Results 221 to 230 of about 2,005,250 (367)

Dynamics of activating and repressive histone modifications in Drosophila neural stem cell lineages and brain tumors [PDF]

, 2019
Merve Deniz Abdusselamoglu, Lisa Landskron, Sarah Bowman, Elif Eroğlu, Thomas R. Burkard, Robert E. Kingston, Juergen A. Knoblich   +6 more
openalex   +1 more source

Inactivation of AXL in Cardiac Fibroblasts Alleviates Right Ventricular Remodeling in Pulmonary Hypertension

Advanced Science, EarlyView.
Pulmonary hypertension (PH) is a progressive condition with high morbidity and mortality, largely owing to right ventricular (RV) failure resulting from maladaptive remodeling. Our study provides strong evidence in support of a critical, detrimental role for AXL as a previously unrecognized determinant driving RV fibrotic pathology in PH.
Li‐Wei Wu, Min Chen, Chen‐Yu Jiang, Dai‐Ji Jiang, Xu Zhang, Xiao‐He Xu, Yi‐Wei Liu, Bei Feng, Lin‐Cai Ye, Yang‐Yang He, Xu Huang, Yi‐Chi Zhang, Xing‐Liang Zhou, Yi Shen, Tian‐Yu Liu, Li‐Jun Fu, Yi Yan, Hao Zhang   +17 more
wiley   +1 more source

Parental benzo[a]pyrene exposure impacts histone modifications in osteoblast subpopulations. [PDF]

Environ Epigenet
Trujillo AS, Labeille RO, Jayarajan R, Mack D, Seemann F.   +4 more
europepmc   +1 more source

Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications

Proceedings of the National Academy of Sciences of the United States of America, 2017
Dana M. Hardbower, M. Asim, P. Luis, Kshipra Singh, D. Barry, Chunying Yang, Meredith A. Steeves, John L. Cleveland, C. Schneider, M. Piazuelo, A. Gobert, Keith T. Wilson   +11 more
semanticscholar   +1 more source

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

Advanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen, Xinhui Zheng, Jieliu Li, Minyu He, Dongqi Fan, Xingyu Zhu, Qiming Zhai, Liangjing Xin, Tao Chen   +8 more
wiley   +1 more source

Role of MNX1-mediated histone modifications and PBX gene family in MNX1-induced leukemogenesis. [PDF]

Sci Rep
Malmhäll-Bah E, Östlund A, Nilsson T, Weichenhan D, Bähr M, Hey J, Tunali G, Adamsson J, Jacobsson S, Fogelstrand L, Plass C, Palmqvist L, Waraky A.   +12 more
europepmc   +1 more source

Altered Histone Modifications in Gliomas [PDF]

, 2014
Young Zoon Kim
openalex   +1 more source

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

BAF250a Protein Regulates Nucleosome Occupancy and Histone Modifications in Priming Embryonic Stem Cell Differentiation [PDF]

, 2015
Ienglam Lei, Jason A. West, Zhijiang Yan, Xiaolin Gao, Fang Peng, Jonathan H. Dennis, Leonid Gnatovskiy, Weidong Wang, Robert E. Kingston, Zhong Wang   +9 more
openalex   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source