Results 221 to 230 of about 198,744 (258)
Some of the next articles are maybe not open access.
The language of covalent histone modifications
Nature, 2000Histone proteins and the nucleosomes they form with DNA are the fundamental building blocks of eukaryotic chromatin. A diverse array of post-translational modifications that often occur on tail domains of these proteins has been well documented. Although the function of these highly conserved modifications has remained elusive, converging biochemical ...
B D, Strahl, C D, Allis
openaire +2 more sources
Bivalent Histone Modifications and Development
Current Stem Cell Research & Therapy, 2018Development is an epigenetic regulation dependent event. As one pretranscriptional regulator, bivalent histone modifications were observed to be involved in development recently. It is believed that histone methylation potentially takes charge of cell fate determination and differentiation.
Feifei, Li +9 more
openaire +2 more sources
Histone interactions, histone modifications and chromatin structure
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1978Abstract A subunit structure for chromatin is now well established (Hewish & Burgoyne 1973; Burgoyne, Hewish & Hobbs 1974; Olins & Olins 1973, 1974; Woodcock 1973; Rill & Van Holde 1973; Kornberg 1974; Baldwin, Boseley, Bradbury & Ibel 1975; Oudet, Gross-Bellard & Chambon 1975)* Nuclease digestion of chromatin ...
openaire +2 more sources
Histone modifications and exercise adaptations
Journal of Applied Physiology, 2011The spatial association between genomic DNA and histone proteins within chromatin plays a key role in the regulation of gene expression and is largely governed by post-translational modifications to histone proteins, particularly H3 and H4. These modifications include phosphorylation, acetylation, and mono-, di-, and tri-methylation, and while some ...
Sean L, McGee, Mark, Hargreaves
openaire +2 more sources
Histone Modifications in Corepressor Functions
2004Publisher Summary This chapter emphasizes histone modifications in corepressor functions. Histone modifications play a regulatory role in gene expression by altering higher order chromatin structures and by providing docking sites for non-histone regulatory proteins. Many corepressor complexes contain or recruit histone-modifying activities.
Judith K, Davie, Sharon Y R, Dent
openaire +2 more sources
Global patterns of histone modifications
Current Opinion in Genetics & Development, 2007Histones, the proteins that package eukaryotic genomes into chromatin, are subject to a huge number and variety of covalent modifications. In the past few years, genomic technologies such as microarray hybridization have been applied to the study of histone modifications. These studies shed significant light on the role of covalent modifications in DNA-
openaire +2 more sources
Histone post-translational modifications — cause and consequence of genome function
Nature Reviews Genetics, 2022Robert Schneider +2 more
exaly