Results 271 to 280 of about 1,862,085 (289)

Plasticity of histone modification around Cidea and Cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis

, 2019
Urmi Jeenat Ferdous, Yukiko Kohmura‐Kobayashi, Keiko Muramatsu‐Kato, Natsuyo Hariya, Divyanu Jain, Naoaki Tamura, Toshiyuki Uchida, Kazunao Suzuki, Yoshihiro Ogawa, Nobuaki Shiraki, Kazuki Mochizuki, Takeo Kubota, Naohiro Kanayama, Hiroaki Itoh   +13 more
openalex   +1 more source

CSN6 Promotes Pancreatic Cancer Progression and Gemcitabine Resistance via Antagonizing DCAF1‐Mediated Ubiquitination of NPM1

Advanced Science, EarlyView.
COP9 signalosome subunit 6 (CSN6) promotes the auto‐ubiquitination and degradation of DDB1‐CUL4 associated factor 1 (DCAF1), thereby antagonizing DCAF1‐mediated ubiquitination of Nucleophosmin (NPM1). This stabilization of NPM1 enhances the ribosome biogenesis process and the translation of specific gemcitabine‐resistance proteins, ultimately driving ...
Yijing Zhang, Han Gao, Aiwen Tang, Haiwen Lyu, Zongmin Fan, Jiahui Guo, Yuzhi Wang, Hairong Yi, Qihao Pan, Haidan Luo, Baifu Qin, Boyu Zhang, Xiangqi Meng, Qingxin Liu, Mong‐Hong Lee   +14 more
wiley   +1 more source

EM2, a Natural Product MST1/2 Kinase Activator, Suppresses Non‐Small Cell Lung Cancer via Hippo Pathway Activation

Advanced Science, EarlyView.
EM2 directly binds to and activates MST1/2, enhancing their kinase activity and sequentially promoting LATS phosphorylation, which increases YAP phosphorylation. Consequently, YAP nuclear translocation is suppressed, leading to reduced transcription of downstream targets CTGF and CYR61, ultimately exerting a robust inhibitory effect on NSCLC cell ...
Siyu Yang, Huayan Xie, Qiang Lin, Liujin Zhou, Junxi Liu, Zekai Fang, Ziling Tang, Ruijie Yuan, Jinxuan Su, Sijia Li, Wenlin Wang, Mingyu Pan, Hao Wang, Xiaoyong Dai, Guocai Wang, Yubo Zhang   +15 more
wiley   +1 more source

Multiomics Reveal Associations Between CpG Methylation, Histone Modifications and Transcription in a Species That has Lost DNMT3, the Colorado Potato Beetle. [PDF]

J Exp Zool B Mol Dev Evol
Länger ZM, Israel E, Engelhardt J, Kalita AI, Keller Valsecchi CI, Kurtz J, Prohaska SJ.   +6 more
europepmc   +1 more source

Melatonin Modulates ZAP70 and CD40 Transcripts via Histone Modifications in Canine Ileum Epithelial Cells. [PDF]

Vet Sci
Hong J, Adam SY, Wang S, Huang H, Kim IH, Ahmed AA, Liu HY, Cai D.   +7 more
europepmc   +1 more source

Dynamic atlas of histone modifications and gene regulatory networks in endosperm of bread wheat. [PDF]

Nat Commun
He C, Bi S, Li Y, Song C, Zhang H, Xu X, Li Q, Saeed S, Chen W, Zhao C, Lan C, Su H, Mao H, Yan W.   +13 more
europepmc   +1 more source

Unraveled: The role of Arabidopsis GTE4-EML in transcription via two distinct histone modifications. [PDF]

Plant Cell
Ng PQ.
europepmc   +1 more source

Dynamic Changes in Histone Modifications Are Associated with Differential Chromatin Interactions. [PDF]

Genes (Basel)
Nie Y, Wang M.
europepmc   +1 more source

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Histone modifications and their role in epigenetics of cancer.

Current Medicinal Chemistry, 2021
Epigenetic regulations play a crucial role in the expression of various genes that are important in the normal cell function. Any alteration in these epigenetic mechanisms can lead to the modification of histone and DNA resulting in the silencing or ...
S. Zaib, Neha Rana, Imtiaz Khan
semanticscholar   +1 more source