Results 21 to 30 of about 18,790 (139)

JMJD family proteins in cancer and inflammation

Signal Transduction and Targeted Therapy, 2022
The occurrence of cancer entails a series of genetic mutations that favor uncontrollable tumor growth. It is believed that various factors collectively contribute to cancer, and there is no one single explanation for tumorigenesis.
Wang Manni, Xue Jianxin, Hong Weiqi, Chen Siyuan, Shi Huashan   +4 more
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Genome-wide gene expression profiling to investigate molecular phenotypes of Arabidopsis mutants deprived in distinct histone methyltransferases and demethylases

Genomics Data, 2015
Histone lysine (K) methylation is a type of epigenetic modification involved in regulation of DNA-based processes, including transcription, replication and repair.
Wei Zhao, Sarfraz Shafiq, Alexandre Berr, Wen-Hui Shen   +3 more
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The emerging roles for histone demethylases in the modulation of signaling pathways

Biomolecular Concepts, 2013
Since their discovery in 2004, histone demethylases have emerged as key regulators of chromatin. Recent studies have started to reveal the interconnections between histone demethylases and signaling pathways, suggesting that this interplay drives ...
Di Stefano Luisa, Dyson Nicholas J.
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The Histone H3K27me3 Demethylases KDM6A/B Resist Anoikis and Transcriptionally Regulate Stemness-Related Genes

Frontiers in Cell and Developmental Biology, 2022
Epithelial cancer cells that lose attachment from the extracellular matrix (ECM) to seed in a distant organ often undergo anoikis’s specialized form of apoptosis. Recently, KDM3A (H3K9 demethylase) has been identified as a critical effector of anoikis in
Mohammed Razeeth Shait Mohammed, Mohammed Razeeth Shait Mohammed, Mazin Zamzami, Hani Choudhry, Hani Choudhry, Firoz Ahmed, Firoz Ahmed, Bushra Ateeq, Mohammad Imran Khan, Mohammad Imran Khan   +9 more
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Disruption of Methionine Metabolism in Drosophila melanogaster Impacts Histone Methylation and Results in Loss of Viability

G3: Genes, Genomes, Genetics, 2016
Histone methylation levels, which are determined by the action of both histone demethylases and methyltransferases, impact multiple biological processes by affecting gene expression activity.
Mengying Liu, Valerie L. Barnes, Lori A. Pile   +2 more
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Discovery and structural studies of histone demethylases

Frontiers in Epigenetics and Epigenomics
The discovery and structural elucidation of histone demethylases represent a groundbreaking advancement in the field of epigenetics. Histone methylation, a critical chromatin modification, was long regarded as irreversible until the identification of ...
Longfei Peng, Xinze Li, Hao Yang, Haonan Chen, Yue Yang, Shunfeng Peng   +5 more
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Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.

PLoS ONE, 2010
BackgroundSmall molecule modulators of epigenetic processes are currently sought as basic probes for biochemical mechanisms, and as starting points for development of therapeutic agents.
Oliver N F King, Xuan Shirley Li, Masaaki Sakurai, Akane Kawamura, Nathan R Rose, Stanley S Ng, Amy M Quinn, Ganesha Rai, Bryan T Mott, Paul Beswick, Robert J Klose, Udo Oppermann, Ajit Jadhav, Tom D Heightman, David J Maloney, Christopher J Schofield, Anton Simeonov   +16 more
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Histone Demethylase Modulation: Epigenetic Strategy to Combat Cancer Progression

Epigenomes, 2023
Epigenetic modifications are heritable, reversible changes in histones or the DNA that control gene functions, being exogenous to the genomic sequence itself. Human diseases, particularly cancer, are frequently connected to epigenetic dysregulations. One
Rashmi Srivastava, Rubi Singh, Shaurya Jauhari, Niraj Lodhi, Rakesh Srivastava   +4 more
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Histone H4K20 Demethylation by Two hHR23 Proteins

Cell Reports, 2020
Summary: Histone methyl groups can be removed by demethylases. Although LSD1 and JmjC domain-containing proteins have been identified as histone demethylases, enzymes for many histone methylation states or sites are still unknown.
Xiongwen Cao, Yanran Chen, Bin Wu, Xiaoyun Wang, Hongjuan Xue, Lu Yu, Jie Li, Yiqin Wang, Wei Wang, Qing Xu, Hailei Mao, Chao Peng, Gang Han, Charlie Degui Chen   +13 more
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Epigenetic Control and Cancer: The Potential of Histone Demethylases as Therapeutic Targets

Pharmaceuticals, 2012
The development of cancer involves an immense number of factors at the molecular level. These factors are associated principally with alterations in the epigenetic mechanisms that regulate gene expression profiles.
Jeison Garcia, Fernando Lizcano
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