Results 31 to 40 of about 130,653 (144)
Frontiers in Microbiology, 2022 As a primary cause of death in patients with hematological malignancies and transplant recipients, invasive aspergillosis (IA) is a condition that warrants attention.
Yiman Li +7 more
doaj +1 more source
Nuclear processes associated with plant immunity and pathogen susceptibility [PDF]
, 2015 Plants are sessile organisms that have evolved exquisite and sophisticated mechanisms to adapt to their biotic and abiotic environment. Plants deploy receptors and vast signalling networks to detect, transmit and respond to a given biotic threat by ...
Huitema, Edgar +3 more
core +3 more sources
Histone Mutants Separate R Loop Formation from Genome Instability Induction [PDF]
, 2017 R loops have positive physiological roles, but they can also be deleterious by causing genome instability, and the mechanisms for this are unknown. Here we identified yeast histone H3 and H4 mutations that facilitate R loops but do not cause instability.
Aguilera López, Andrés +5 more
core +1 more source
Non-mammalian model organisms in epigenetic research : an overview [PDF]
, 2020 Recent advances in sequencing technology and genome editing tools had an indisputably enormous impact on our understanding of complex biological pathways and their genetic and epigenetic regulation.
Baruah, Sri Kartik +3 more
core +2 more sources
Characterization of histone acylations links chromatin modifications with metabolism
Nature Communications, 2017 A number of histone lysine modifications related to acetylation have been identified, but their functional significance is unclear. Here, the authors use in vitro and in vivo assays to characterize eight acyl histone post-translational modifications and ...
Johayra Simithy +13 more
doaj +1 more source
GastroenterologìaBased on the analysis of literary sources of PubMed, MedLine, The Cochrane Library, EMBASE database, the authors of the article give general provisions regarding post-translational modifications of histones (small proteins with a molecular weight of 10 ...
O.E. Abaturov, A.O. Nikulina
doaj +1 more source
Multiplex giant magnetoresistive biosensor microarrays identify interferon-associated autoantibodies in systemic lupus erythematosus. [PDF]
, 2016 High titer, class-switched autoantibodies are a hallmark of systemic lupus erythematosus (SLE). Dysregulation of the interferon (IFN) pathway is observed in individuals with active SLE, although the association of specific autoantibodies with chemokine ...
Baechler, Emily C +10 more
core +2 more sources
Histone H2A variants play a key role at DNA double-strand breaks during repair pathway choice
Frontiers in Epigenetics and EpigenomicsHistone post-translational modifications and variants play crucial roles in the adaptability of chromatin structure, facilitating rapid responses necessary for biological processes such as transcription, replication, and DNA damage signaling.
Emile Clerf +3 more
doaj +1 more source
Nature Communications, 2018 Histone post-translational modifications are known key regulators of gene expression. Here, the authors characterize histone crotonylation at histone H3 lysine 18 in intestinal epithelia and find that it is a highly dynamic cell cycle regulated mark ...
Rachel Fellows +25 more
doaj +1 more source
Histone Modifications and the Maintenance of Telomere Integrity
Cells, 2019 Telomeres, the nucleoprotein structures at the ends of eukaryotic chromosomes, play an integral role in protecting linear DNA from degradation. Dysregulation of telomeres can result in genomic instability and has been implicated in increased rates of ...
Meagan Jezek, Erin M. Green
doaj +1 more source