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Histone acetylation: chromatin in action
Trends in Biochemical Sciences, 1997Histone acetylation acts as a landmark and determinant for chromatin function. Active roles in the transcription and assembly of chromatin have been discovered for histone acetyltransferases and deacetylases. This review highlights these roles and discusses their significance for the maintenance of cell differentiation.
P A, Wade, D, Pruss, A P, Wolffe
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Acetylation of histones in nucleosomes
Molecular and Cellular Biochemistry, 1982A short review is given on the biochemistry of histone acetylation. Sites of acetylation in nucleosomal histones and enzymes involved in acetylation and deacetylation are discussed. Studies relating to the influence of these modifications on the structure of nucleosomes and chromatin are especially emphasized in this article.
D, Doenecke, D, Gallwitz
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Beyond histone acetylation—writing and erasing histone acylations
Current Opinion in Structural Biology, 2018Histone post-translational modifications are crucial epigenetic mechanisms regulating a variety of biological events. Besides histone lysine acetylation, a repertoire of acylation types have been identified, including formylation, propionylation, butyrylation, crotonylation, 2-hydroxyisobutyrylation, β-hydroxybutyrylation, succinylation, malonylation ...
Shuai, Zhao, Xingrun, Zhang, Haitao, Li
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Histone acetylation: facts and questions
Chromosoma, 1994The DNA of eukaryotic cells is organized in a complex with proteins, either as interphase chromatin or mitotic chromosomes. Nucleosomes, the structural subunits of chromatin, have long been considered as static structures, incompatible with processes occurring in chromatin.
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In Vitro Histone Acetylation Assay
Current Protocols in Pharmacology, 2017AbstractAcetylation is a core cellular process involved in maintaining genomic integrity, gene regulation, and metabolism. Histone acetyltransferases (HATs) are an enzyme family that regulates these processes by catalyzing the transfer of an acetyl moiety onto target proteins.
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Histone acetylation regulated by histone deacetylases during spermatogenesis
AndrologyAbstractBackgroundPhysical, chemical, and biological factors in the environment constantly influence in vivo and in vitro biological processes, including diverse histone modifications involved in cancer and metabolism. However, the intricate mechanisms of acetylation regulation remain poorly elucidated. In mammalian spermatogenesis, acetylation plays a
Xiangying Ou +4 more
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Histone Acetylation and Deacetylation
2012Gene expression in eukaryotic organisms can be influenced by a host of internal and external stimuli. The magnitude and duration of the response can often determine the effect of a diverse array of biological functions, many of which can be driven by gene expression.
Daniel M. Fass +5 more
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