Results 31 to 40 of about 5,681,501 (240)

Characterization of histone acylations links chromatin modifications with metabolism

Nature Communications, 2017
A number of histone lysine modifications related to acetylation have been identified, but their functional significance is unclear. Here, the authors use in vitro and in vivo assays to characterize eight acyl histone post-translational modifications and ...
Johayra Simithy, Simone Sidoli, Zuo-Fei Yuan, Mariel Coradin, Natarajan V. Bhanu, Dylan M. Marchione, Brianna J. Klein, Gleb A. Bazilevsky, Cheryl E. McCullough, Robert S. Magin, Tatiana G. Kutateladze, Nathaniel W. Snyder, Ronen Marmorstein, Benjamin A. Garcia   +13 more
doaj   +1 more source

Post-translational histone modifications associated with the development of metabolic dysfunction-associated fatty liver disease. Part 1. General provisions

Gastroenterologìa
Based on the analysis of literary sources of PubMed, MedLine, The Cochrane Library, EMBASE database, the authors of the article give general provisions regarding post-translational modifications of histones (small proteins with a molecular weight of 10 ...
O.E. Abaturov, A.O. Nikulina
doaj   +1 more source

Epigenetic dynamics of Helicobacter pylori-induced COX-2 activation [PDF]

, 2009
Background and Aims: Cyclooxigenase (COX)-2 is over expressed in gastrointestinal neoplasia and Helicobacter pylori (H. pylori) infection is casually linked to gastric cancer. We undertook this study to investigate the mechanism mediating H.
Peluso, Silvia
core   +1 more source

Histone H2A variants play a key role at DNA double-strand breaks during repair pathway choice

Frontiers in Epigenetics and Epigenomics
Histone post-translational modifications and variants play crucial roles in the adaptability of chromatin structure, facilitating rapid responses necessary for biological processes such as transcription, replication, and DNA damage signaling.
Emile Clerf, Maxime Galloy, Amélie Fradet-Turcotte, Jacques Côté   +3 more
doaj   +1 more source

Histone Modifications and the Maintenance of Telomere Integrity

Cells, 2019
Telomeres, the nucleoprotein structures at the ends of eukaryotic chromosomes, play an integral role in protecting linear DNA from degradation. Dysregulation of telomeres can result in genomic instability and has been implicated in increased rates of ...
Meagan Jezek, Erin M. Green
doaj   +1 more source

H2B Type 1-K Accumulates in Senescent Fibroblasts with Persistent DNA Damage along with Methylated and Phosphorylated Forms of HMGA1

Proteomes, 2021
Cellular senescence is a state of terminal proliferative arrest that plays key roles in aging by preventing stem cell renewal and by inducing the expression of a series of inflammatory factors including many secreted proteins with paracrine effects.
Kévin Contrepois, Carl Mann, François Fenaille   +2 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

An RNAi-based platform for spatiotemporal control of histone gene expression during animal development

Epigenetics & Chromatin
Background Mutational analysis of histones provides an important means of studying the function of histone post-translational modifications (PTMs) in epigenetic gene regulation.
Oscar M. Arroyo, Mary P. Leatham-Jensen, Daniel J. McKay   +2 more
doaj   +1 more source

Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

Nature Communications, 2018
Histone post-translational modifications are known key regulators of gene expression. Here, the authors characterize histone crotonylation at histone H3 lysine 18 in intestinal epithelia and find that it is a highly dynamic cell cycle regulated mark ...
Rachel Fellows, Jérémy Denizot, Claudia Stellato, Alessandro Cuomo, Payal Jain, Elena Stoyanova, Szabina Balázsi, Zoltán Hajnády, Anke Liebert, Juri Kazakevych, Hector Blackburn, Renan Oliveira Corrêa, José Luís Fachi, Fabio Takeo Sato, Willian R. Ribeiro, Caroline Marcantonio Ferreira, Hélène Perée, Mariangela Spagnuolo, Raphaël Mattiuz, Csaba Matolcsi, Joana Guedes, Jonathan Clark, Marc Veldhoen, Tiziana Bonaldi, Marco Aurélio Ramirez Vinolo, Patrick Varga-Weisz   +25 more
doaj   +1 more source

The Interplay Between Replacement and Retention of Histones in the Sperm Genome

Frontiers in Genetics, 2020
The genome of eukaryotes is highly organized within the cell nucleus, this organization per se elicits gene regulation and favors other mechanisms like cell memory throughout histones and their post-translational modifications.
Ulises Torres-Flores, Abrahan Hernández-Hernández   +1 more
doaj   +1 more source