Role of Histone Post-Translational Modifications in Inflammatory Diseases [PDF]
Frontiers in Immunology, 2022 Inflammation is a defensive reaction for external stimuli to the human body and generally accompanied by immune responses, which is associated with multiple diseases such as atherosclerosis, type 2 diabetes, Alzheimer’s disease, psoriasis, asthma ...
Yingying Lin +15 more
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Mass spectrometry-based profiling of single-cell histone post-translational modifications to dissect chromatin heterogeneity [PDF]
Nature CommunicationsSingle-cell proteomics confidently quantifies cellular heterogeneity, however quantification of post-translational modifications, such as those deposited on histone proteins, remains elusive.
Ronald Cutler +11 more
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Histone post-translational modifications of Leishmania braziliensis [PDF]
Scientific DataHistone post-translational modifications (hPTMs) constitute an epigenetic mechanism that plays a fundamental role in the regulation of gene expression in eukaryotic cells. In trypanosomatid parasites, such as Trypanosoma brucei, T.
Rafael Fogaça de Almeida +3 more
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Role of histone post-translational modifications in atherosclerosis and the therapeutic potential of targeting epigenetic modifiers [PDF]
Frontiers in Cell and Developmental BiologyCardiovascular disease (CVD) remains the leading cause of mortality worldwide, with atherosclerosis being the primary pathological substrate underlying most CVD.
Lili Wu, Wei Li, Wei Ye
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An updated map of Trypanosoma cruzi histone post-translational modifications [PDF]
Scientific Data, 2021 Measurement(s) histone_modification Technology Type(s) mass spectrometry • nanoflow liquid chromatography-tandem mass spectrometry • Data-Dependent Acquisition Sample Characteristic - Organism Trypanosoma cruzi Machine-accessible metadata file describing
Rafael Fogaça de Almeida +2 more
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Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications [PDF]
Epigenetics, 2021 Post-translational modifications (PTMs) to the tails of the core histone proteins are critically involved in epigenetic regulation. Hypoxia affects histone modifications by altering the activities of histone-modifying enzymes and the levels of hypoxia ...
Kuo-Feng Hsu +8 more
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The Role of Histone Post-Translational Modifications in Merkel Cell Carcinoma [PDF]
Frontiers in Oncology, 2022 Merkel Cell Carcinoma (MCC) is a rare but highly aggressive form of non–melanoma skin cancer whose 5-year survival rate is 63%. Merkel cell polyomavirus (MCPyV), a small DNA tumor virus, is the etiological agent of MCC.
Chiara Mazziotta +11 more
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Novel histone post-translational modifications in Alzheimer’s disease: current advances and implications [PDF]
Clinical EpigeneticsAlzheimer’s disease (AD) has a complex pathogenesis, and multiple studies have indicated that histone post-translational modifications, especially acetylation, play a significant role in it.
Yuanyuan Qin +9 more
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DNA methylation and histone post-translational modifications in atherosclerosis and a novel perspective for epigenetic therapy [PDF]
Cell Communication and Signaling, 2023 Atherosclerosis, which is a vascular pathology characterized by inflammation and plaque build-up within arterial vessel walls, acts as the important cause of most cardiovascular diseases. Except for a lipid-depository and chronic inflammatory, increasing
Liang Zhang +7 more
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The role of histone post-translational modifications in cancer and cancer immunity: functions, mechanisms and therapeutic implications [PDF]
Frontiers in ImmunologyHistones play crucial roles in both promoting and repressing gene expression, primarily regulated through post-translational modifications (PTMs) at specific amino acid residues.
Xiaohong Duan +13 more
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