Cancer stem cell quiescence is a regulated, reversible survival mechanism, preserving stemness and promoting therapy resistance through intrinsic programs and niche signals. Targeting these pathways holds promise for eradicating quiescent CSCs and preventing recurrence.
Yasin Ahmadi +3 more
wiley +1 more source
Catalytic-dependent and independent functions of the histone acetyltransferase CBP promote pioneer-factor-mediated zygotic genome activation. [PDF]
Marsh AJ +8 more
europepmc +1 more source
ABSTRACT Ferroptosis is a form of programmed cell death characterized by iron‐dependent phospholipid peroxidation and is implicated in a wide range of human diseases. Emerging evidence highlights the critical role of epigenetic regulation in this process.
Xiaoqian Tang +5 more
wiley +1 more source
Tissue-specific localization of the ING4 targeting subunit of the HBO1 histone acetyltransferase in the cytoplasm and nucleus of secretory cells. [PDF]
Dantas A +10 more
europepmc +1 more source
Mechanistic Pathways of Wound Healing: From Hemostasis to Scar‐Free Regeneration
ABSTRACT Wound healing is the critical process regulated through a harmonious coordination of cellular, molecular, pathological, and systemic communications. Normally, healing occurs in four overlapping phases, which are modified and controlled by various growth factor interactions and signaling pathways.
Devadass Jessy Mercy +2 more
wiley +1 more source
Histone acetyltransferase GCN5 orchestrates flower development and is required for proper regulation of multiple key meristem and organ identity genes. [PDF]
Wang J.
europepmc +1 more source
Proposed gut‐vascular framework linking microbial ecology to atherosclerotic disease. Diet and related exposures shape dysbiosis or microbial resilience; resulting changes in SCFAs, TMAO, bile acids, and LPS may modulate endothelial function, immune activation, and platelet activity, contributing to atherosclerosis, ACS, and PAD.
Amr Ali Mohamed Abdelgawwad El‐Sehrawy +7 more
wiley +1 more source
Histone Acetyltransferase MOF-Mediated AURKB K215 Acetylation Drives Breast Cancer Cell Proliferation via c-MYC Stabilization. [PDF]
Miao Y +9 more
europepmc +1 more source
Insights into ANKRD11‐related epilepsy from 163 people
Abstract Objective Ankyrin repeat domain 11 gene (ANKRD11) is the key disease gene for autosomal dominant KBG syndrome, and a subset of affected individuals develop epilepsy. However, comprehensive characterization of epilepsy‐related phenotypes and genotype–phenotype correlations in ANKRD11 variant carriers remains limited.
Song Su +6 more
wiley +1 more source
Design of a Bioluminescent Assay Platform for Quantitative Measurement of Histone Acetyltransferase Enzymatic Activity. [PDF]
Swain ND, George Zheng Y.
europepmc +1 more source

