Results 41 to 50 of about 421 (119)
Placing the HIRA Histone Chaperone Complex in the Chromatin Landscape
Cell Reports, 2013 The HIRA chaperone complex, comprised of HIRA, UBN1, and CABIN1, collaborates with histone-binding protein ASF1a to incorporate histone variant H3.3 into chromatin in a DNA replication-independent manner.
Nikolay A. Pchelintsev +6 more
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New chaps in the histone chaperone arena [PDF]
Genes & Development, 2010 Understanding exactly how chromatin is assembled is paramount to addressing how select histone modifications may be transmitted, a putative epigenetic process. In the June 15, 2010, issue of Genes & Development, Drané and colleagues (pp. 1253–1265) identified DAXX as a novel H3.3-specific chaperone.
Eric I, Campos, Danny, Reinberg
openaire +2 more sources
Nature Communications, 2018 The HIRA histone chaperone complex is involved in the deposition of the histone variant H3.3. Here the authors, by using biochemical and crystallographic approaches, report the homotrimerization of the HIRA subunit which is critical for the functional ...
Dominique Ray-Gallet +7 more
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Cell Fate Decisions in the Wake of Histone H3 Deposition
Frontiers in Cell and Developmental Biology, 2021 An expanding repertoire of histone variants and specialized histone chaperone partners showcases the versatility of nucleosome assembly during different cellular processes. Recent research has suggested an integral role of nucleosome assembly pathways in
Reuben Franklin +2 more
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Structural basis underlying viral hijacking of a histone chaperone complex
Nature Communications, 2016 The Epstein-Barr virus tegument protein BNRF1 is required for the establishment of selective viral gene expression during latency and interacts with the histone chaperone DAXX.
Hongda Huang +6 more
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Epigenetics & Chromatin, 2021 Histone chaperones facilitate DNA replication and repair by promoting chromatin assembly, disassembly and histone exchange. Following histones synthesis and nucleosome assembly, the histones undergo posttranslational modification by different enzymes and
Yinjie Lian +5 more
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The histone chaperone function of Daxx is dispensable for embryonic development
Cell Death and Disease, 2023 Daxx functions as a histone chaperone for the histone H3 variant, H3.3, and is essential for embryonic development. Daxx interacts with Atrx to form a protein complex that deposits H3.3 into heterochromatic regions of the genome, including centromeres ...
Chang Sun +6 more
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A Role for FACT in RNA Polymerase II Promoter-Proximal Pausing
Cell Reports, 2019 Summary: FACT (facilitates chromatin transcription) is an evolutionarily conserved histone chaperone that was initially identified as an activity capable of promoting RNA polymerase II (Pol II) transcription through nucleosomes in vitro.
Theophilus T. Tettey +12 more
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HIRA stabilizes skeletal muscle lineage identity
Nature Communications, 2021 The epigenetic mechanisms coordinating the maintenance of adult cellular lineages remain poorly understood. Here the authors demonstrate that HIRA, a H3.3 histone chaperone, establishes the chromatin landscape required for skeletal muscle cell identity.
Joana Esteves de Lima +6 more
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Nature Communications, 2017 The histone chaperone nucleoplasmin (Npm) stores histones H2A/H2B in the egg and embryo. Here, the authors use NMR to show that Npm’s intrinsically disordered tail domain controls histone binding at an acidic stretch, which is autoregulated through ...
Christopher Warren +8 more
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