Proteomic interrogation of human chromatin. [PDF]
Chromatin proteins provide a scaffold for DNA packaging and a basis for epigenetic regulation and genomic maintenance. Despite understanding its functional roles, mapping the chromatin proteome (i.e. the "Chromatome") is still a continuing process. Here,
LeRoy, Gary +22 more
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Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome. [PDF]
Vertebrate embryos are derived from a transitory pool of pluripotent cells. By the process of embryonic induction, these precursor cells are assigned to specific fates and differentiation programs.
Jose M. Arteaga-Salas +16 more
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Histone H1 Post-Translational Modifications: Update and Future Perspectives [PDF]
Histone H1 is the most variable histone and its role at the epigenetic level is less characterized than that of core histones. In vertebrates, H1 is a multigene family, which can encode up to 11 subtypes.
Suau, Pedro +9 more
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Complex exon-intron marking by histone modifications is not determined solely by nucleosome distribution [PDF]
It has recently been shown that nucleosome distribution, histone modifications and RNA polymerase II (Pol II) occupancy show preferential association with exons (“exon-intron marking”), linking chromatin structure and function to co-transcriptional ...
Ellis Peter +75 more
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H3 Lysine 4 Is Acetylated at Active Gene Promoters and Is Regulated by H3 Lysine 4 Methylation [PDF]
Methylation of histone H3 lysine 4 (H3K4me) is an evolutionarily conserved modification whose role in the regulation of gene expression has been extensively studied.
Richard J. Festenstein +31 more
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Histone modifications influence the action of Snf2 family remodelling enzymes by different mechanisms [PDF]
Alteration of chromatin structure by chromatin modifying and remodelling activities is a key stage in the regulation of many nuclear processes. These activities are frequently interlinked, and many chromatin remodelling enzymes contain motifs that ...
Owen-Hughes, Tom; id_orcid +3 more
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How HP1 Post-Translational Modifications Regulate Heterochromatin Formation and Maintenance
Heterochromatin Protein 1 (HP1) is a highly conserved protein that has been used as a classic marker for heterochromatin. HP1 binds to di- and tri-methylated histone H3K9 and regulates heterochromatin formation, functions and structure.
Raquel Sales-Gil, Paola Vagnarelli
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Tau Stabilizes Chromatin Compaction
An extensive body of literature suggested a possible role of the microtubule-associated protein Tau in chromatin functions and/or organization in neuronal, non-neuronal, and cancer cells. How Tau functions in these processes remains elusive.
Thomas Rico +11 more
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Histone modifications and the HtrA-like serine protease Nma111p regulate apoptosis in budding yeast [PDF]
Histone modifications and the HtrA-like serine protease Nma111p regulate apoptosis in budding yeast David Walter, 2010, PhD Thesis, University of Basel Apoptosis is a form of programmed cell death that plays a central role in development and ...
Walter, David
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As a primary cause of death in patients with hematological malignancies and transplant recipients, invasive aspergillosis (IA) is a condition that warrants attention.
Yiman Li +7 more
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