the underlying molecular mechanism by which it promotes tumor progression.
Chang‐Cheng Liu, Xue‐Dong Li
wiley   +1 more source

Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture. [PDF]

Sci Adv
Fukai YT, Kujirai T, Wakamori M, Kanamura S, Yamauchi L, Zeraati S, Morita S, Tanegashima C, Kadota M, Shirouzu M, Kurumizaka H, Umehara T, Kawaguchi K.   +12 more
europepmc   +1 more source

Ion Activation Methods for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley   +1 more source

Author Correction: SOX2 drives esophageal squamous carcinoma by reprogramming lipid metabolism and histone acetylation landscape. [PDF]

Nat Commun
Wang Z, Dai R, Kang L, Yang H, Chen Z, He J, Shu L, Zhong Y, Zhang Y, Hua Z, Huang Y, Jiang Y, Li J, Xu L, Lan F, Lin SH, Wong J.   +16 more
europepmc   +1 more source

Recent Advances (2023–2025) of Capillary Electrophoresis‐Mass Spectrometry (CE‐MS) for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu, David A. Alvarez Rodriguez, Noah Gould, Alexander R. Ivanov, Kevin Jooß, Liangliang Sun   +5 more
wiley   +1 more source

Disruption of histone acetylation homeostasis reveals multilayered chromatin regulation for transcriptional resiliency. [PDF]

Epigenetics Chromatin
Venu V, Small EM, Roth C, Adikari SH, Vlot AHC, Sullivan KA, Abeyratne CR, Jacobson D, Starkenburg SR, Sanbonmatsu KY, Steadman CR.   +10 more
europepmc   +1 more source

Histone Acetylation and Deacetylation

Molecular & Cellular Proteomics, 2002
Kangling Zhang, Katherine E. Williams, Lan Huang, Peter Yau, Joseph S. Siino, E. Morton Bradbury, Patrick R. Jones, Michael J. Minch, Alma L. Burlingame   +8 more
openaire   +1 more source

Recent Advances in Top‐Down Proteomics for Single‐Cell Research

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley   +1 more source