Results 31 to 40 of about 18,790 (139)

The histone demethylase Jhdm1a regulates hepatic gluconeogenesis. [PDF]

PLoS Genetics, 2012
Hepatic gluconeogenesis is required for maintaining blood glucose homeostasis; yet, in diabetes mellitus, this process is unrestrained and is a major contributor to fasting hyperglycemia.
Dongning Pan, Chunxiao Mao, Tie Zou, Annie Y Yao, Marcus P Cooper, Victor Boyartchuk, Yong-Xu Wang   +6 more
doaj   +1 more source

Function and Regulation of Histone H3 Lysine-4 Methylation During Oocyte Meiosis and Maternal-to-Zygotic Transition

Frontiers in Cell and Developmental Biology, 2020
During oogenesis and fertilization, histone lysine methyltransferases (KMTs) and histone lysine demethylases (KDMs) tightly regulate the methylation of histone H3 on lysine-4 (H3K4me) by adding and removing methyl groups, respectively.
Qian-Qian Sha, Jue Zhang, Heng-Yu Fan
doaj   +1 more source

Posttranslational modifications of the histone 3 tail and their impact on the activity of histone lysine demethylases in vitro. [PDF]

PLoS ONE, 2013
Posttranslational modifications (PTMs) of the histone H3 tail such as methylation, acetylation and phosphorylation play important roles in epigenetic signaling.
Brian Lohse, Charlotte Helgstrand, Jan B L Kristensen, Ulrike Leurs, Paul A C Cloos, Jesper L Kristensen, Rasmus P Clausen   +6 more
doaj   +1 more source

Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas

Nature Communications, 2021
Alternative Lengthening of Telomeres (ALT) is a telomere maintenance pathway utilised in 15% of cancers that have been associated with mutations in ATRX. Here the authors reveal a functional role of histone demethylases KDM4B in regulating ALT activation.
M. Udugama, L. Hii, A. Garvie, M. Cervini, B. Vinod, F.-L. Chan, P. P. Das, J. R. Mann, P. Collas, H. P. J. Voon, L. H. Wong   +10 more
doaj   +1 more source

Comprehensive Bioinformatics Analysis of Key Methyltransferases and Demethylases for Histone Lysines in Hepatocellular Carcinoma

Technology in Cancer Research & Treatment, 2020
Background & Aims: Methylation of lysines on histones, controlled by various methyltransferases and demethylases, is an important component of epigenetic modifications, and abnormal regulation of such enzymes serves as common events in hepatocellular ...
Yang Zheng PhD, Lili Tang, Guojiang Chen PhD, Ziling Liu PhD   +3 more
doaj   +1 more source

Lung Cancer Therapy Targeting Histone Methylation: Opportunities and Challenges

Computational and Structural Biotechnology Journal, 2018
Lung cancer is one of the most common malignancies. In spite of the progress made in past decades, further studies to improve current therapy for lung cancer are required.
Yuchen Chen, Xinran Liu, Yangkai Li, Chuntao Quan, Ling Zheng, Kun Huang   +5 more
doaj  

Reader domain specificity and lysine demethylase-4 family function

Nature Communications, 2016
KDM4 histone demethylases target specific chromatin regions by a mechanism that is not fully characterised. Here, the authors identify trimethyl-lysine histone-binding preferences for closely related KDM4 double tudor domains and use structural and ...
Zhangli Su, Fengbin Wang, Jin-Hee Lee, Kimberly E. Stephens, Romeo Papazyan, Ekaterina Voronina, Kimberly A. Krautkramer, Ana Raman, Jeremy J. Thorpe, Melissa D. Boersma, Vyacheslav I. Kuznetsov, Mitchell D. Miller, Sean D. Taverna, George N. Phillips, John M. Denu   +14 more
doaj   +1 more source

Contrasting epigenetic control of transgenes and endogenous genes promotes post-transcriptional transgene silencing in Arabidopsis

Nature Communications, 2021
Accumulating evidences point to a discrepancy in the epigenetic behaviour of transgenes and endogenous genes. Here, via characterization of mutants impaired in histone demethylases JMJ14 and IBM1, the authors show that transgenes and endogenous genes are
Nicolas Butel, Agnès Yu, Ivan Le Masson, Filipe Borges, Taline Elmayan, Christelle Taochy, Nial R. Gursanscky, Jiangling Cao, Shengnan Bi, Anne Sawyer, Bernard J. Carroll, Hervé Vaucheret   +11 more
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Protein complex interactor analysis and differential activity of KDM3 subfamily members towards H3K9 methylation.

PLoS ONE, 2013
Histone modifications play an important role in chromatin organization and gene regulation, and their interpretation is referred to as epigenetic control. The methylation levels of several lysine residues in histone tails are tightly controlled, and JmjC
Michael Brauchle, Zhiping Yao, Rishi Arora, Sachin Thigale, Ieuan Clay, Bruno Inverardi, Joy Fletcher, Paul Taslimi, Michael G Acker, Bertran Gerrits, Johannes Voshol, Andreas Bauer, Dirk Schübeler, Tewis Bouwmeester, Heinz Ruffner   +14 more
doaj   +1 more source

Elevated H3K27me3 levels sensitize osteosarcoma to cisplatin

Clinical Epigenetics, 2019
Background In osteosarcoma (OS), chemotherapy resistance has become one of the greatest issues leading to high mortality among patients. However, the mechanisms of drug resistance remain elusive, limiting therapeutic efficacy. Here, we set out to explore
Chao He, Jian Sun, Chao Liu, Yuhang Jiang, Yongqiang Hao   +4 more
doaj   +1 more source