Identification of small molecules inhibitors of GCN5 histone acetyltransferase activity
, 2006 Antonello Mai +8 more
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Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.ABSTRACT Purpose In mouse embryos derived from round spermatid injection (ROSI), low developmental potential due to abnormal histone modification is improved by histone deacetylase (HDAC) inhibitors. However, some studies suggest that the use of such inhibitors leads to the birth of hypomorphic offspring.
Seiji Watanabe +9 more
wiley +1 more source
The kinetoplastid kinetochore protein KKT23 acetyltransferase is a structural homolog of GCN5 that acetylates the histone H2A C-terminal tail [PDF]
Patryk Ludzia +6 more
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Potential 14‐3‐3 binding sites in sirtuins reveal extended phosphosite‐recognition modes
Acta Crystallographica Section F, Volume 82, Issue 1, Page 32-40, January 2026.Identification, binding measurements and structure determination of human sirtuin phosphopeptides in complex with human adapter protein 14‐3‐3σ reveal variations among tight binders and suggest extended binding modes.The adapter proteins of the 14‐3‐3 family modulate the activity and/or localization of their binding partners, which they capture if a ...
Michael Weyand +2 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 1, Page 24-39, January 2026.Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley +1 more source
Clinical Genetics, Volume 109, Issue 1, Page 181-187, January 2026.We report on the clinical characteristics of three new patients with pathogenic TRRAP variants expanding the syndrome's phenotype. In order to investigate the TRRAP potential involvement in skeletal development, osteoclastogenesis in Patient 1 was evaluated and TRRAP expression in osteoclasts and osteoblasts were analyzed.
Chiara Minotti +17 more
wiley +1 more source
Corrigendum to “Neuroprotective and antioxidant capability of RW20 peptide from histone acetyltransferases caused by oxidative stress-induced neurotoxicity in in vivo zebrafish larval model” [J. King Saud Univ. – Sci. 34(3) (2022) 101861] [PDF]
Nagaram Prabha +6 more
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Ovarian Aging: A Multifaceted Perspective on Mechanisms
Cell Proliferation, Volume 59, Issue 1, January 2026.A mechanistic network of ovarian aging, highlighting mitochondrial dysfunction as a central hub interconnected with genetic, metabolic, and inflammatory pathways.
Xiaoqing Zhang +9 more
wiley +1 more source
Ubiquitination dynamics in human tumour viruses: Viral infection, oncogenesis and antiviral therapy
The FEBS Journal, Volume 293, Issue 2, Page 325-347, January 2026.The ubiquitin system is essential for cellular homeostasis and regulates many processes. Viruses, including oncogenic ones, exploit or evade this system to survive and replicate. This review explores how human tumour viruses manipulate the ubiquitination system to complete their life cycle, evade immunity and promote cancer.
Oscar Trejo‐Cerro +2 more
wiley +1 more source
Dissecting the Molecular Roles of Histone Chaperones in Histone Acetylation by Type B Histone Acetyltransferases (HAT-B). [PDF]
J Biol Chem, 2015 Haigney A, Ricketts MD, Marmorstein R.
europepmc +1 more source