Results 231 to 240 of about 391,128 (337)

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, Volume 13, Issue 54, 28 September 2026.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia. [PDF]

Cancer Discov
Michmerhuizen NL, Heikamp EB, Iacobucci I, Umeda M, Arthur B, Mishra V, Park CS, Di Giacomo D, Hiltenbrand R, Gao Q, Radko-Juettner S, Lott J, Martucci C, Subramanyam V, Hatton C, Wenge DV, Baviskar P, Portola P, Claquin A, Chandra B, Baggett DW, Khalighifar A, Huang H, Zhou P, Long L, Shi H, Sun Y, Papachristou EK, Sekhar Reddy Chilamakuri C, de Luna Vitorino FN, Gongora JM, Wu H, Pounds SB, Janke LJ, Kentsis A, D'Santos CS, Garcia BA, Kriwacki RW, Chi H, Klco JM, Armstrong SA, Mullighan CG.   +41 more
europepmc   +1 more source

Long‐Term Follow Up of Two Patients With Variants in the Cluster 1031‐1159 of TRRAP Gene: Expanding the Phenotype of Developmental Delay With or Without Dysmorphic Facies and Autism

American Journal of Medical Genetics Part A, Volume 200, Issue 9, Page 2099-2105, September 2026.
ABSTRACT The transformation/transcription domain‐associated protein (TRRAP) gene encodes a large multidomain protein, a member of the phosphatidylinositol 3‐kinase‐related kinase (PIKK) family. TRRAP is a component of the histone acetyltransferase (HAT) complex, and it plays an important role in gene transcription, DNA repair, and cell‐cycle regulation.
Roseli Maria Zechi‐Ceide, Vinicius Contrucci Dantas Segarra, Siulan Vendramini‐Pittoli, Henrique Regonaschi Serigatto, Luiza Virmond, Heloisa Marcelina da Cunha Palhares, Fernanda Jehee, Ana Cristina Victorino Krepischi, Carla Rosenberg, Carlos Henrique Paiva Grangeiro, Nancy Mizue Kokitsu‐Nakata   +10 more
wiley   +1 more source

Growth phase diets diminish histone acetyltransferase Gcn5 function and shorten lifespan of Drosophila males. [PDF]

EMBO Rep
Mizutani S, Furuya K, Mure A, Takahashi Y, Mori A, Sakurai N, Suito T, Nagao K, Umeda M, Watanabe K, Hattori Y, Uemura T.   +11 more
europepmc   +1 more source

Quantum‐Level Influences on Enzyme Reactions and Their Ripple Effects on Biological Phenomena

Advanced Physics Research, Volume 5, Issue 9, September 2026.
Because living organisms are ultimately composed of atoms and molecules, quantum‐mechanical effects are expected to contribute to biological phenomena. Quantum biology seeks to elucidate life processes from a quantum‐mechanical perspective. This review discusses how quantum‐level effects, including quantum tunneling, may propagate from enzymatic proton‐
Takeshi Yasuda
wiley   +1 more source

<i>Arabidopsis</i> HOOKLESS1 acts as a histone acetyltransferase to promote cotyledon greening during seedling de-etiolation. [PDF]

Proc Natl Acad Sci U S A
Peng Y, Peng T, Chu Y, Yan W, Yao R, Wen X, Qiu Y, Wang M, Xiao Z, Zhang D, Chen X, Yin Z, Wang Y, Guo H.   +13 more
europepmc   +1 more source

Lactate Metabolism: Separating Correlation From Causation

BioEssays, Volume 48, Issue 9, September 2026.
Elevated lactate is often interpreted as the cause of pathology, when it more commonly reflects underlying metabolic state. This review separates correlation from causation and highlights how advances in technology have transformed our understanding of lactate biology. ABSTRACT Lactate is among the most frequently measured metabolites in physiology and
Bhavya Blaze, Ahmad A. Cluntun
wiley   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, Volume 4, Issue 3, September 2026.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Histone acetyltransferase HAF2 associates with pyruvate dehydrogenase complex to control H3K14ac and H3K23ac in ethylene response. [PDF]

Cell Rep
Chen CY, Shao Z, Wang G, Zhao B, Hardtke HA, Leong J, Zhou T, Zhang YJ, Qiao H.   +8 more
europepmc   +1 more source

KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer.

Cancer Research, 2015
Laia Simó-Riudalbas, Montserrat Pérez-Salvia, F. Setien, A. Villanueva, C. Moutinho, A. Martínez-Cardús, S. Moran, M. Berdasco, A. Gómez, E. Vidal, M. Soler, H. Heyn, A. Vaquero, C. de la Torre, S. Barceló-Batllori, A. Vidal, L. Roz, U. Pastorino, K. Szakszon, G. Borck, C. Moura, F. Carneiro, I. Zondervan, S. Savola, Reika Iwakawa, T. Kohno, J. Yokota, M. Esteller   +27 more
semanticscholar   +1 more source