Results 21 to 30 of about 197,157 (312)

Small Molecule Inhibitors of KDM5 Histone Demethylases Increase the Radiosensitivity of Breast Cancer Cells Overexpressing JARID1B. [PDF]

Molecules, 2019
Background: KDM5 enzymes are H3K4 specific histone demethylases involved in transcriptional regulation and DNA repair. These proteins are overexpressed in different kinds of cancer, including breast, prostate and bladder carcinomas, with positive effects
Pippa S, Mannironi C, Licursi V, Bombardi L, Colotti G, Cundari E, Mollica A, Coluccia A, Naccarato V, La Regina G, Silvestri R, Negri R.   +11 more
europepmc   +2 more sources

The Clinically Used Iron Chelator Deferasirox is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases

ACS Chemical Biology, 2019
Fe(II)- and 2-oxoglutarate (2OG)-dependent JumonjiC domain-containing histone demethylases (JmjC KDMs) are epigenetic eraser enzymes involved in the regulation of gene expression and are emerging drug targets in oncology.
Manfred Jung, Martin Roatsch, Inga Hoffmann, Martine I. Abboud, Rebecca L. Hancock, Hanna Tarhonskaya, Kuo‐Feng Hsu, Sarah E. Wilkins, Tzu‐Lan Yeh, Kerstin Lippl, Kerstin Serrer, Isabelle Moneke, Theresa D. Ahrens, Dina Robaa, Sandra Wenzler, Henriette Franz, Wolfgang Sippl, Silke Laßmann, Sven Diederichs, Erik Schleicher, Christopher J. Schofield, Akane Kawamura, Roland Schüle   +22 more
openalex   +2 more sources

Crosstalk between epigenetics and metabolism-Yin and Yang of histone demethylases and methyltransferases in cancer. [PDF]

Brief Funct Genomics, 2017
Histone methylation is an epigenetic modification of chromatin undergoing dynamic changes and balancing tissue-specific demands of proliferation and differentiation.
Filipp FV.
europepmc   +2 more sources

Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy. [PDF]

Biomed Res Int, 2016
Epigenetic changes induced by histone demethylases play an important role in differentiation and pathological changes in cardiac cells. However, the role of the jumonji family of demethylases in the development of cardiac hypertrophy remains elusive.
Rosales W, Carulla J, García J, Vargas D, Lizcano F.   +4 more
europepmc   +2 more sources

Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox. [PDF]

Cancer Res, 2017
Yang J, Milasta S, Hu D, AlTahan AM, Interiano RB, Zhou J, Davidson J, Low J, Lin W, Bao J, Goh P, Nathwani AC, Wang R, Wang Y, Ong SS, Boyd VA, Young B, Das S, Shelat A, Wu Y, Li Z, Zheng JJ, Mishra A, Cheng Y, Qu C, Peng J, Green DR, White S, Guy RK, Chen T, Davidoff AM.   +30 more
europepmc   +2 more sources

H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization. [PDF]

, 2013
Histone lysine (K) methylation has been shown to play a fundamental role in modulating chromatin architecture and regulation of gene expression. Here we report on the identification of histone H3K56, located at the pivotal, nucleosome DNA entry/exit ...
Bussemer, Silva, Csankovszki, Gyorgyi, Hahn, Matthias, Hake, Sandra B., Jack, Antonia P. M., Pünzeler, Sebastian, Schotta, Gunnar, Snyder, Martha, Solovei, Irina, Wells, Michael   +9 more
core   +15 more sources

Inhibition of KDM7A/B histone demethylases restores H3K79 methylation and protects against osteoarthritis

Annals of the Rheumatic Diseases, 2023
Objectives In osteoarthritis, methylation of lysine 79 on histone H3 (H3K79me), a protective epigenetic mechanism, is reduced. Histone methylation levels are dynamically regulated by histone methyltransferases and demethylases. Here, we aimed to identify
Reem Assi, C. Cherifi, F. Cornelis, Qiongfei Zhou, L. Storms, S. Pazmino, Rodrigo Coutinho de Almeida, I. Meulenbelt, R. Lories, S. Monteagudo   +9 more
semanticscholar   +1 more source

Histone demethylases regulate adipocyte thermogenesis. [PDF]

Diabetol Int, 2018
Adipocytes play a pivotal role in the regulation of energy metabolism. While white adipocyte stores energy, brown adipocyte dissipates energy by producing heat. In addition, another type of heat-producing adipocyte, beige adipocyte, emerges in white adipose tissue in response to chronic coldness.
Inagaki T.
europepmc   +4 more sources

Relationship between histone demethylase LSD family and development and prognosis of gastric cancer

Frontiers in Immunology, 2023
Objectiveto elucidate the correlation between histone demethylase and gastric cancerResearch objecthistone demethylase and gastric cancerResultsAs one of the important regulatory mechanisms in molecular biology and epigenetics, histone modification plays
Liyan Dong, Jiaxing Zhu, Anyi Deng, Junping Wei, Jiawei Li, Xinru Mao, Zhenghu Jia, Zhenghu Jia, Zhenghu Jia   +8 more
doaj   +1 more source

Targeting histone demethylases as a potential cancer therapy (Review).

International Journal of Oncology, 2022
Post‑translational modifications of histones by histone demethylases have an important role in the regulation of gene transcription and are implicated in cancers.
Wenfei Diao, Jiabin Zheng, Yong Li, Junjiang Wang, Songhui Xu   +4 more
semanticscholar   +1 more source