Results 91 to 100 of about 182,599 (256)

Maternal gut microbiota‐derived daidzein prevents osteoporosis in female offspring following prenatal prednisone exposure

iMeta, EarlyView.
Prenatal prednisone therapy (PPT)/prenatal prednisone exposure (PPE) induces long bone dysplasia, reduced peak bone mass (PBM), and increased osteoporosis susceptibility in female offspring. Maternal gut microbiota metabolite daidzein (DAI) mediates PPE‐induced osteoporosis susceptibility in female adult offspring.
Chi Ma, Hangyuan He, Kunpeng Wang, Juanjuan Guo, Liang Liu, Yuting Chen, Bin Li, Hao Xiao, Xufeng Li, Xiaoqian Lu, Tingting Wang, Yinxian Wen, Hui Wang, Liaobin Chen   +13 more
wiley   +1 more source

Multiomics Reveal Associations Between CpG Methylation, Histone Modifications and Transcription in a Species That has Lost DNMT3, the Colorado Potato Beetle

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Despite lacking DNMT3, EM‐seq revealed CpG methylation in the Colorado potato beetle. CUT&Tag analysis showed an association of H3K36me3 and H3K27ac with transcription, with H3K36me3 mirroring CpG methylation, demonstrating epigenetic flexibility.
Zoe M. Länger, Elisa Israel, Jan Engelhardt, Agata I. Kalita, Claudia I. Keller Valsecchi, Joachim Kurtz, Sonja J. Prohaska   +6 more
wiley   +1 more source

Human TFIIIC Relieves Chromatin-Mediated Repression of RNA Polymerase III Transcription and Contains an Intrinsic Histone Acetyltransferase Activity [PDF]

, 1999
Tapas K. Kundu, Zhengxin Wang, Robert G. Roeder   +2 more
openalex   +1 more source

EP300 Modulates MCM8 Transcription and Augments the Malignant Phenotype of Hepatitis B Virus–Positive Hepatocellular Carcinoma Cells

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Chronic infection with the hepatitis B virus (HBV) remains one of the primary drivers of the development of hepatocellular carcinoma (HCC), a highly aggressive malignancy with a grim prognosis. This study focused on the role of E1A‐binding protein p300 (EP300) in the malignant phenotype of HBV‐positive HCC cells and its functional mechanism ...
Fang Xue, Tian‐Feng Sun
wiley   +1 more source

E1A12S-mediated Activation of the Adenovirus Type 12 E2 Promoter Depends on the Histone Acetyltransferase Activity of p300/CBP [PDF]

, 2000
Peter Fax, Oliver Lehmkühler, Claudine Kühn, Helmut Esche, Dieter Brockmann   +4 more
openalex   +1 more source

Protein Post‐Translational Modification‐Mediated Control of Type I Interferon Cascade Signaling

Medicine Bulletin, EarlyView.
ABSTRACT Type I interferons (IFN‐Is) constitute the primary defense mechanism against pathogenic infections in the human body. The antiviral signaling mediated by IFN‐I is integral to the host immune response. Nevertheless, an imbalance in IFN‐I function can perturb the organism’s homeostasis. Consequently, it is imperative for the body to meticulously
Xiangjie Chen, Qiao Cheng, Fang Gong, Hui Zheng   +3 more
wiley   +1 more source

Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders

Medicinal Research Reviews, EarlyView.
ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar, Tobias Werner, Mihajlo Gajic, Holger Stark, Bassem Sadek   +4 more
wiley   +1 more source

A comprehensive review on adaptive plasticity and recovery mechanisms post‐acquired brain injury

Neuroprotection, EarlyView.
This figure illustrates the dynamic process of neurogenesis following brain injury, focusing on the roles of neural stem and progenitor cells at the injury site. Key mechanisms include axonal sprouting, synaptogenesis, dendritic remodeling, and brain‐derived neurotrophic factor signaling via TrkB receptors.
Ravi Kumar Rajan
wiley   +1 more source

Effects of obesity‐associated plasma markers on adipose stem cell function and epigenetic regulation

Obesity, EarlyView.
Abstract Objective This study investigates the correlations between obesity‐related plasma markers and epigenetic/inflammatory changes in white adipose tissue (WAT), focusing on adipose‐derived stem cells (ASCs). We hypothesize that obesity modulates histone H3K27 marks, modified by demethylases (lysine‐specific demethylase 6A and 6B [KDM6A/KDM6B]) and
Andressa França Sousa Bispo, Jussara de Jesus Simao, Miguel Ambrizzi Moraes, Ana Beatriz Marques Abel, Victor Tadeu Gonçalves Plata, Monica Marques Telles, André Valente Santana, Paula Volpe, Lucia Maria Armelin‐Correa, Maria Isabel Cardoso Alonso‐Vale   +9 more
wiley   +1 more source

Crystal Structure of Yeast Esa1 Suggests a Unified Mechanism for Catalysis and Substrate Binding by Histone Acetyltransferases [PDF]

, 2000
Yuan Yan, Nikolai A. Barlev, Rand Haley, Shelley L. Berger, Ronen Marmorstein   +4 more
openalex   +1 more source