Results 251 to 260 of about 2,005,250 (367)

The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation

Advanced Science, EarlyView.
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley   +1 more source

Hypoxia-Driven Histone Modifications Govern Gene Regulation for Mature Eye Lens Formation. [PDF]

Invest Ophthalmol Vis Sci
Brennan L, Disatham J, Kantorow M.
europepmc   +1 more source

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

TET1 loss propels the development of hyperthyroidism by remodeling histone modifications of PAX8 promoter. [PDF]

Exp Mol Med
Dang H, Liu Y, Zhou Y, Sui M, Wang Y, Qiang W, Sui F, Zhang Y, Cao H, Wu X, Ji M, Hou P.   +11 more
europepmc   +1 more source

Histone Modifications: Insights into Their Influence on Gene Expression

Cell, 2018
B. Stillman
semanticscholar   +1 more source

Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques

Advanced Science, EarlyView.
Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang, Ying Hu, Yang Teng, Jiwei Qi, Yangzhen Ciren, Lin Zhang, Qiao Du, Wencai Xu, Liang Zhou, Zhenxin Fan, Jinchuan Xing, Ming Li, Jing Li   +12 more
wiley   +1 more source

Role of vascular smooth muscle phenotypic transformation induced by histone modifications in the development of abdominal aortic aneurysms. [PDF]

Clin Epigenetics
Chen Z, Sun Y, Zhu P, Zhang L, Yang J, Zhang J.   +5 more
europepmc   +1 more source

Development of Endogenous Protein Probes for Characterizing Surface Proteins and Cellular Interactors of Extracellular Vesicles

Advanced Science, EarlyView.
The proximity labeling enzyme APEX2 is displayed on extracellular vesicle (EV) surfaces via genetic fusion with EV‐sorting scaffolds, enabling in situ biotinylation of native surface proteins, adsorbed corona components, and interacting cellular proteins.
Wenyi Zheng, Metoboroghene Mowoe, Wenqing Hou, Daniel W. Hagey, Koshi Imami, Samir EL Andaloussi   +5 more
wiley   +1 more source

Histone modifications in cervical cancer: Epigenetic mechanisms, functions and clinical implications (Review). [PDF]

Oncol Rep
Li X, Zhou M, Yu J, Yu S, Ruan Z.
europepmc   +1 more source

Histone modifications proposed to regulate sexual differentiation of brain and behavior [PDF]

, 2010
Khatuna Gagnidze, Zachary M. Weil, Donald W. Pfaff   +2 more
openalex   +1 more source