Results 41 to 50 of about 155,197 (274)

Nuclear cGMP-dependent kinase regulates gene expression via activity-dependent recruitment of a conserved histone deacetylase complex. [PDF]

PLoS Genetics, 2011
Elevation of the second messenger cGMP by nitric oxide (NO) activates the cGMP-dependent protein kinase PKG, which is key in regulating cardiovascular, intestinal, and neuronal functions in mammals.
Yan Hao, Ningyi Xu, Andrew C Box, Laura Schaefer, Kasthuri Kannan, Ying Zhang, Laurence Florens, Christopher Seidel, Michael P Washburn, Winfried Wiegraebe, Ho Yi Mak   +10 more
doaj   +1 more source

Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases [PDF]

Molecular Pharmacology, 2011
This study investigates the mechanism by which histone deacetylase (HDAC) inhibitors up-regulate histone H3 lysine 4 (H3K4) methylation. Exposure of LNCaP prostate cancer cells and the prostate tissue of transgenic adenocarcinoma of the mouse prostate mice to the pan- and class I HDAC inhibitors (S)-(+)-N-hydroxy-4-(3-methyl-2-phenyl-butyrylamino ...
Po-Hsien, Huang, Chun-Han, Chen, Chih-Chien, Chou, Aaron M, Sargeant, Samuel K, Kulp, Che-Ming, Teng, John C, Byrd, Ching-Shih, Chen   +7 more
openaire   +2 more sources

Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors [PDF]

, 2010
Histone deacetylase inhibitors (HDI) dampen cellular innate immune response by decreasing interferon production and have been shown to increase the growth of vesicular stomatitis virus and HSV.
Atkins, H, Bell, JC, Breitbach, C, Cox, J, De Silva, N, Diallo, JS, Falls, T, Guimond, T, Huang, B, Kirn, D, Le Boeuf, F, MacTavish, H, McCart, AJ, Simmons, JG, Stanford, M, Thorne, S   +15 more
core   +1 more source

Epigenetic aberrations and cancer [PDF]

, 2006
The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms.
Brown, Mark A., Ducasse, Miryam
core   +3 more sources

Aberrant expression of histone deacetylases 4 in cognitive disorders: molecular mechanisms and a potential target

Frontiers in Molecular Neuroscience, 2016
Histone acetylation is a major mechanism of chromatin remodeling, contributing to epigenetic regulation of gene transcription. Histone deacetylases (HDACs) are involved in both physiological and pathological conditions by regulating the status of histone
Yili Wu, fei hou, xin wang, qingsheng kong, xiaolin han, bo bai   +5 more
doaj   +1 more source

Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy [PDF]

Kidney International, 2014
Studies have highlighted the importance of histone deacetylase (HDAC)-mediated epigenetic processes in the development of diabetic complications. Inhibitors of HDAC are a novel class of therapeutic agents in diabetic nephropathy, but currently available inhibitors are mostly nonselective inhibit multiple HDACs, and different HDACs serve very distinct ...
Xiaojie, Wang, Jiang, Liu, Junhui, Zhen, Chun, Zhang, Qiang, Wan, Guangyi, Liu, Xinbing, Wei, Yan, Zhang, Ziying, Wang, Huirong, Han, Huiyan, Xu, Chanchan, Bao, Zhenyu, Song, Xiumei, Zhang, Ningjun, Li, Fan, Yi   +15 more
openaire   +2 more sources

Rapamycin attenuates ioversol-induced acute kidney injury in rat models [PDF]

Jichu yixue yu linchuang
Objective To investigate the role of autophagy in contrast-induced acute kidney injury (CI-AKI) in rats and to explore its possible mechanism. Methods SD rats were randomly divided into control group, acute kidney injury model group (intravenous ...
LI Qingju, YU Ran, CHEN Jiajia, CHEN Haoyu, SONG Jian, WANG Wanpeng
doaj   +1 more source

Cyclic Equibiaxial Tensile Strain Alters Gene Expression of Chondrocytes via Histone Deacetylase 4 Shuttling. [PDF]

PLoS ONE, 2016
OBJECTIVES:This paper aims to investigate whether equibiaxial tensile strain alters chondrocyte gene expression via controlling subcellular localization of histone deacetylase 4 (HDAC4).
Chongwei Chen, Xiaochun Wei, Zhi Lv, Xiaojuan Sun, Shaowei Wang, Yang Zhang, Qiang Jiao, Xiaohu Wang, Yongping Li, Lei Wei   +9 more
doaj   +1 more source

Phosphatidylinositol 3‐Kinase–DNA Methyltransferase 1–miR‐1281–Histone Deacetylase 4 Regulatory Axis Mediates Platelet‐Derived Growth Factor–Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundPlatelet‐derived growth factor BB, a potent mitogen of pulmonary artery smooth muscle cells (PASMCs), has been implicated in pulmonary arterial remodeling, which is a key pathogenic feature of pulmonary arterial hypertension.
Yanjiao Li, Li Li, Zhengjiang Qian, Boya Lin, Jidong Chen, Yixuan Luo, Junle Qu, J. Usha Raj, Deming Gou   +8 more
doaj   +1 more source

Discovery of 2-Phenylquinoline-4-Carboxylic Acid Derivatives as Novel Histone Deacetylase Inhibitors

Frontiers in Chemistry, 2022
Inhibition of histone deacetylases (HDACs) has been extensively studied in the development of anticancer drugs. In the discovery of potent HDAC inhibitors with novel structures, the 2-substituted phenylquinoline-4-carboxylic acid group was introduced to ...
Qian Hui, Lihui Zhang, Jinhong Feng, Lei Zhang   +3 more
doaj   +1 more source