Results 1 to 10 of about 351 (50)
Journal of Integrative Neuroscience, 2023 Neurodevelopment is a highly regulated process that relies on the precise regulation of gene expression. Numerous epigenetic mechanisms contribute and cooperate to ensure the proper execution of developmental gene expression programs.
Karanveer S Johal +2 more
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The Saccharomyces cerevisiae histone chaperone Rtt106 mediates the cell cycle recruitment of SWI/SNF and RSC to the HIR-dependent histone genes. [PDF]
PLoS ONE, 2011 In Saccharomyces cerevisiae, three out of the four histone gene pairs (HTA1-HTB1, HHT1-HHF1, and HHT2-HHF2) are regulated by the HIR co-repressor complex.
Monica E Ferreira +2 more
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Dynamic Activity of Histone H3-Specific Chaperone Complexes in Oncogenesis
Frontiers in Oncology, 2022 Canonical histone H3.1 and variant H3.3 deposit at different sites of the chromatin via distinct histone chaperones. Histone H3.1 relies on chaperone CAF-1 to mediate replication-dependent nucleosome assembly during S-phase, while H3.3 variant is ...
Ting Wen, Qiao Yi Chen
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The histone chaperone NASP maintains H3-H4 reservoirs in the early Drosophila embryo.
PLoS Genetics, 2023 Histones are essential for chromatin packaging, and histone supply must be tightly regulated as excess histones are toxic. To drive the rapid cell cycles of the early embryo, however, excess histones are maternally deposited.
Reyhaneh Tirgar +3 more
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FACT modulates the conformations of histone H2A and H2B N-terminal tails within nucleosomes
Communications Biology, 2022 NMR experiments reveal distinct interactions of the histone chaperone, FACT, with the proximal and distal flexible histone H2A and H2B tails of the asymmetrically unwrapped nucleosome.
Yasuo Tsunaka +2 more
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Advanced Science, 2023 Chromatin homeostasis mediates essential processes in eukaryotes, where histone chaperones have emerged as major regulatory factors during DNA replication, repair, and transcription.
Pedro Buzón +5 more
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Cell Reports, 2021 Summary: Heterochromatin formation requires three distinct steps: nucleation, self-propagation (spreading) along the chromosome, and faithful maintenance after each replication cycle.
Magdalena Murawska +7 more
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Histone chaperone ASF1 mediates H3.3-H4 deposition in Arabidopsis
Nature Communications, 2022 Histone chaperones and chromatin remodelers control nucleosome dynamics. Here the authors show that the Arabidopsis ASF1 chaperone primarily supplies histone variants to the HIRA complex to ensure proper epigenetic gene regulation.
Zhenhui Zhong +14 more
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Cell Reports, 2023 Summary: All vertebrate genomes encode for three large histone H2A variants that have an additional metabolite-binding globular macrodomain module, macroH2A. MacroH2A variants impact heterochromatin organization and transcription regulation and establish
Imke K. Mandemaker +9 more
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Cell Reports, 2020 Summary: HIRA is a histone chaperone that deposits the histone variant H3.3 in transcriptionally active genes. In DiGeorge syndromes, a DNA stretch encompassing HIRA is deleted.
Chao Chen +9 more
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