Results 81 to 90 of about 1,112,729 (199)

Epigenetic dynamics of Helicobacter pylori-induced COX-2 activation [PDF]

, 2009
Background and Aims: Cyclooxigenase (COX)-2 is over expressed in gastrointestinal neoplasia and Helicobacter pylori (H. pylori) infection is casually linked to gastric cancer. We undertook this study to investigate the mechanism mediating H.
Peluso, Silvia
core   +1 more source

P300 regulates histone crotonylation and preimplantation embryo development

Nature Communications
Histone lysine crotonylation, an evolutionarily conserved modification differing from acetylation, exerts pivotal control over diverse biological processes.
Di Gao, Chao Li, Shao-Yuan Liu, Teng-Teng Xu, Xiao-Ting Lin, Yong-Peng Tan, Fu-Min Gao, Li-Tao Yi, Jian V. Zhang, Jun-Yu Ma, Tie-Gang Meng, William S. B. Yeung, Kui Liu, Xiang-Hong Ou, Rui-Bao Su, Qing-Yuan Sun   +15 more
doaj   +1 more source

A role for SUMO modification in transcriptional repression and activation [PDF]

, 2007
Since the discovery of the SUMO (small ubiquitin-related modifier) family of proteins just over a decade ago, a plethora of substrates have been uncovered including many regulators of transcription.
Lyst, M J, Stancheva, I
core   +1 more source

Determination of enriched histone modifications in non-genic portions of the human genome

BMC Genomics, 2009
Background Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) has recently been used to identify the modification patterns for the methylation and acetylation of many different histone tails in genes and enhancers. Results We
Schones Dustin E, Wang Zhibin, Rosenfeld Jeffrey A, Zhao Keji, DeSalle Rob, Zhang Michael Q   +5 more
doaj   +1 more source

Lactate and lysine lactylation of histone regulate transcription in cancer

Heliyon
Histone lysine modifications were well-established epigenetic markers, with many types identified and extensively studied. The discovery of histone lysine lactylation had revealed a new form of epigenetic modification.
Yunhao Yang, Nanzhi Luo, Zhipeng Gong, Wenjing Zhou, Yin Ku, Yaohui Chen   +5 more
doaj   +1 more source

Down-regulation of the histone methyltransferase EZH2 contributes to the epigenetic programming of decidualizing human endometrial stromal cells [PDF]

, 2011
Differentiation of human endometrial stromal cells (HESC) into decidual cells represents a highly coordinated process essential for embryo implantation. We show that decidualizing HESC down-regulate the histone methyltransferase enhancer of Zeste homolog
Poutanen, Matti, Henriet, Patrick, Giulia Grimaldi, Poutanen, Matti,, Steel, Jennifer H., Steel, Jennifer H, Jan J. Brosens, Matti Poutanen, Brosens, Jan J., Christian, Mark, Brosens, Jan J, Mark Christian, Grimaldi, Giulia, Jennifer H. Steel, Patrick Henriet   +14 more
core   +1 more source

DNA methylation in chromatin - complexes and mechanisms [PDF]

, 2010
The DNA in the eukaryotic genome is packaged into chromatin whose basic repeating unit is the nucleosome consisting of 147bp of DNA wrapped around an octameric histone core.
Felle, Max
core   +1 more source

Molecular and clinical aspects of histone-related disorders

Human Genomics
Epigenetics is the coordination of gene expression without alterations in the DNA sequence. Epigenetic gene expression is regulated by an intricate system that revolves around the interaction of histone proteins and DNA within the chromatin structure ...
Mode Al Ojaimi, Bashar J. Banimortada, Abduljalil Alragheb, Razan S. Hajir, Carolina Alves, Duaa Walid, Afsheen Raza, Ayman W. El-Hattab   +7 more
doaj   +1 more source

TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells

Nature Communications, 2019
TRIM66 protein has an N-terminal tripartite motif and a C-terminal PHD Bromodomain. Here the authors show the specific histone modification recognition of TRIM66-PHD-Bromodomain through crystallography and biochemistry assay, and further reveal that ...
Jiajing Chen, Zikang Wang, Xudong Guo, Fudong Li, Qingtao Wei, Xuwen Chen, Deshun Gong, Yanxin Xu, Wen Chen, Yongrui Liu, Jiuhong Kang, Yunyu Shi   +11 more
doaj   +1 more source

Genome-wide analysis of histone acetylation dynamics during mouse embryonic stem cell neural differentiation

Genomics Data, 2015
Epigenetic modification as an intrinsic fine-tune program cooperates with key transcription factors to regulate the cell fate determination. The histone acetylation participating in neural differentiation of pluripotent stem cells is expected but not ...
Pingyu Liu, Xiaoyang Dou, Guangdun Peng, Jing-Dong Jackie Han, Naihe Jing   +4 more
doaj   +1 more source