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Mammalian histone acetyltransferases and their complexes
Cellular and Molecular Life Sciences, 2001One of the key questions in the current molecular genetics of eukaryotes is how genetic information is retrieved from tightly packed chromatin. Acetylation of core histone N-termini is implicated in the regulation of chromatin function, and I summarize what is known about the mammalian enzymes that promote this posttranslational histone modification ...
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Methods, 2003
Dynamic histone acetylation has a role in chromatin remodeling and in the regulation of transcription. Histone deacetylases (HDACs) and histone acetyltransferases (HATs) catalyze reversible histone acetylation. HATs and HDACs exist as multiprotein complexes that have coactivator and corepressor activities, respectively.
Jian-Min, Sun +4 more
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Dynamic histone acetylation has a role in chromatin remodeling and in the regulation of transcription. Histone deacetylases (HDACs) and histone acetyltransferases (HATs) catalyze reversible histone acetylation. HATs and HDACs exist as multiprotein complexes that have coactivator and corepressor activities, respectively.
Jian-Min, Sun +4 more
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Histone acetyltransferases and histone deacetylases of Physarum polycephalum
Cell Biology International Reports, 1992Abstract DEAE-Sepharose chromatography of plasmodial extracts of the myxomycete Physarum polycephalum reveals the presence of multiple histone acetyltransferases and histone deacetylases. Five putative histone acetyltransferases and histone deacetylases.
G BROSCH +5 more
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Histone acetyltransferases: function, structure, and catalysis
Current Opinion in Genetics & Development, 2001Histone acetyltransferases (HATs) directly link chromatin modification to gene activation. Recent structure/function studies provide insights into HAT catalysis and histone binding, and genetic studies suggest cross-talk between acetylation and other histone modifications.
R, Marmorstein, S Y, Roth
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The diverse functions of histone acetyltransferase complexes
Trends in Genetics, 2003Although histone acetylation has historically been linked to transcription activation, recent studies indicate that this modification and the enzymes that catalyze it have much broader and diverse functions. Histone acetyltransferase complexes are involved in such diverse processes as transcription activation, gene silencing, DNA repair and cell-cycle ...
Michael J, Carrozza +3 more
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Histone acetyltransferases in control.
Current biology : CB, 1997Several transcriptional regulators have been found to act as enzymes that acetylate histones. The targeted post-translational modification of histones within regulatory nucleoprotein complexes provides an attractive mechanism for controlling transcription within a chromatin environment.
P A, Wade, A P, Wolffe
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Recent insights intoHistone Acetyltransferase-1: biological function and involvement in pathogenesis
Epigenetics, 2021Angela Nebbioso +2 more
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