Results 91 to 100 of about 723,033 (304)

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Spermatid-specific linker histone HILS1 is a poor condenser of DNA and chromatin and preferentially associates with LINE-1 elements

Epigenetics & Chromatin, 2018
Background Linker histones establish and maintain higher-order chromatin structure. Eleven linker histone subtypes have been reported in mammals. HILS1 is a spermatid-specific linker histone, and its expression overlaps with the histone–protamine ...
Laxmi Narayan Mishra, Vasantha Shalini, Nikhil Gupta, Krittika Ghosh, Neeraj Suthar, Utsa Bhaduri, M. R. Satyanarayana Rao   +6 more
doaj   +1 more source

Histone variants and histone exchange

, 2006
Histories, as basic components of nucleosome. are essential to chromatin structure and function. To adapt to various states of chromatin, corresponding histone variants are incorporated in nucleosome, and certain modifications also occur on the variants ...
Gui Jian-Fang (jfgui@ihb.ac.cn), Wu Nan (wunan@ihb.ac.cn), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol and Biotechnol, Wuhan 430072, Peoples R China, Wu Nan   +3 more
core  

Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation. [PDF]

, 2010
Methylation of residues in histone tails is part of a network that regulates gene expression. JmjC domain containing proteins catalyze the oxidative removal of methyl groups on histone lysine residues.
Böttger, Angelika, Burrells Alison, Andreas Lengeling, Butler, Danica, Hahn, P., Erck, Christian, Wolf, A., Lengeling, A., Bottger, A., Jens Böse, Erck, C., Christopher J Schofield, Wegener, Ivonne, Wegener Ivonne, Böse, Jens, Christian Erck, Angelika Böttger, Ivonne Wegener, Butler Danica, Lengeling Andreas, Böse Jens, Burrells, A., Alexander Wolf, Hahn Phillip, Bose, J., Erck Christian, Böttger Angelika, Danica Butler, Phillip Hahn, Butler, D., Wolf Alexander, Hahn, Phillip, Wolf, Alexander, Schofield, Christopher J, Alison Burrells, Schofield Christopher J., Lengeling, Andreas, Schofield, Christopher J., Wegener, I., Burrells, Alison, Christopher J. Schofield   +40 more
core   +2 more sources

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Linker histone variant H1t is closely associated with repressed repeat-element chromatin domains in pachytene spermatocytes

Epigenetics & Chromatin, 2020
Background H1t is the major linker histone variant in pachytene spermatocytes, where it constitutes 50–60% of total H1. This linker histone variant was previously reported to localize in the nucleolar rDNA element in mouse spermatocytes. Our main aim was
Iyer Aditya Mahadevan, Sanjeev Kumar, Manchanahalli R. Satyanarayana Rao   +2 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Function of HP1BP3 as a linker histone is regulated by linker histone chaperones, NPM1 and TAF-I

Epigenetics & Chromatin
Background Linker histones constitute a class of proteins that are responsible for the formation of higher-order chromatin structures. Core histones are integral components of nucleosome core particles (NCPs), whereas linker histones bind to linker DNA ...
Miharu Hisaoka, Tetsuro Komatsu, Takuma Hashimoto, Jianhuang Lin, Yasuyuki Ohkawa, Mitsuru Okuwaki   +5 more
doaj   +1 more source

Distinct Features of the Histone Core Structure in Nucleosomes Containing the Histone H2A.B Variant

, 2014
Nucleosomes containing a human histone variant, H2A.B, in an aqueous solution were analyzed by small-angle neutron scattering utilizing a contrast variation technique.
Sato, Nobuhiro, Arimura, Yasuhiro, Oba, Yojiro, Fujita, Risa, Shirayama, Kazuyoshi, Sugiyama, Masaaki, Oda, Takashi, Heenan, Richard K., Sato, Mamoru, Inoue, Rintaro, Kurumizaka, Hitoshi   +10 more
core   +1 more source