Results 301 to 310 of about 35,141 (364)

Yaf9, a Novel NuA4 Histone Acetyltransferase Subunit, Is Required for the Cellular Response to Spindle Stress in Yeast

, 2003
Ivan Le Masson, David Y. Yu, Kurt Jensen, Anne Chevalier, Régis Courbeyrette, Yves Boulard, M. Mitchell Smith, Carl Mann   +7 more
openalex   +1 more source

SWI/SNF recruitment to a DNA double-strand break by the NuA4 and Gcn5 histone acetyltransferases. [PDF]

DNA Repair (Amst), 2015
Bennett G, Peterson CL.
europepmc   +1 more source

UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling

Advanced Science, Volume 12, Issue 20, May 29, 2025.
Lactylation of UDP‐glucose dehydrogenase (UGDH) represses its enzymatic activity and causes glycosaminoglycans loss. In addition, UGDH lactylation facilitates its interaction with chromosome region maintenance 1 (CRM1) and promotes the nucleocytoplasmic transport.
Weiren Lan, Xueman Chen, Huai Yu, Jianzhao Ruan, Jingliang Kang, Xiaoyu Nie, Yumei Cao, Su'an Tang, Changhai Ding   +8 more
wiley   +1 more source

Tax Recruitment of CBP/p300, via the KIX Domain, Reveals a Potent Requirement for Acetyltransferase Activity That Is Chromatin Dependent and Histone Tail Independent

, 2003
Sara A. Georges, Holli A. Giebler, Philip A. Cole, Karolin Luger, Paul J. Laybourn, Jennifer K. Nyborg   +5 more
openalex   +1 more source

Analysis and Identification of Therapeutic Targets for Neuronal Regeneration After Ischemic Stroke

Brain and Behavior, Volume 15, Issue 5, May 2025.
In this study, we screened and analyzed targets associated with neuronal regeneration after ischemic stroke (IS), and detected the expression of corresponding genes in cellular models. Our findings suggest that EGR1 and NR4A1 may represent promising therapeutic targets of neuronal regeneration after IS.
Xiao‐Li Min, Li Guo, Zhenyu Wang, Lei Zhao, Chenglong Shi, Xiaoyong Liu, Zhen Wang, Fei‐Fei Shang, Jiaping Wang   +8 more
wiley   +1 more source

One additional histone deacetylase and 2 histone acetyltransferases are involved in cellular patterning of Arabidopsis root epidermis. [PDF]

Plant Signal Behav, 2016
Chen WQ, Li DX, Zhao F, Xu ZH, Bai SN.
europepmc   +1 more source

Chidamide, a Histone Deacetylase Inhibitor, Combined With R‐GemOx in Relapsed/Refractory Diffuse Large B‐Cell Lymphoma (TRUST): A Multicenter, Single‐Arm, Phase 2 Trial

Cancer Medicine, Volume 14, Issue 9, May 2025.
ABSTRACT Background Histone deacetylase (HDAC) inhibitors demonstrated a synergistic anti‐tumor effect with rituximab and chemotherapy in preclinical studies on diffuse large B‐cell lymphoma (DLBCL). This phase 2 trial aimed to evaluate the efficacy and safety of chidamide, an orally active HDAC inhibitor, plus the R‐GemOx regimen for relapsed ...
Qihua Zou, Yuchen Zhang, Hui Zhou, Yulin Lai, Yi Cao, Zhiming Li, Ning Su, Wenyu Li, Huiqiang Huang, Panpan Liu, Xu Ye, Yudan Wu, Huo Tan, Runhui Zheng, Bingyi Wu, Hui Yang, Liye Zhong, Yuhong Lu, Yang Liang, Peng Sun, Lirong Li, Yingxian Liu, Danling Dai, Yi Xia, Qingqing Cai   +24 more
wiley   +1 more source

Advances in the Study of Metabolic Reprogramming in Gastric Cancer

Cancer Medicine, Volume 14, Issue 10, May 2025.
ABSTRACT Background Gastric cancer is one of the most prevalent malignancies of the digestive system and is associated with a poor prognosis, particularly in advanced metastatic stages, where the 5‐year survival rate is significantly low. Methods Recent research has demonstrated that metabolic reprogramming—including alterations in glucose, lipid, and ...
Yu Rong, Yuanyin Teng, Xiaoying Zhou
wiley   +1 more source

USP22 promotes the proliferation and Sorafenib resistance of hepatocellular carcinoma cells via its deubiquitinase activity

Clinical and Translational Medicine, Volume 15, Issue 5, May 2025.
USP22 promotes the proliferation of hepatocellular carcinoma cells via deubiquitinating and stabilising cyclin‐dependent kinase CDK11B, and it inhibits Sorafenib‐induced ferroptosis by decreasing H2BK120ub occupancy at TFRC TSS downstream region. Abstract Background Hepatocellular carcinoma remains one of the most lethal cancers, characterized by poor ...
Xiaochen Wang, Yijie Su, Bei Lan, Xuanyuan Li, Bodi Zhang, Liang Zhang, Yingmei Wang, Chunze Zhang, Chenghao Xuan   +8 more
wiley   +1 more source

Regulation and Function of the Atypical IκBs—Bcl‐3, IκBNS, and IκBζ—in Lymphocytes and Autoimmunity

European Journal of Immunology, Volume 55, Issue 5, May 2025.
This review article summarizes the currently available information on the functions of atypical IκB proteins including Bcl‐3, IκBNS, and IκBζ, which have been studied mostly in mouse models. We focus on the regulation of these modulators of transcription, describe their role in lymphocyte differentiation, and their involvement in the development of ...
Tanja Kübelbeck, Nina Olivera Wichmann, Timsse Raj, Cynthia Raj, Caspar Ohnmacht, Nadine Hövelmeyer, Daniela Kramer, Vigo Heissmeyer   +7 more
wiley   +1 more source