Results 121 to 130 of about 102,004 (245)

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

In vitro characterization of the catalytic domain of human histone deacetylase 5. [PDF]

Sci Rep
Mammen C, Hornung FM, Anzenhofer C, Schumacher J, Reiners J, Li J, Mazzone F, Bilsing FL, Kassack MU, Kurz T, Smits SHJ.   +10 more
europepmc   +1 more source

Automated analysis of postictal generalized electroencephalogram suppression for SUDEP risk stratification

Epilepsia Open, EarlyView.
Abstract Sudden unexpected death in epilepsy (SUDEP) affects more than 3000 individuals annually, yet objective and scalable biomarkers to assess risk remain limited. Postictal generalized electroencephalogram suppression (PGES) has been proposed as a potential biomarker, but its quantification is often subjective and variable.
Steve D. Reddy, Suprith Balasubramanian, Sreevidhya Ramakrishnan, Doodipala Samba Reddy   +3 more
wiley   +1 more source

Sialidosis type I: How to alleviate disabling myoclonic seizures?—A multicenter analysis of eight cases and review of the literature

Epilepsia Open, EarlyView.
Abstract Objective Sialidosis type I (ST‐1) is an autosomal‐recessive, very rare, progressive lysosomal storage disorder caused by pathogenic variants in NEU1. It is clinically characterized by progressive ataxia, myoclonic seizures (MS), bilateral tonic–clonic seizures (BTCS), and distinctive ophthalmological findings.
Janina Gburek‐Augustat, I‐Chun Lee, Marica Rubino, Vehap Topçu, Melissa Chavez‐Castillo, Shao Ching Tu, Marwan Shinawi, Isabel Alfradique‐Dunham, Manouela Valtcheva, Astrid Adarmes‐Gómez, Daniel Macias‐Garcia, Laura Laura Muñoz‐Delgado, Silvia Jesús, Pablo Mir, Andreas Merkenschlager, Antonietta Coppola   +15 more
wiley   +1 more source

Differential transcriptomic modulation by histone deacetylase inhibitor SAHA in LUAD and LUSC. [PDF]

Clin Epigenetics
Wang F, Yang Q, Shu L, Cen H, Huang Y, Ma X, Lin Y, Guan X, Wang C, Fu X, You G, Yu XY, Zhang L, Su J.   +13 more
europepmc   +1 more source

Resveratrol Ameliorates Allergic Rhinitis by Activating SIRT1 to Disrupt the Mitochondrial ROS‐Inflammation Vicious Cycle

Flavour and Fragrance Journal, EarlyView.
This study demonstrates that resveratrol alleviates allergic rhinitis by activating SIRT1, thereby disrupting the mitochondrial ROS‐inflammatory cycle, improving mitochondrial function, promoting anti‐inflammatory M2 macrophage polarisation, and reducing epithelial oxidative damage.
Xinyu Zhou, Yi Yue, Wenwen Qi, Wenqing Zhu, Xinran Liu, Rongcui Sui, Xuanchen Zhou   +6 more
wiley   +1 more source

Histone Deacetylase BpHST1 Regulates Plant Architecture and Photosynthesis in Birch. [PDF]

Biology (Basel)
Hou L, Li B, Ge M, Zheng Z.
europepmc   +1 more source

Imaging brain class I histone deacetylase changes in the Lewy body dementias and Parkinson's disease. [PDF]

Clin Epigenetics
Goodheart AE, Yoo CH, Fassini A, Dagnew TM, Ye R, Striar R, Quan M, Rattray AK, Meyer TN, Peterec E, Lee H, Fiedler SA, Hooker JM, Wey HY, Wang C, Gomperts SN.   +15 more
europepmc   +1 more source

Anti-tumor effect of a histone deacetylase inhibitor on canine malignant melanoma. [PDF]

J Vet Med Sci
Li T, Shibahara H, Kato D, Kodera Y, Ikeda N, Shinada M, Iguchi T, Shiyu Q, Ando M, Koseki S, Kako T, Motoi H, Hashimoto Y, Takahashi Y, Nishimura R, Nakagawa T.   +15 more
europepmc   +1 more source