Results 291 to 300 of about 35,141 (364)

A Novel EP300 Variant in an African American Girl With Global Developmental Delay and Leukemia

Molecular Genetics &Genomic Medicine, Volume 13, Issue 6, June 2025.
Pathogenic germline missense and in‐frame indel variants in exons 30 or 31 of the EP300 gene are associated with Menke–Hennekam syndrome‐2 (MKHK2). In somatic cells, EP300 variants have been reported in lymphoma, leukemia, and various solid tumors. We present an African American girl with global developmental delay, failure to thrive, microcephaly ...
Subit Barua, Vundavalli V. Murty, Alejandro Iglesias, Jun Liao   +3 more
wiley   +1 more source

The Roles of Epigenetics in the Interplay Between Beneficial Rhizobacteria and Plants

Modern Agriculture, Volume 3, Issue 1, June 2025.
The activity of PGPR in soil enhances the availability of nutrients and hormones secreted by these PGPRs, while nutrients acquired from PGPR‐enriched soil induce epigenetic modifications in plants. These altered epigenetic marks subsequently regulate plant gene expression patterns, including those involved in metabolite synthesis (such as root exudates)
Rui Zou, Zhihui Lu, Armin Djamei, Friedrich Kragler, Hon‐Ming Lam, Shoudong Zhang   +5 more
wiley   +1 more source

Dissecting the Molecular Roles of Histone Chaperones in Histone Acetylation by Type B Histone Acetyltransferases (HAT-B). [PDF]

J Biol Chem, 2015
Haigney A, Ricketts MD, Marmorstein R.
europepmc   +1 more source

Phase Separation: A New Dimension to Understanding Tumor Biology and Therapy

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Liquid–liquid phase separation (LLPS) facilitates the assembly of biomolecular condensates by leveraging weak multivalent interactions. The low‐complexity domains, foldable domains of proteins, and nucleic acids provide multivalent interaction sites among different molecules and contribute to the formation of condensates.
Xingwen Wang, Minqiao Lu, Yi Zhang, Jiangwen Ma, Ying Hu   +4 more
wiley   +1 more source

Lysine acetylation modulates s‐OPA1 GTPase activity and oligomerization in mitochondrial membrane remodeling

Protein Science, Volume 34, Issue 6, June 2025.
Abstract Mitochondrial dynamics are regulated by coordinated fission and fusion events that rely on key proteins and lipids organized spatially within the mitochondria. The dynamin‐related GTPase Optic Atrophy 1 (OPA1) is essential for inner mitochondrial membrane fusion and cristae structure maintenance.
Javaid Jabbar, Bakht Afroze, Naomi X. Y. Ling, Jonathan S. Oakhill, Isabelle Rouiller   +4 more
wiley   +1 more source

Evidence for an oncogenic modifier role for mutant histone acetyltransferases in diffuse large B-cell lymphoma. [PDF]

Leuk Lymphoma, 2016
Haery L, Mussakhan S, Waxman DJ, Gilmore TD.   +3 more
europepmc   +1 more source

Investigation of the mechanisms involved in the biocontrol activities of natural products from a marine soil bacterium against rice blast

Pest Management Science, Volume 81, Issue 6, Page 3122-3135, June 2025.
This study identified a Pseudomonas aeruginosa strain R64 from mangrove soil with broad‐spectrum antimicrobial activity and demonstrated the biocontrol effects of primary bioactive compounds from R64 in rice blast suppression. Abstract BACKGROUND Rice blast, caused by Pyricularia oryzae, is a devastating fungal disease threatening global rice ...
Liwang Fei, Rahila Hafeez, Junliang Zhang, Shiquan Fu, Ying Xu, Lingyun Hao   +5 more
wiley   +1 more source

Targeting KMT5C Suppresses Lung Cancer Progression and Enhances the Efficacy of Immunotherapy

Advanced Science, Volume 12, Issue 19, May 22, 2025.
This study reveals that KMT5C activates DNA damage repair to inhibit STING‐IRF3 pathway, downstream type I IFN signaling and CCL5 secretion, leading to the downregulation of CD8+ T cell infiltration and function in NSCLC, ultimately facilitating tumor progression.
Yunfeng Yuan, Qianyu Li, Guoquan Yan, Yifei Qian, Wenyun Guo, Songling Li, Fan Wang, Wanjing Shang, Zijun Zhu, Di Ge, Yanan Wang, Yanfeng Liu   +11 more
wiley   +1 more source

The Nuclear Receptor NR1B1/RARα Arrests the Differentiation of Anti‐Tumor Effector Cytotoxic T Cells

Advanced Science, Volume 12, Issue 17, May 8, 2025.
RARα is highly expressed by differentiated effector and exhausted T cells and exerts a negative effect on effector T cell differentiation and the associated trafficking receptor switch. Upregulated RARα levels decrease the nuclear histone acetylase (HAT) activity, and this suppresses the expression of key Teff transcription factor BATF and trafficking ...
Patrick Niekamp, Ryun Hee Kim, Adithyan Jayaraman, Nils Klement, Raymond Kostlan, Chang H. Kim   +5 more
wiley   +1 more source

Copy Number Gains of VPS72 Drive De Novo Lipogenesis and Hepatocarcinogenesis via ATF3/mTORC1/SREBP1 Axis

Advanced Science, Volume 12, Issue 20, May 29, 2025.
VPS72 overexpression activates mTORC1 signaling, subsequently promoting lipid synthesis and driving HCC progression. VPS72 modulates the epigenetic landscape of ATF3 promoter, such as H2A.Z acetylation reduction and DNA methylation increase, which results in ATF3 repression and subsequent activation of mTORC1.
Qinglin Zhang, Yunxing Huang, Yin Tong, Kenneth Tsz Chun Ng, Jiangwen Zhang   +4 more
wiley   +1 more source