Results 111 to 120 of about 723,033 (304)

New Histone H4 variant and H2B variant Exhibits distinct genomic distributions, chromatin affinities, and dynamics throughout life and cell cycle of Trypanosoma cruzi.

PLoS Pathogens
Histone variants play crucial roles in chromatin organization and transcriptional regulation in eukaryotes. Unusually, trypanosomatids display histone variants for all histones, although a functional homolog of histone H4 variant (H4.V) had not yet been ...
Juliana Nunes Roson, Mariana Loterio-Silva, Herbert Guimaraes de Sousaes Silva, Thaina Rodrigues de Almeida, Nadjania Saraiva de Lira Silva, Camila Gachet-Castro, Héllida Marina Costa-Silva, Vincent Louis Viala, Sergio Schenkman, M Carolina Elias, Julia P C da Cunha   +10 more
doaj   +1 more source

The quantitative architecture of centromeric chromatin

eLife, 2014
The centromere, responsible for chromosome segregation during mitosis, is epigenetically defined by CENP-A containing chromatin. The amount of centromeric CENP-A has direct implications for both the architecture and epigenetic inheritance of centromeres.
Dani L Bodor, João F Mata, Mikhail Sergeev, Ana Filipa David, Kevan J Salimian, Tanya Panchenko, Don W Cleveland, Ben E Black, Jagesh V Shah, Lars ET Jansen   +9 more
doaj   +1 more source

Histone variant H2A.Z is required for early mammalian development

, 2001
Fundamental to the process of mammalian development is the timed and coordinated regulation of gene expression. This requires transcription of a precise subset of the total complement of genes.
Renate Faast, Matthaei, K., Faast, Renate, Julian R.E Wells, Jacquie Beall, Taylor, H., Matthaei, Klaus, Schulz, T., Varaporn Thonglairoam, Klaus Matthaei, Lyons, I., Beall, Jacquie, Helen Taylor, Lyons, Ian, Tremethick, David, Peter D Rathjen, Tremethick, D., Schulz, Thomas C., Rathjen, P., Rathjen, Peter D., Taylor, Helen, David J Tremethick, Faast, R., Thonglairoam, V., Wells, J., Ian Lyons, Wells, Julian, Thonglairoam, Varaporn, Beall, J., Thomas C Schulz   +29 more
core   +1 more source

Race and Household Income Are Associated With Disease Outcomes in Pediatric Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Hospitalized in the United States

Arthritis Care &Research, EarlyView.
Objective Race and household income impact outcomes in patients with rheumatic conditions; however, their role in pediatric antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) remains poorly understood. We aimed to evaluate whether race and ethnicity and household income are associated with severe AAV disease and renal outcomes among
Roberto Alejandro Valdovinos, William Daniel Soulsby III, Emily von Scheven   +2 more
wiley   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Histone variants in archaea

, 2022
Eukaryotic histone variants are involved in a wide range of processes and play a key role in altering nucleosome dynamics to shape the architecture of chromatin. The importance of individual variants has been studied extensively in many eukaryotes. In comparison, we know relatively little about histones in archaea.
openaire   +2 more sources

Histone variants--the structure behind the function [PDF]

Briefings in Functional Genomics and Proteomics, 2006
In recent years, the chromatin field has witnessed a renewed interest in histone variants as pertaining to their structural role, but mainly because of the functional specificity they impart to chromatin. In this review, I am going to discuss several of the most recent structural studies on core histone (H2A.Bbd, H2A.Z, H2A.X, macroH2A, H3.3, CENP-A ...
openaire   +2 more sources

The histone variant macroH2A1 is a splicing-modulated caretaker of genome integrity and tumor growth

, 2018
The macroH2A1.2 histone variant facilitates the response to replication stress with implications for genome maintenance and cell growth. A mutually exclusive splice variant, macroH2A1.1, has opposing effects on DNA repair outcome and proliferation.
Simran Khurana, Philipp Oberdoerffer, Jeongkyu Kim   +2 more
core   +1 more source

CTCF induces histone variant incorporation, erases the H3K27me3 histone mark and opens chromatin [PDF]

, 2014
Insulators functionally separate active chromatin domains frominactive ones. The insulator factor, CTCF, has been found to bind to boundaries and to mediate insulator function. CTCF binding sites are depleted for the histone modification H3K27me3 and are
Leers, J. (Joerg), Gunther, K, Baierl, M. (Manuel), Schulte, A. (Astrid), Weth, O. (Oliver), Leers, J, Renkawitz, R. (Rainer), Galjart, N.J. (Niels), Baierl, M, Weth, O, Paprotka, C. (Christine), Günther, K. (Katharina), Galjart, Niels; id_orcid, Paprotka, C, Schulte, A, Renkawitz, R   +15 more
core   +1 more source

Artemisinin‐Loaded Core‐Shell Microspheres Modulate Histone Lactylation to Remodel the Microenvironment for Cartilage Protection in Rheumatoid Arthritis

Advanced Healthcare Materials, EarlyView.
ART@PLGA@GH‐A microspheres are developed via microfluidic technology for intra‐articular delivery of artemisinin. The system remodels rheumatoid arthritis microenvironments by regulating metabolic and inflammatory disorders, reducing lactate‐driven histone lactylation and cellular senescence, while restoring cartilage homeostasis and protecting joint ...
Shijie Meng, Jianxin Li, Yuyang Luo, Yisi Liu, Feng Xing, Yingchen Ni, Fengyuan Zhang, Zhicheng Fan, Hua Xu, Weidong Zhang, Youhua Wang   +10 more
wiley   +1 more source