Results 71 to 80 of about 723,033 (304)

The Histone Variant H3.3 Is Enriched at Drosophila Amplicon Origins but Does Not Mark Them for Activation

G3: Genes, Genomes, Genetics, 2016
Eukaryotic DNA replication begins from multiple origins. The origin recognition complex (ORC) binds origin DNA and scaffolds assembly of a prereplicative complex (pre-RC), which is subsequently activated to initiate DNA replication.
Neha P. Paranjape, Brian R. Calvi
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Histone Variants and Their Chaperones: An Emerging Epigenetic Mechanism in Neurodevelopment and Neurodevelopmental Disorders

Journal of Integrative Neuroscience, 2023
Neurodevelopment is a highly regulated process that relies on the precise regulation of gene expression. Numerous epigenetic mechanisms contribute and cooperate to ensure the proper execution of developmental gene expression programs.
Karanveer S Johal, Manjinder S Cheema, Gilda Stefanelli   +2 more
doaj   +1 more source

Schematic view of histone variant enrichment in various genome regions.

, 2014
Relative enrichment of each histone variant in various genome regions is indicated by the ellipse magnitude. Stability (+) and (−) indicate stable and unstable chromatin, respectively. Chromatin was unstable only in regions enriched for both H2A.Z and H3.
Yutaka Suzuki (1379), Kuniya Abe (64132), Hiroyuki Aburatani (162634), Tomohiko Akiyama (202078), Kristian Vlahovicek (5658394), Masashi Yukawa (10097), Masataka G. Suzuki (12939), Fugaku Aoki (202084), Vedran Franke (523109), Nathan Mise (265452), Takayuki Isagawa (201875)   +10 more
core   +1 more source

Selective methylation of histone H3 variant H3.1 regulates heterochromatin replication [PDF]

, 2014
Histone variants have been proposed to act as determinants for posttranslational modifications with widespread regulatory functions. We identify a histone-modifying enzyme that selectively methylates the replication-dependent histone H3 variant H3.1. The
Voigt, Philipp, Bergamin, E., Brunzelle, Joseph S., Bergamin, Elisa, Jacob, Y., Bergamin, E., LeBlanc, C., Voigt, P., Michaels, S. D., Underwood, Charles J, Donoghue, M. T., Martienssen, Robert, Michaels, Scott D., Underwood, Charles, Jacob, Yannick, Underwood, C. J., Michaels, Scott, Reinberg, D., Reinberg, Danny, Martienssen, R. A., Couture, Jean-François, Couture, J. F., Brunzelle, J. S., Mongeon, V., Mongeon, Vanessa, Brunzelle, Joseph, Donoghue, Mark, Donoghue, Mark T.A., LeBlanc, Chantal, Martienssen, Robert A.   +29 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Native and tagged CENP-A histones are functionally inequivalent

Epigenetics & Chromatin
Background Over the past several decades, the use of biochemical and fluorescent tags has elucidated mechanistic and cytological processes that would otherwise be impossible. The challenging nature of certain nuclear proteins includes low abundancy, poor
Minh Bui, Songjoon Baek, Reda S. Bentahar, Daniël P. Melters, Yamini Dalal   +4 more
doaj   +1 more source

Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis

Cell Reports, 2017
Cellular differentiation is associated with dynamic chromatin remodeling in establishing a cell-type-specific epigenomic landscape. Here, we find that mouse testis-specific and replication-dependent histone H3 variant H3t is essential for very early ...
Jun Ueda, Akihito Harada, Takashi Urahama, Shinichi Machida, Kazumitsu Maehara, Masashi Hada, Yoshinori Makino, Jumpei Nogami, Naoki Horikoshi, Akihisa Osakabe, Hiroyuki Taguchi, Hiroki Tanaka, Hiroaki Tachiwana, Tatsuma Yao, Minami Yamada, Takashi Iwamoto, Ayako Isotani, Masahito Ikawa, Taro Tachibana, Yuki Okada, Hiroshi Kimura, Yasuyuki Ohkawa, Hitoshi Kurumizaka, Kazuo Yamagata   +23 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Characterization of a novel chromatin sorting tool reveals importance of histone variant H3.3 in contextual fear memory and motor learning

Frontiers in Molecular Neuroscience, 2016
The consolidation of short-term labile memories for long-term storage requires transcription and there is growing interest in defining the epigenetic mechanisms regulating these transcriptional events.
Anna G McNally, Shane G Poplawski, Brittany A Mayweather, Kyle M White, Ted eAbel   +4 more
doaj   +1 more source