Results 241 to 250 of about 301,141 (302)

SIRT1 Prevents Ferroptosis in Corneal Epithelial Cells by Enhancing HIF1α Protein Stability in Dry Eye Disease

Advanced Science, EarlyView.
Hyperosmotic stress drives ferroptosis in corneal epithelium via SIRT1 downregulation. This work demonstrates that SIRT1 activation stabilizes HIF1α, which transcriptionally upregulates GPX4 to inhibit lipid peroxidation and cell death. The identified SIRT1/HIF1α/GPX4 axis reveals a novel defense mechanism and potential therapy for dry eye disease ...
Lili Lian, Zhenmin Le, Xuanqiao Ye, Zimo Wang, Jiuxiao Li, Chenyu Dong, Yetao Shen, Jiazheng Li, Yueping Ren, Xiaoyin Ma, Wei Chen, Qinxiang Zheng   +11 more
wiley   +1 more source

Single-cell multi-omic detection of DNA methylation and histone modifications reconstructs the dynamics of epigenomic maintenance. [PDF]

Nat Methods
Geisenberger C, van den Berg J, van Batenburg V, de Barbanson B, Lyubimova A, Verity-Legg J, Chen X, Liu Y, Song CX, de Ridder J, van Oudenaarden A.   +10 more
europepmc   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

A comprehensive review of histone modifications during mammalian oogenesis and early embryo development. [PDF]

Histochem Cell Biol
Bozdemir N, Kablan T, Biyikli E, Cinar O, Uysal F.   +4 more
europepmc   +1 more source

Epigenetic regulation by DNA methylation, histone modifications and chromatin remodeling complexes in controlling spermatogenesis and their dysfunction with male infertility. [PDF]

Cell Mol Life Sci
Cui Y, Deng J, Zhang Y, Du L, Jiang F, Li C, Chen W, Zhang H, He Z.   +8 more
europepmc   +1 more source

Integrative analysis of gene expression and histone modifications for DES, DSP, GJA1 and SMOC2 in adipose tissue reveals potential relationship to cardiometabolic health. [PDF]

Mol Med
Saeed S, Hoffmann A, Svensson SIA, Visnovska T, Hagemann T, Ghosh A, Wolfrum C, Cayir A, Mala T, Kristinsson JA, Blüher M, Valderhaug TG, Böttcher Y.   +12 more
europepmc   +1 more source

Dynamic metabolic regulation of histone modifications during the yeast metabolic cycle. [PDF]

PLoS One
Guzmán-Dinamarca B, Conejeros R, Rivas-Astroza M.   +2 more
europepmc   +1 more source

Epigenetic insights into prostate cancer: exploring histone modifications and their therapeutic implications. [PDF]

Front Oncol
Sharma B, Shekhar H, Sahu A, Kaur D, Haque S, Tuli HS, Sharma H, Sharma U.   +7 more
europepmc   +1 more source

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Histones and Their Modification

Critical Reviews in Biochemistry, 1986
Histones constitute the protein core around which DNA is coiled to form the basic structural unit of the chromosome known as the nucleosome. Because of the large amount of new histone needed during chromosome replication, the synthesis of histone and DNA is regulated in a complex manner.
R S, Wu, H T, Panusz, C L, Hatch, W M, Bonner   +3 more
openaire   +2 more sources

Histone Variants and Histone Modifications in Neurogenesis

Trends in Cell Biology, 2020
During embryonic brain development, neurogenesis requires the orchestration of gene expression to regulate neural stem cell (NSC) fate specification. Epigenetic regulation with specific emphasis on the modes of histone variants and histone post-translational modifications are involved in interactive gene regulation of central nervous system (CNS ...
Mengtian Zhang, Jinyue Zhao, Yuqing Lv, Wenwen Wang, Chao Feng, Wenzheng Zou, Libo Su, Jianwei Jiao   +7 more
openaire   +2 more sources