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H3–H4 histone chaperones and cancer
Current Opinion in Genetics & Development, 2022 Histone chaperones are key regulators of chromatin structure and function. Their frequent mis-regulation in various cancers can impact tumor initiation and progression. Here, we focus on H3-H4 histone chaperones to highlight recent studies concerning their roles in several cancers thereby expanding on previous reports illustrating their functions as ...
Ray-Gallet, Dominique +1 more
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Histone chaperone networks shaping chromatin function [PDF]
Nature Reviews Molecular Cell Biology, 2017 The association of histones with specific chaperone complexes is important for their folding, oligomerization, post-translational modification, nuclear import, stability, assembly and genomic localization. In this way, the chaperoning of soluble histones is a key determinant of histone availability and fate, which affects all chromosomal processes ...
Hammond, Colin +4 more
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Histone chaperones link histone nuclear import and chromatin assembly [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2012 Histone chaperones are proteins that shield histones from nonspecific interactions until they are assembled into chromatin. After their synthesis in the cytoplasm, histones are bound by different histone chaperones, subjected to a series of posttranslational modifications and imported into the nucleus.
Kristin M, Keck, Lucy F, Pemberton
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The histone shuffle: histone chaperones in an energetic dance [PDF]
Trends in Biochemical Sciences, 2010 Our genetic information is tightly packaged into a rather ingenious nucleoprotein complex called chromatin in a manner that enables it to be rapidly accessed during genomic processes. Formation of the nucleosome, which is the fundamental unit of chromatin, occurs via a stepwise process that is reversed to enable the disassembly of nucleosomes.
Chandrima, Das +2 more
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Histone acetylation-independent transcription stimulation by a histone chaperone [PDF]
Nucleic Acids Research, 2006 Histone chaperones are thought to be important for maintaining the physiological activity of histones; however, their exact roles are not fully understood. The physiological function of template activating factor (TAF)-I, one of the histone chaperones, also remains unclear; however, its biochemical properties have been well studied.
Kato, Kohsuke +3 more
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DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network [PDF]
Molecular Cell, 2021 From biosynthesis to assembly into nucleosomes, histones are handed through a cascade of histone chaperones, which shield histones from non-specific interactions. Whether mechanisms exist to safeguard the histone fold during histone chaperone handover events or to release trapped intermediates is unclear.
Hammond, Colin M. +13 more
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Histone Chaperones: Modulators of Chromatin Marks [PDF]
Molecular Cell, 2011 The many factors that control chromatin biology play key roles in essential nuclear functions like transcription, DNA damage response and repair, recombination, and replication and are critical for proper cell-cycle progression, stem cell renewal, differentiation, and development. These players belong to four broad classes: histone modifiers, chromatin
Avvakumov, Nikita +2 more
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Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast
Nature Communications, 2018 Dot1 is an evolutionarily conserved enzyme, responsible for histone H3K79 methylation in most eukaryotes. Here authors show that, in yeast, Dot1p has histone chaperone activity and regulates nucleosome dynamics via histone exchange in transcribed regions.
Soyun Lee +9 more
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The yeast histone chaperone hif1p functions with RNA in nucleosome assembly. [PDF]
PLoS ONE, 2014 Hif1p is an H3/H4-specific histone chaperone that associates with the nuclear form of the Hat1p/Hat2p complex (NuB4 complex) in the yeast Saccharomyces cerevisiae. While not capable of depositing histones onto DNA on its own, Hif1p can act in conjunction
Amy R Knapp, Huanyu Wang, Mark R Parthun
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The histone variant H3.3 regulates the transcription of the hepatitis B virus
Annals of Hepatology, 2021 Introduction and Objectives: About 250 million people around the world are chronically infected with the hepatitis B virus (HBV). Those people are at risk of developing hepatocellular carcinoma.
Francisca Alvarez-Astudillo +5 more
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