Results 31 to 40 of about 197,157 (312)
Histone Lysine Demethylase Inhibitors [PDF]
Cold Spring Harbor Perspectives in Medicine, 2016 The dynamic regulation of covalent modifications to histones is essential for maintaining genomic integrity and cell identity and is often compromised in cancer. Aberrant expression of histone lysine demethylases has been documented in many types of blood and solid tumors, and thus demethylases represent promising therapeutic targets.
Ashwini, Jambhekar +2 more
openaire +2 more sources
Allele-Specific Inhibition of Histone Demethylases. [PDF]
Chembiochem, 2019 AbstractHistone demethylases play a critical role in mammalian gene expression by removing methyl groups from lysine residues in degree‐ and site‐specific manner. To specifically interrogate members and isoforms of this class of enzymes, we have developed demethylase variants with an expanded active site.
Wagner S +5 more
europepmc +4 more sources
Histone Demethylase LSD1 Regulates Adipogenesis [PDF]
Journal of Biological Chemistry, 2010 Epigenetic mechanisms, in particular the enzymatic modification of histones, are a crucial element of cell differentiation, a regulated process that allows a precursor cell basically to turn into a different cell type while maintaining the same genetic equipment.
Melina M, Musri +5 more
openaire +2 more sources
Histone Demethylases in Cancer [PDF]
Current Pharmacology Reports, 2015 Epigenetic regulation, which involves with covalent modifications of DNA and the protein that bundles DNA, namely histones, is an exciting and variable phenomenon that affects normal cellular genetic character and contributes to human diseases. One key histone modification is methylation, regulated by methyl transferases and demethylases.
Satheesh K. Sainathan +5 more
semanticscholar +3 more sources
Histone H4K20 Demethylation by Two hHR23 Proteins
Cell Reports, 2020 Summary: Histone methyl groups can be removed by demethylases. Although LSD1 and JmjC domain-containing proteins have been identified as histone demethylases, enzymes for many histone methylation states or sites are still unknown.
Xiongwen Cao +13 more
doaj +1 more source
Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization. [PDF]
PLoS ONE, 2012 Histone methylation regulates normal stem cell fate decisions through a coordinated interplay between histone methyltransferases and demethylases at lineage specific genes.
Chibawanye I Ene +18 more
doaj +1 more source
Biomolecules, 2021 Histone methylation tightly regulates chromatin accessibility, transcription, proliferation, and cell differentiation, and its perturbation contributes to oncogenic reprogramming of cells.
Hans Felix Staehle +2 more
doaj +1 more source
Current Perspectives on Histone Demethylases [PDF]
Acta Biochimica et Biophysica Sinica, 2007 The posttranslational modification of histones plays an important role in chromatin regulation. Histone methylation influences constitutive heterochromatin, genomic imprinting, X-chromosome inactivation and gene transcription. Histone demethylase catalyzes the removal of methyl groups on lysine or arginine residues of histones.
Xiaoqing, Tian, Jingyuan, Fang
openaire +2 more sources
Histone Demethylases in Colon Cancer [PDF]
Current Colorectal Cancer Reports, 2014 Cell growth and proliferation are controlled through different posttranslational modifications including demethylation, a process regulated by regulated by the demethylase enzymes. This review focuses on our current understanding of functional and therapeutic potentials of histone demethylases in colon cancer.
Santanu, Paul +5 more
openaire +2 more sources
Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature
Clinical Epigenetics, 2022 Histone 3 lysine 27 (H3K27) demethylation constitutes an important epigenetic mechanism of gene activation. It is mediated by the Jumonji C domain-containing lysine demethylases KDM6A and KDM6B, both of which have been implicated in a wide myriad of ...
J. Abu-Hanna +6 more
semanticscholar +1 more source