Results 301 to 310 of about 223,415 (361)

Catalytic-dependent and independent functions of the histone acetyltransferase CBP promote pioneer factor-mediated zygotic genome activation [PDF]

Audrey J. Marsh, S. A. Pirogov, Abby J. Ruffridge, Suresh Sajwan, Tyler J. Gibson, George Hunt, Yadwinder Kaur, Melissa M. Harrison, Mattias Mannervik   +8 more
openalex   +1 more source

AIRE's Complex Role Beyond Promiscuous Gene Expression

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Central tolerance, established in the thymus, ensures T cells are nonreactive to self‐antigens while maintaining a functional immune repertoire. Medullary thymic epithelial cells (mTECs) and thymic dendritic cells (DCs) play a crucial role in this mechanism by orchestrating the selection and deletion of autoreactive thymocytes, a process ...
Pärt Peterson
wiley   +1 more source

Trained Immunity and Cardiovascular Risk: An Immunological Perspective

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Systemic inflammation is a key driver of atherogenesis and its complications. While anti‐inflammatory therapies targeting pathways such as IL‐1β and IL‐6 have shown promise in established atherosclerotic cardiovascular disease (ASCVD), potential systemic effects raise concerns about immune suppression and infection, underscoring the need for ...
Katherine A. Boden, Jason Chai, Tafadzwa T. J. Kufazvinei, Robin P. Choudhury   +3 more
wiley   +1 more source

Comparative Investigation of Cytotoxic Effects of Structurally Diverse Small Molecules and In Silico Analysis of 1‐Acetyl‐4‐(4‐Hydroxyphenyl)piperazine

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT This study assessed the anticancer activity of boron‐containing and structurally diverse small molecules in 4T1 breast cancer and Caco‐2 colon adenocarcinoma cells. Initial screening showed that five boronic acids lacked significant cytotoxicity, underscoring the structural specificity required for boron‐mediated bioactivity.
Azmi Yerlikaya, Emrah Tümer, Mustafa Güzel   +2 more
wiley   +1 more source

Convergent Metabolic Pathways in MASH Therapeutics: An AMPK‐Centric Analysis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 2, January 2026.
ABSTRACT Metabolic dysfunction‐associated steatohepatitis (MASH) is a leading cause of liver‐related morbidity driven by systemic metabolic dysregulation. The recent approval of resmetirom and the clinical success of GLP‐1 receptor agonists have heralded a new era in MASH therapy, yet a convergent understanding of the complex mechanisms of these ...
Seungchan Choi, Jin‐Seok Jung, Yie‐sung Seo, Sungmin Song, Jeehye Ham, Hannah Chung, Yousef Ramadan, Kangchan Choi   +7 more
wiley   +1 more source

Histone Acetyltransferase Hat1 Drives Malignant Progression in Lower-Grade Glioma: Reshaping the Immune Microenvironment and Molecular Mechanisms

Zhou Sha, Zongye Zhang, Han Liu, Yanzheng Gao, Zhendong Liu   +4 more
openalex   +1 more source

The Enteric Nervous System as a Mediator of Microbiota‐Gut‐Brain Interactions in Parkinson's Disease

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Parkinson's disease (PD) is a neurodegenerative disorder that is increasingly recognized as a gut‐brain disorder, involving gut dysfunction before the onset of motor symptoms. While many studies have focused on changes in gut microbiota, inconsistent results highlight the limitations of viewing PD through a microbiota‐only lens.
Luisa Valdetaro, Maria Carolina Ricciardi, Patricia Pereira Almeida, Milena Barcza Stockler‐Pinto, Ana Lucia Tavares‐Gomes   +4 more
wiley   +1 more source

Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications

Journal of Pineal Research, Volume 78, Issue 1, January 2026.
ABSTRACT Gastrointestinal (GI) cancers remain a leading cause of global morbidity and mortality, necessitating novel therapeutic strategies. Melatonin (MEL), an indoleamine with pleiotropic biological activities, has emerged as a promising adjuvant in oncology due to its antiproliferative, proapoptotic, and antioxidant properties.
Maciej Gonciarz, Benita Wiatrak, Iga Lombard, Łukasz Konecki, Joanna Sarbinowska   +4 more
wiley   +1 more source

Seamless, modular binary vectors for plant cell and molecular biology

Plant Biotechnology Journal, Volume 24, Issue 1, Page 145-158, January 2026.
Summary In plants, genetic manipulations are commonly performed using Agrobacterium tumefaciens, a plant pathogen whose abilities as a ‘natural genetic engineer’ have been co‐opted for biotechnological applications. In the widely used binary vector systems, Agrobacterium already contains a plasmid with most of the genes needed for virulence and is ...
Rory Greenhalgh, Wilson Horner, Katherine A. Klimpel, Snigdha Chatterjee, M. Regina Scarpin, Jacob O. Brunkard   +5 more
wiley   +1 more source

Exploring KAT6 as a therapeutic target in breast cancer: epigenetic approaches for precision medicine. [PDF]

NPJ Breast Cancer
Roussel-Simonin C, Fernandez-Martinez A, Postel-Vinay S, Mosele F, Viansone A, Massard C, Mouren A, Vibert J, Pistilli B.   +8 more
europepmc   +1 more source