Results 31 to 40 of about 421 (119)
Histone chaperones, histone acetylation, and the fluidity of the chromogenome [PDF]
Journal of Cellular Physiology, 2010 AbstractThe “chromogenome” is defined as the structural and functional status of the genome at any given moment within a eukaryotic cell. This article focuses on recently uncovered relationships between histone chaperones, post‐translational acetylation of histones, and modulation of the chromogenome.
Jeffrey C, Hansen +3 more
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A Developmental Requirement for HIRA-Dependent H3.3 Deposition Revealed at Gastrulation in Xenopus
Cell Reports, 2012 Discovering how histone variants that mark distinct chromatin regions affect a developmental program is a major challenge in the epigenetics field. To assess the importance of the H3.3 histone variant and its dedicated histone chaperone HIRA, we used an ...
Emmanuelle Szenker +2 more
doaj +1 more source
The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis [PDF]
The EMBO Journal, 2013 Histone chaperones affect chromatin structure and gene expression through interaction with histones and RNA polymerase II (PolII). Here, we report that the histone chaperone Spt6 counteracts H3K27me3, an epigenetic mark deposited by the Polycomb Repressive Complex 2 (PRC2) and associated with transcriptional repression.
A Hongjun, Wang +8 more
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mBio, 2021 Histone chaperoning ensures genomic integrity during routine processes such as DNA replication and transcription as well as DNA repair upon damage. Here, we identify a nuclear J domain protein, Dnj4, in the fungal pathogen Cryptococcus neoformans and ...
Linda C. Horianopoulos +7 more
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Catalytic activation of histone acetyltransferase Rtt109 by a histone chaperone [PDF]
Proceedings of the National Academy of Sciences, 2010 Most histone acetyltransferases (HATs) function as multisubunit complexes in which accessory proteins regulate substrate specificity and catalytic efficiency. Rtt109 is a particularly interesting example of a HAT whose specificity and catalytic activity require association with either of two histone chaperones, Vps75 or Asf1.
Kolonko, Erin M. +8 more
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Histone Chaperones as Cardinal Players in Development
Frontiers in Cell and Developmental Biology, 2022 Dynamicity and flexibility of the chromatin landscape are critical for most of the DNA-dependent processes to occur. This higher-order packaging of the eukaryotic genome into the chromatin is mediated by histones and associated non-histone proteins that determine the states of chromatin.
Sruthy Manuraj Rajam +4 more
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eLife, 2022 A newly discovered pathway suggests histone proteins H3 and H4 are imported into the nucleus as individual units rather than joined together as heterodimers as was previously thought.
Hongyu Bao, Hongda Huang
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Chaperoning histones at the DNA repair dance
DNA Repair, 2021 Unlike all other biological molecules that are degraded and replaced if damaged, DNA must be repaired as chromosomes cannot be replaced. Indeed, DNA endures a wide variety of structural damage that need to be repaired accurately to maintain genomic stability and proper functioning of cells and to prevent mutation leading to disease.
Ujani Chakraborty +2 more
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Epigenetics & Chromatin, 2021 Background Asf1 is a well-conserved histone chaperone that regulates multiple cellular processes in different species. Two paralogous genes, Asf1a and Asf1b exist in mammals, but their role during fertilization and early embryogenesis remains to be ...
Xuemei Wang +7 more
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Chaperoning Histones during DNA Replication and Repair [PDF]
Cell, 2010 Nuclear DNA is tightly packaged into chromatin, which profoundly influences DNA replication, transcription, repair, and recombination. The extensive interactions between the basic histone proteins and acidic DNA make the nucleosomal unit of chromatin a highly stable entity. For the cellular machinery to access the DNA, the chromatin must be unwound and
Ransom, Monica +2 more
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