Results 281 to 290 of about 189,363 (327)

SETD2 suppresses tumorigenesis in a KRAS^G12C-driven lung cancer model, and its catalytic activity is regulated by histone acetylation. [PDF]

Elife
Mack RJ, Flores NM, Fox GC, Dong H, Cebeci M, Hausmann S, Chasan T, Dowen JM, Strahl BD, Mazur PK, Gozani O.   +10 more
europepmc   +1 more source

BRD9 inhibition as potential treatment option for testicular germ cell tumors

Andrology, EarlyView.
Abstract Background Testicular germ cell tumors (TGCT) are the predominant tumor in younger males. Usually, 5‐year survival rates are quite high, but 15–20% of patients with metastatic non‐seminomas are resistant to standard cisplatin‐based therapy.
Aylin Hansen, Christine Sanders, Florian Fronhoffs, Kai Funke, Glen Kristiansen, Hubert Schorle   +5 more
wiley   +1 more source

PI3Kβ moonlights as a protein kinase: driving fatty acid metabolism and histone acetylation in cancer. [PDF]

Cancer Biol Med
Duan Y, Liu J, Xu J, Fang J.
europepmc   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Comprehensive analysis of diagnostic biomarkers related to histone acetylation in acute myocardial infarction. [PDF]

BMC Med Genomics
Li M, Yang L, Wang Y, Zhang L.
europepmc   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Maternal exercise improves vascular function in hypertensive offspring via A‐kinase anchoring protein 150 gene (Akap5) epigenetic modifications

British Journal of Pharmacology, EarlyView.
Background and Purpose Regular physical activity is an effective non‐pharmacological approach to hypertension management and maternal exercise improves offspring cardiovascular health, although mechanisms remain unclear. A‐kinase anchoring protein 150 (AKAP150) targets protein kinase Cα to L‐type Ca2+ channels (CaV1.2), enhancing vascular tone in ...
Fang Qiu, Yanyan Zhang, Meiling Shan, Jiaqi Cao, Zihan Fan, Zhaoxia Xu, Xiaozhen Ding, Xiaodong Liu, Lijun Shi   +8 more
wiley   +1 more source

Mechanism of crosstalk between DNA methylation and histone acetylation and related advances in diagnosis and treatment of premature ovarian failure. [PDF]

Epigenetics
Li J, Liao Q, Guo Y, Zhang J, Zhang R, Liu Q, Liu H.   +6 more
europepmc   +1 more source

Comprehensive multi-omics analysis of histone acetylation modulators identifies ASH1L as a novel aggressive marker for osteosarcoma. [PDF]

Discov Oncol
Ni C, Sun Q, Yin H.
europepmc   +1 more source

High levels of histone acetylation modifications promote the formation of PGCs. [PDF]

Poult Sci
Zhao Z, Wu Y, Cheng F, Wang Z, Geng Q, Niu Y, Zuo Q, Zhang Y.   +7 more
europepmc   +1 more source